L2L Microarray Analysis Tool
Results for L01C.profile.d50
| Results summary | View all lists in L2L MDB | View all genes in L01C.profile.d50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| camptothecin_probcell_dn | Down-regulated in pro-B cells (FL5.12) following treatment with camptothecin | 52 | 0.13 | 4 | 31.12 | 9.19e-06 |
| nf90_up | Upregulated by ectopic expression of NF90 in GHOST(3)CXCR4 cells | 56 | 0.14 | 4 | 28.90 | 1.24e-05 |
| bcnu_glioma_mgmt_48hrs_up | Up-regulated in an MGMT+ glioma cell line (T98G) at 48 hours following treatment with BCNU | 33 | 0.08 | 3 | 36.78 | 7.80e-05 |
| creb_brain_2wks_up | Up-regulated in the nucleus accumbens of mice after 2 weeks of induction of transgenic CREB | 39 | 0.10 | 3 | 31.12 | 1.29e-04 |
| vhl_normal_up | Upregulated in VHL-null renal carcinoma vs. normal renal cells (Fig. 2c+e) | 754 | 1.86 | 9 | 4.83 | 1.38e-04 |
| serum_fibroblast_cellcycle | Cell-cycle dependent genes regulated following exposure to serum in a variety of human fibroblast cell lines | 197 | 0.49 | 5 | 10.27 | 1.46e-04 |
| hippocampus_development_neonatal | Highly expressed in neonatal mouse hippocampus (clusters 4 and 8) | 51 | 0.13 | 3 | 23.80 | 2.88e-04 |
| adip_vs_fibro_dn | Downregulated following 7-day differentiation of murine 3T3-L1 fibroblasts into adipocytes | 64 | 0.16 | 3 | 18.96 | 5.62e-04 |
| shortattacklatency_up | Up-regulated in hippocampi from a mouse line selected for long attack latency (LAL) against an intruder, versus a line selected for short attack latency (SAL). | 156 | 0.39 | 4 | 10.37 | 6.57e-04 |
| adipogenesis_hmsc_class5_up | Up-regulated 9 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class V) | 16 | 0.04 | 2 | 50.57 | 7.17e-04 |
| cox1_ko_cortex_up | Up-regulated in the cerebral cortex of COX1-/- mice compared to wild-type controls. | 80 | 0.20 | 3 | 15.17 | 1.08e-03 |
| adip_vs_preadip_dn | Downregulated in mature murine adipocytes (7 day differentiation) vs. preadipocytes (6 hr differentiation) | 84 | 0.21 | 3 | 14.45 | 1.24e-03 |
| rb_creko_up | Up-regulated at 144 hours after disruption of Rb in adult mouse fibroblasts by Cre recombination, versus GFP controls. | 344 | 0.85 | 5 | 5.88 | 1.80e-03 |
| h2o2_csbcombined | Upregulated by H2O2 in CSB-rescued fibroblasts, but deficient induction in CSB-null (Table 3) | 26 | 0.06 | 2 | 31.12 | 1.91e-03 |
| cancer_undifferentiated_meta_up | Sixty-nine genes commonly upregulated in undifferentiated cancer relative to well-differentiated cancer, from a meta-analysis of the OncoMine gene expression database | 98 | 0.24 | 3 | 12.38 | 1.93e-03 |
| rcc_nl_up | Upregulated in VHL-rescued renal carcinoma vs. normal renal cells (Fig. 2d+e) | 899 | 2.22 | 8 | 3.60 | 2.07e-03 |
| o6bg_resist_medulloblastoma_dn | Up-regulated in a medulloblastoma cell line resistant to both BCNU and O6-BG, compared to sensitive parent line (D-341 MED) | 109 | 0.27 | 3 | 11.13 | 2.61e-03 |
| aged_mouse_neocortex_up | Upregulated in the neocortex of aged adult mice (30-month) vs. young adult (5-month) | 111 | 0.27 | 3 | 10.93 | 2.75e-03 |
| cancer_neoplastic_meta_up | Sixty-seven genes commonly upregulated in cancer relative to normal tissue, from a meta-analysis of the OncoMine gene expression database | 115 | 0.28 | 3 | 10.55 | 3.03e-03 |
| heartfailure_ventricles_dn | Downregulated in the ventricles of failing hearts (DCM and ICM) compared to healthy controls | 120 | 0.30 | 3 | 10.11 | 3.42e-03 |
| senescence_hela_up | Up-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. | 262 | 0.65 | 4 | 6.18 | 4.32e-03 |
| ageing_brain_up | Age-upregulated in the human frontal cortex | 446 | 1.10 | 5 | 4.54 | 5.41e-03 |
| hematop_stem_all_up | Up-regulated in populations of human hematopoietic stem cells (CD34+/CD38-/Lin-) from bone marrow, umbilical cord blood, and peripheral blood stem-progenitor cells, compared to the stem cell-depleted population (CD34+/[CD38/Lin++]) | 52 | 0.13 | 2 | 15.56 | 7.46e-03 |
| pod1_ko_up | Up-regulated in glomeruli isolated from Pod1 knockout mice, versus wild-type controls | 508 | 1.26 | 5 | 3.98 | 9.19e-03 |