L2L Microarray Analysis Tool
Results for L01B.profile.d50
| Results summary | View all lists in L2L MDB | View all genes in L01B.profile.d50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| serum_fibroblast_cellcycle | Cell-cycle dependent genes regulated following exposure to serum in a variety of human fibroblast cell lines | 197 | 0.49 | 11 | 22.59 | 4.52e-12 |
| idx_tsa_up_cluster3 | Strongly up-regulated at 16-24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 3) | 136 | 0.34 | 8 | 23.80 | 2.48e-09 |
| dox_resist_gastric_up | Upregulated in gastric cancer cell lines reistant to doxorubicin, compared to parent chemosensitive lines | 74 | 0.18 | 6 | 32.80 | 3.66e-08 |
| p21_p53_early_dn | Down-regulated at early timepoints (4-8 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent | 23 | 0.06 | 4 | 70.35 | 3.18e-07 |
| adip_diff_cluster5 | Strongly upregulated at 24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 5) | 67 | 0.17 | 5 | 30.19 | 7.85e-07 |
| p21_p53_any_dn | Down-regulated at any timepoint (4-24 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent | 77 | 0.19 | 5 | 26.27 | 1.57e-06 |
| senescence_hela_dn | Down-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. | 341 | 0.84 | 8 | 9.49 | 2.81e-06 |
| senescence_rep-ind_dn | Down-regulated in models of both replicative (high-passge human foreskin fibroblast) and induced (repression of E7 in HeLa) cellular senescence. | 171 | 0.42 | 6 | 14.19 | 5.12e-06 |
| uvb_nhek1_dn | Downregulated by UV-B light in normal human epidermal keratinocytes | 542 | 1.34 | 9 | 6.72 | 1.10e-05 |
| senescence_hff_dn | Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). | 299 | 0.74 | 7 | 9.47 | 1.19e-05 |
| heatshock_hela_4hr_dn | Down-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 1829 | 4.52 | 16 | 3.54 | 2.07e-05 |
| middleage_dn | Downregulated in fibroblasts from middle-age individuals, compared to young | 23 | 0.06 | 3 | 52.77 | 2.58e-05 |
| stemcell_embryonic_up | Enriched in mouse embryonic stem cells, compared to differentiated brain and bone marrow cells | 1989 | 4.92 | 15 | 3.05 | 1.85e-04 |
| rb_creko_up | Up-regulated at 144 hours after disruption of Rb in adult mouse fibroblasts by Cre recombination, versus GFP controls. | 344 | 0.85 | 6 | 7.06 | 2.47e-04 |
| heatshock_hela_2hr_dn | Down-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 223 | 0.55 | 5 | 9.07 | 2.59e-04 |
| p21_early_dn | Down-regulated at early timepoints (4-8 hrs) follwing ectopic expression of p21 (CDKN1A) in OvCa cells | 16 | 0.04 | 2 | 50.57 | 7.17e-04 |
| alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 7 | 4.78 | 7.94e-04 |
| alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 7 | 4.78 | 7.94e-04 |
| stemcell_neural_up | Enriched in mouse neural stem cells, compared to differentiated brain and bone marrow cells | 2805 | 6.93 | 17 | 2.45 | 8.51e-04 |
| oldage_dn | Downregulated in fibroblasts from old individuals, compared to young | 76 | 0.19 | 3 | 15.97 | 9.28e-04 |
| cmv_hcmv_timecourse_10hrs_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 10 hours | 23 | 0.06 | 2 | 35.18 | 1.49e-03 |
| pod1_ko_up | Up-regulated in glomeruli isolated from Pod1 knockout mice, versus wild-type controls | 508 | 1.26 | 6 | 4.78 | 1.85e-03 |
| cancer_undifferentiated_meta_up | Sixty-nine genes commonly upregulated in undifferentiated cancer relative to well-differentiated cancer, from a meta-analysis of the OncoMine gene expression database | 98 | 0.24 | 3 | 12.38 | 1.93e-03 |
| oldwerner_fibro_up | Commonly upregulated in fibroblasts from Werner Syndrome and old individuals, compared to young | 30 | 0.07 | 2 | 26.97 | 2.54e-03 |
| 5azac-tsa_hepg2_dn | Down-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC) and 24 hrs treatment with both 5azaC and 500 nM trichostatin A (TSA). | 2343 | 5.79 | 14 | 2.42 | 2.63e-03 |
| scchn_hpvpos_up | Up-regulated in HPV-positive squamous cell carcinomas of the head and neck (SCCHN) vs. normal oral epithelium. | 31 | 0.08 | 2 | 26.10 | 2.71e-03 |
| cancer_neoplastic_meta_up | Sixty-seven genes commonly upregulated in cancer relative to normal tissue, from a meta-analysis of the OncoMine gene expression database | 115 | 0.28 | 3 | 10.55 | 3.03e-03 |
| human_tissue_testis | Genes expressed specifically in human testis tissue | 122 | 0.30 | 3 | 9.95 | 3.58e-03 |
| uvb_nhek1_c6 | Downregulated by UV-B light in normal human epidermal keratinocytes, cluster 6 | 268 | 0.66 | 4 | 6.04 | 4.68e-03 |
| csb_robust_up | Up-regulated robustly by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (9 of 9 pairwise comparisons). | 140 | 0.35 | 3 | 8.67 | 5.25e-03 |
| uvc_high_all_dn | Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9) | 634 | 1.57 | 6 | 3.83 | 5.41e-03 |
| et743_sarcoma_dn | Down-regulated following treatment with Et-743 at any timepoint in at least 8 of 11 sarcoma cell lines | 459 | 1.13 | 5 | 4.41 | 6.09e-03 |
| tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 3.27 | 9 | 2.76 | 6.41e-03 |
| p21_any_dn | Down-regulated at any timepoint (4-24 hrs) follwing ectopic expression of p21 (CDKN1A) in OvCa cells | 50 | 0.12 | 2 | 16.18 | 6.92e-03 |
| bay_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 1.17 | 5 | 4.26 | 7.01e-03 |
| et743_sarcoma_48hrs_dn | Down-regulated at48 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 304 | 0.75 | 4 | 5.32 | 7.25e-03 |
| prmt5_kd_up | Up-regulated by stable RNAi knock-down of PRMT5 in NIH 3T3 cells | 306 | 0.76 | 4 | 5.29 | 7.41e-03 |
| brca_prognosis_neg | Genes whose expression is consistently negatively correlated with breast cancer outcomes - higher expression is associated with metastasis and poor prognosis | 166 | 0.41 | 3 | 7.31 | 8.38e-03 |
| uvb_nhek3_c0 | Regulated by UV-B light in normal human epidermal keratinocytes, cluster 0 | 167 | 0.41 | 3 | 7.27 | 8.52e-03 |
| hippocampus_development_prenatal | Highly expressed in prenatal mouse hippocampus (cluster 1) | 58 | 0.14 | 2 | 13.95 | 9.21e-03 |
| csb_reliable_up | Up-regulated reliably by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (7 of 9 pairwise comparisons). | 513 | 1.27 | 5 | 3.94 | 9.56e-03 |