L2L Microarray Analysis Tool
Results for L01B.profile.ud50
| Results summary | View all lists in L2L MDB | View all genes in L01B.profile.ud50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| serum_fibroblast_cellcycle | Cell-cycle dependent genes regulated following exposure to serum in a variety of human fibroblast cell lines | 197 | 0.97 | 11 | 11.29 | 6.07e-09 |
| idx_tsa_up_cluster3 | Strongly up-regulated at 16-24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 3) | 136 | 0.67 | 8 | 11.90 | 4.79e-07 |
| dox_resist_gastric_up | Upregulated in gastric cancer cell lines reistant to doxorubicin, compared to parent chemosensitive lines | 74 | 0.37 | 6 | 16.40 | 2.03e-06 |
| p21_p53_early_dn | Down-regulated at early timepoints (4-8 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent | 23 | 0.11 | 4 | 35.18 | 4.91e-06 |
| alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 2.93 | 13 | 4.43 | 1.18e-05 |
| alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 2.93 | 13 | 4.43 | 1.18e-05 |
| adip_diff_cluster5 | Strongly upregulated at 24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 5) | 67 | 0.33 | 5 | 15.09 | 2.21e-05 |
| p21_p53_any_dn | Down-regulated at any timepoint (4-24 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent | 77 | 0.38 | 5 | 13.13 | 4.34e-05 |
| uvb_nhek1_dn | Downregulated by UV-B light in normal human epidermal keratinocytes | 542 | 2.68 | 11 | 4.11 | 1.06e-04 |
| heatshock_hela_2hr_dn | Down-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 223 | 1.10 | 7 | 6.35 | 1.41e-04 |
| senescence_hff_dn | Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). | 299 | 1.48 | 8 | 5.41 | 1.44e-04 |
| middleage_dn | Downregulated in fibroblasts from middle-age individuals, compared to young | 23 | 0.11 | 3 | 26.38 | 1.99e-04 |
| senescence_rep-ind_dn | Down-regulated in models of both replicative (high-passge human foreskin fibroblast) and induced (repression of E7 in HeLa) cellular senescence. | 171 | 0.85 | 6 | 7.10 | 2.32e-04 |
| uvc_xpcs_all_up | Up-regulated at any timepoint following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC | 112 | 0.55 | 5 | 9.03 | 2.55e-04 |
| senescence_hela_dn | Down-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. | 341 | 1.69 | 8 | 4.75 | 3.49e-04 |
| rb_creko_up | Up-regulated at 144 hours after disruption of Rb in adult mouse fibroblasts by Cre recombination, versus GFP controls. | 344 | 1.70 | 8 | 4.70 | 3.70e-04 |
| heatshock_hela_4hr_dn | Down-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 1829 | 9.04 | 20 | 2.21 | 1.08e-03 |
| uvc_xpcs_8hr_up | Up-regulated at 8 hours following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC | 108 | 0.53 | 4 | 7.49 | 2.13e-03 |
| p53genes_apoptosis | p53 transcriptional targets involved in apoptosis | 14 | 0.07 | 2 | 28.90 | 2.14e-03 |
| uvb_nhek1_c6 | Downregulated by UV-B light in normal human epidermal keratinocytes, cluster 6 | 268 | 1.32 | 6 | 4.53 | 2.37e-03 |
| p21_early_dn | Down-regulated at early timepoints (4-8 hrs) follwing ectopic expression of p21 (CDKN1A) in OvCa cells | 16 | 0.08 | 2 | 25.28 | 2.80e-03 |
| tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 6.53 | 15 | 2.30 | 3.01e-03 |
| hippocampus_development_prenatal | Highly expressed in prenatal mouse hippocampus (cluster 1) | 58 | 0.29 | 3 | 10.46 | 3.04e-03 |
| hsc_hscandprogenitors_fetal | Up-regulated in mouse hematopoietic stem cells and progenitors from fetal liver (HSC and Progenitors Shared) | 717 | 3.54 | 10 | 2.82 | 3.52e-03 |
| hsc_hscandprogenitors_shared | Up-regulated in mouse hematopoietic stem cells and progenitors from both adult bone marrow and fetal liver (Cluster iii, HSC and Progenitors Shared) | 717 | 3.54 | 10 | 2.82 | 3.52e-03 |
| hsc_hscandprogenitors_adult | Up-regulated in mouse hematopoietic stem cells and progenitors from adult bone marrow (HSC and Progenitors Shared + Adult) | 724 | 3.58 | 10 | 2.79 | 3.77e-03 |
| uvc_ttd_all_up | Up-regulated at any timepoint following treatment of XPB/TTD fibroblasts with 3 J/m^2 UVC | 140 | 0.69 | 4 | 5.78 | 5.38e-03 |
| cmv_hcmv_timecourse_10hrs_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 10 hours | 23 | 0.11 | 2 | 17.59 | 5.77e-03 |
| oldage_dn | Downregulated in fibroblasts from old individuals, compared to young | 76 | 0.38 | 3 | 7.98 | 6.49e-03 |
| werner_fibro_up | Upregulated in fibroblasts from individuals with Werner syndrome, compared to normal, young individuals | 81 | 0.40 | 3 | 7.49 | 7.74e-03 |
| cmv_hcmv_timecourse_14hrs_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 14 hours | 84 | 0.42 | 3 | 7.22 | 8.55e-03 |
| old_fibro_up | Upregulated in fibroblasts from old individuals, compared to young | 84 | 0.42 | 3 | 7.22 | 8.55e-03 |
| insulin_adip_sens_dn | Down-regulated by insulin in murine adipocytes, but response is blunted following induction of insulin-resistance with TNFalpha treatment | 29 | 0.14 | 2 | 13.95 | 9.08e-03 |
| brca_prognosis_neg | Genes whose expression is consistently negatively correlated with breast cancer outcomes - higher expression is associated with metastasis and poor prognosis | 166 | 0.82 | 4 | 4.87 | 9.68e-03 |
| oldwerner_fibro_up | Commonly upregulated in fibroblasts from Werner Syndrome and old individuals, compared to young | 30 | 0.15 | 2 | 13.48 | 9.70e-03 |
| uvb_nhek3_c0 | Regulated by UV-B light in normal human epidermal keratinocytes, cluster 0 | 167 | 0.83 | 4 | 4.84 | 9.88e-03 |