L2L L2L Microarray Analysis Tool

Results for L01C.profile.ud50

Results summary View all lists in L2L MDB View all genes in L01C.profile.ud50
List Name Description Total
probes
Expected
matches
Actual
matches
Fold
Enrichment
Binomial
p-value
lvad_heartfailure_up Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device 180 0.89 7 7.87 3.70e-05
camptothecin_probcell_dn Down-regulated in pro-B cells (FL5.12) following treatment with camptothecin 52 0.26 4 15.56 1.34e-04
shortattacklatency_up Up-regulated in hippocampi from a mouse line selected for long attack latency (LAL) against an intruder, versus a line selected for short attack latency (SAL). 156 0.77 6 7.78 1.41e-04
nf90_up Upregulated by ectopic expression of NF90 in GHOST(3)CXCR4 cells 56 0.28 4 14.45 1.79e-04
heatshock_hela_2hr_up Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 177 0.88 6 6.86 2.79e-04
senescence_hela_up Up-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. 262 1.30 7 5.40 3.74e-04
uvc_high_all_dn Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9) 634 3.13 11 3.51 4.01e-04
uvc_high_d1_dn Down-regulated at 6 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d1) 31 0.15 3 19.57 4.90e-04
bcnu_glioma_mgmt_48hrs_up Up-regulated in an MGMT+ glioma cell line (T98G) at 48 hours following treatment with BCNU 33 0.16 3 18.39 5.90e-04
senescence_hff_up Up-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). 284 1.40 7 4.99 6.04e-04
cox1_ko_cortex_up Up-regulated in the cerebral cortex of COX1-/- mice compared to wild-type controls. 80 0.40 4 10.11 7.00e-04
alk1_hmvec_2hr_up Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 593 2.93 10 3.41 8.95e-04
alk1_hmvec_4hr_up Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 593 2.93 10 3.41 8.95e-04
creb_brain_2wks_up Up-regulated in the nucleus accumbens of mice after 2 weeks of induction of transgenic CREB 39 0.19 3 15.56 9.67e-04
uvc_high_d3_dn Progressively down-regulated through 12 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d3) 90 0.44 4 8.99 1.09e-03
il6_scar_fibro_up Upregulated following IL-6 treatment in hypertrophic scar fibroblasts 44 0.22 3 13.79 1.38e-03
uvb_nhek1_up Upregulated by UV-B light in normal human epidermal keratinocytes 336 1.66 7 4.21 1.59e-03
vhl_normal_up Upregulated in VHL-null renal carcinoma vs. normal renal cells (Fig. 2c+e) 754 3.73 11 2.95 1.61e-03
ageing_brain_up Age-upregulated in the human frontal cortex 446 2.20 8 3.63 1.94e-03
hippocampus_development_neonatal Highly expressed in neonatal mouse hippocampus (clusters 4 and 8) 51 0.25 3 11.90 2.11e-03
adipogenesis_hmsc_class3_up Up-regulated 3-14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class III) 109 0.54 4 7.42 2.20e-03
hematop_stem_all_up Up-regulated in populations of human hematopoietic stem cells (CD34+/CD38-/Lin-) from bone marrow, umbilical cord blood, and peripheral blood stem-progenitor cells, compared to the stem cell-depleted population (CD34+/[CD38/Lin++]) 52 0.26 3 11.67 2.23e-03
heatshock_hela_4hr_up Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 675 3.34 10 3.00 2.31e-03
adipogenesis_hmsc_class5_up Up-regulated 9 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class V) 16 0.08 2 25.28 2.80e-03
tsadac_hypermeth_hyperac_ovca_up Genes with basally hypermethylated promoters upregulated by the combination of TSA and DAC in ovarian carcinoma (CP70) cells, with hyperacetylated promoters upon activation 16 0.08 2 25.28 2.80e-03
serum_fibroblast_cellcycle Cell-cycle dependent genes regulated following exposure to serum in a variety of human fibroblast cell lines 197 0.97 5 5.13 3.17e-03
reovirus_hek293_up Up-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney 491 2.43 8 3.30 3.47e-03
tsadac_hypermeth_ovca_up Genes with basally hypermethylated promoters upregulated by the combination of TSA and DAC in ovarian carcinoma (CP70) cells 18 0.09 2 22.47 3.55e-03
adip_diff_cluster2 Strongly upregulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 2) 64 0.32 3 9.48 4.02e-03
adip_vs_fibro_dn Downregulated following 7-day differentiation of murine 3T3-L1 fibroblasts into adipocytes 64 0.32 3 9.48 4.02e-03
ni2_mouse_up Upregulated by nickel(II) in sensitive A/J mouse lung tissue 65 0.32 3 9.34 4.20e-03
uvb_nhek1_c4 Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 4 20 0.10 2 20.23 4.38e-03
uvb_nhek3_all Regulated by UV-B light in normal human epidermal keratinocytes 751 3.71 10 2.69 4.85e-03
dex_keratinocyte_1hr_dn Down-regulated in primary human keratinocytes at 1 hour following treatment with 0.1 microM dexamethasone 24 0.12 2 16.86 6.28e-03
heat_glioblastoma_up Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). 78 0.39 3 7.78 6.98e-03
dac_cgi_bladder_up Upregulated by DAC treatment in T24 bladder carcinoma cells, with 5' CpG island 26 0.13 2 15.56 7.34e-03
h2o2_csbcombined Upregulated by H2O2 in CSB-rescued fibroblasts, but deficient induction in CSB-null (Table 3) 26 0.13 2 15.56 7.34e-03
ad12_32hrs_dn Down-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at 32 hours post-infection 27 0.13 2 14.98 7.90e-03
pdgf_es_up Up-regulated by PDGF in mouse embryonic stem cells, via microarray-coupled gene-trap mutagenesis 28 0.14 2 14.45 8.48e-03
uvb_nhek1_c2 Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 2 28 0.14 2 14.45 8.48e-03
uvb_nhek2_dn Downregulated by UV-B light in normal human epidermal keratinocytes 160 0.79 4 5.06 8.54e-03
adip_vs_preadip_dn Downregulated in mature murine adipocytes (7 day differentiation) vs. preadipocytes (6 hr differentiation) 84 0.42 3 7.22 8.55e-03
h2o2_csbrescued_c1_up Upregulated by H2O2 in CSB-rescued fibroblasts (Table 1, cluster 1) 84 0.42 3 7.22 8.55e-03
il6_fibro_up Upregulated following IL-6 treatment in normal skin fibroblasts 85 0.42 3 7.14 8.83e-03
vegf_hmmec_6hrs_up Up-regulated at 6hrs follwing VEGF treatment of human myometrial microvascular endothelial cells 88 0.44 3 6.90 9.70e-03

Raw data (tab-delimited .txt)