Results summary | View all lists in L2L MDB | View all genes in L01C.profile.ud50 |
List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
---|---|---|---|---|---|---|
lvad_heartfailure_up | Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device | 180 | 0.89 | 7 | 7.87 | 3.70e-05 |
camptothecin_probcell_dn | Down-regulated in pro-B cells (FL5.12) following treatment with camptothecin | 52 | 0.26 | 4 | 15.56 | 1.34e-04 |
shortattacklatency_up | Up-regulated in hippocampi from a mouse line selected for long attack latency (LAL) against an intruder, versus a line selected for short attack latency (SAL). | 156 | 0.77 | 6 | 7.78 | 1.41e-04 |
nf90_up | Upregulated by ectopic expression of NF90 in GHOST(3)CXCR4 cells | 56 | 0.28 | 4 | 14.45 | 1.79e-04 |
heatshock_hela_2hr_up | Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 177 | 0.88 | 6 | 6.86 | 2.79e-04 |
senescence_hela_up | Up-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. | 262 | 1.30 | 7 | 5.40 | 3.74e-04 |
uvc_high_all_dn | Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9) | 634 | 3.13 | 11 | 3.51 | 4.01e-04 |
uvc_high_d1_dn | Down-regulated at 6 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d1) | 31 | 0.15 | 3 | 19.57 | 4.90e-04 |
bcnu_glioma_mgmt_48hrs_up | Up-regulated in an MGMT+ glioma cell line (T98G) at 48 hours following treatment with BCNU | 33 | 0.16 | 3 | 18.39 | 5.90e-04 |
senescence_hff_up | Up-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). | 284 | 1.40 | 7 | 4.99 | 6.04e-04 |
cox1_ko_cortex_up | Up-regulated in the cerebral cortex of COX1-/- mice compared to wild-type controls. | 80 | 0.40 | 4 | 10.11 | 7.00e-04 |
alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 2.93 | 10 | 3.41 | 8.95e-04 |
alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 2.93 | 10 | 3.41 | 8.95e-04 |
creb_brain_2wks_up | Up-regulated in the nucleus accumbens of mice after 2 weeks of induction of transgenic CREB | 39 | 0.19 | 3 | 15.56 | 9.67e-04 |
uvc_high_d3_dn | Progressively down-regulated through 12 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d3) | 90 | 0.44 | 4 | 8.99 | 1.09e-03 |
il6_scar_fibro_up | Upregulated following IL-6 treatment in hypertrophic scar fibroblasts | 44 | 0.22 | 3 | 13.79 | 1.38e-03 |
uvb_nhek1_up | Upregulated by UV-B light in normal human epidermal keratinocytes | 336 | 1.66 | 7 | 4.21 | 1.59e-03 |
vhl_normal_up | Upregulated in VHL-null renal carcinoma vs. normal renal cells (Fig. 2c+e) | 754 | 3.73 | 11 | 2.95 | 1.61e-03 |
ageing_brain_up | Age-upregulated in the human frontal cortex | 446 | 2.20 | 8 | 3.63 | 1.94e-03 |
hippocampus_development_neonatal | Highly expressed in neonatal mouse hippocampus (clusters 4 and 8) | 51 | 0.25 | 3 | 11.90 | 2.11e-03 |
adipogenesis_hmsc_class3_up | Up-regulated 3-14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class III) | 109 | 0.54 | 4 | 7.42 | 2.20e-03 |
hematop_stem_all_up | Up-regulated in populations of human hematopoietic stem cells (CD34+/CD38-/Lin-) from bone marrow, umbilical cord blood, and peripheral blood stem-progenitor cells, compared to the stem cell-depleted population (CD34+/[CD38/Lin++]) | 52 | 0.26 | 3 | 11.67 | 2.23e-03 |
heatshock_hela_4hr_up | Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 675 | 3.34 | 10 | 3.00 | 2.31e-03 |
adipogenesis_hmsc_class5_up | Up-regulated 9 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class V) | 16 | 0.08 | 2 | 25.28 | 2.80e-03 |
tsadac_hypermeth_hyperac_ovca_up | Genes with basally hypermethylated promoters upregulated by the combination of TSA and DAC in ovarian carcinoma (CP70) cells, with hyperacetylated promoters upon activation | 16 | 0.08 | 2 | 25.28 | 2.80e-03 |
serum_fibroblast_cellcycle | Cell-cycle dependent genes regulated following exposure to serum in a variety of human fibroblast cell lines | 197 | 0.97 | 5 | 5.13 | 3.17e-03 |
reovirus_hek293_up | Up-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney | 491 | 2.43 | 8 | 3.30 | 3.47e-03 |
tsadac_hypermeth_ovca_up | Genes with basally hypermethylated promoters upregulated by the combination of TSA and DAC in ovarian carcinoma (CP70) cells | 18 | 0.09 | 2 | 22.47 | 3.55e-03 |
adip_diff_cluster2 | Strongly upregulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 2) | 64 | 0.32 | 3 | 9.48 | 4.02e-03 |
adip_vs_fibro_dn | Downregulated following 7-day differentiation of murine 3T3-L1 fibroblasts into adipocytes | 64 | 0.32 | 3 | 9.48 | 4.02e-03 |
ni2_mouse_up | Upregulated by nickel(II) in sensitive A/J mouse lung tissue | 65 | 0.32 | 3 | 9.34 | 4.20e-03 |
uvb_nhek1_c4 | Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 4 | 20 | 0.10 | 2 | 20.23 | 4.38e-03 |
uvb_nhek3_all | Regulated by UV-B light in normal human epidermal keratinocytes | 751 | 3.71 | 10 | 2.69 | 4.85e-03 |
dex_keratinocyte_1hr_dn | Down-regulated in primary human keratinocytes at 1 hour following treatment with 0.1 microM dexamethasone | 24 | 0.12 | 2 | 16.86 | 6.28e-03 |
heat_glioblastoma_up | Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). | 78 | 0.39 | 3 | 7.78 | 6.98e-03 |
dac_cgi_bladder_up | Upregulated by DAC treatment in T24 bladder carcinoma cells, with 5' CpG island | 26 | 0.13 | 2 | 15.56 | 7.34e-03 |
h2o2_csbcombined | Upregulated by H2O2 in CSB-rescued fibroblasts, but deficient induction in CSB-null (Table 3) | 26 | 0.13 | 2 | 15.56 | 7.34e-03 |
ad12_32hrs_dn | Down-regulated 2-fold in HeLa cells by Adenovirus type 12 (Ad12) at 32 hours post-infection | 27 | 0.13 | 2 | 14.98 | 7.90e-03 |
pdgf_es_up | Up-regulated by PDGF in mouse embryonic stem cells, via microarray-coupled gene-trap mutagenesis | 28 | 0.14 | 2 | 14.45 | 8.48e-03 |
uvb_nhek1_c2 | Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 2 | 28 | 0.14 | 2 | 14.45 | 8.48e-03 |
uvb_nhek2_dn | Downregulated by UV-B light in normal human epidermal keratinocytes | 160 | 0.79 | 4 | 5.06 | 8.54e-03 |
adip_vs_preadip_dn | Downregulated in mature murine adipocytes (7 day differentiation) vs. preadipocytes (6 hr differentiation) | 84 | 0.42 | 3 | 7.22 | 8.55e-03 |
h2o2_csbrescued_c1_up | Upregulated by H2O2 in CSB-rescued fibroblasts (Table 1, cluster 1) | 84 | 0.42 | 3 | 7.22 | 8.55e-03 |
il6_fibro_up | Upregulated following IL-6 treatment in normal skin fibroblasts | 85 | 0.42 | 3 | 7.14 | 8.83e-03 |
vegf_hmmec_6hrs_up | Up-regulated at 6hrs follwing VEGF treatment of human myometrial microvascular endothelial cells | 88 | 0.44 | 3 | 6.90 | 9.70e-03 |