L2L Microarray Analysis Tool
Results for L01A.profile.u50
| Results summary | View all lists in L2L MDB | View all genes in L01A.profile.u50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 18 | 12.28 | 3.06e-14 |
| alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 18 | 12.28 | 3.06e-14 |
| heatshock_hela_2hr_up | Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 177 | 0.44 | 10 | 22.86 | 3.76e-11 |
| tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 3.27 | 20 | 6.12 | 3.19e-10 |
| bay_pbmc_6hr_up | Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 1.17 | 13 | 11.07 | 3.81e-10 |
| et743pt650_colonca_up | Upregulated by both Et-743 and Pt-650 in HCT116 cells (Fig. 6D) | 13 | 0.03 | 4 | 124.47 | 2.62e-08 |
| heat_glioblastoma_up | Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). | 78 | 0.19 | 6 | 31.12 | 5.03e-08 |
| bap_hepg2_up | Up-regulated at least 1.4-fold following treatment of HepG2 human hepatocellular carcinoma cells with carcinogen benzo(a)pyrene (BaP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. | 83 | 0.21 | 6 | 29.24 | 7.32e-08 |
| il2_pbmc_6hr_up | Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 530 | 1.31 | 11 | 8.40 | 1.36e-07 |
| heatshock_hela_4hr_up | Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 675 | 1.67 | 12 | 7.19 | 1.95e-07 |
| bleo_human_lymph_high_4hrs_up | Up-regulated at 4 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin | 32 | 0.08 | 4 | 50.57 | 1.27e-06 |
| pgj2_up | Upregulated by treatment with the prostaglandin 15d-PGJ2 | 12 | 0.03 | 3 | 101.14 | 3.27e-06 |
| oxstress_breastca_up | Upregulated by H2O2, Menadione and t-BH in breast cancer cells | 45 | 0.11 | 4 | 35.96 | 5.13e-06 |
| il2_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 646 | 1.60 | 10 | 6.26 | 6.69e-06 |
| il2_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 511 | 1.26 | 9 | 7.12 | 6.92e-06 |
| bleo_human_lymph_high_24hrs_up | Up-regulated at 24 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin | 197 | 0.49 | 6 | 12.32 | 1.15e-05 |
| csb_robust_up | Up-regulated robustly by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (9 of 9 pairwise comparisons). | 140 | 0.35 | 5 | 14.45 | 2.92e-05 |
| tgfb_hmvec_2hr_dn | Down-regulated 2 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 353 | 0.87 | 7 | 8.02 | 3.42e-05 |
| il2_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 510 | 1.26 | 8 | 6.35 | 5.00e-05 |
| csb_reliable_up | Up-regulated reliably by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (7 of 9 pairwise comparisons). | 513 | 1.27 | 8 | 6.31 | 5.21e-05 |
| tzd_adip_dn | Downregulated by treatment of mature murine adipocytes with the PPARgamma agonist troglitazone | 29 | 0.07 | 3 | 41.85 | 5.26e-05 |
| bleo_human_lymph_low_24hrs_up | Up-regulated at 24 hours following treatment of human lymphocytes (TK6) with a low dose of bleomycin | 5 | 0.01 | 2 | 161.82 | 6.08e-05 |
| mms_human_lymph_high_24hrs_up | Up-regulated at 24 hours following treatment of human lymphocytes (TK6) with a high dose of methyl methanesulfonate (MMS) | 32 | 0.08 | 3 | 37.93 | 7.10e-05 |
| lvad_heartfailure_up | Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device | 180 | 0.44 | 5 | 11.24 | 9.60e-05 |
| et743_hela_up | Upregulated by Et-743 in HeLa cells | 99 | 0.24 | 4 | 16.35 | 1.17e-04 |
| idx_tsa_up_cluster1 | Strongly up-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 1) | 44 | 0.11 | 3 | 27.58 | 1.85e-04 |
| bay_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 1.17 | 7 | 5.96 | 2.14e-04 |
| p53genes_arrest | p53 transcriptional targets involved in cell cycle arrest | 10 | 0.02 | 2 | 80.91 | 2.71e-04 |
| adip_vs_preadip_up | Upregulated in mature murine adipocytes (7 day differentiation) vs. preadipocytes (6 hr differentiation) | 57 | 0.14 | 3 | 21.29 | 4.00e-04 |
| calres_presenillin_ko_hippocampus_up | Up-regulated by calorie restriction in the hippocampus of 8 month-old presenillin-1 and -2 conditional double knock-out mice, compared to normal-diet controls. | 137 | 0.34 | 4 | 11.81 | 4.04e-04 |
| bay_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 544 | 1.34 | 7 | 5.21 | 4.80e-04 |
| senescence_hela_up | Up-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. | 262 | 0.65 | 5 | 7.72 | 5.40e-04 |
| uvb_nhek3_all | Regulated by UV-B light in normal human epidermal keratinocytes | 751 | 1.86 | 8 | 4.31 | 6.70e-04 |
| uvc_low_a2_up | Up-regulated at 6-12 hours following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m^2) (cluster a2) | 17 | 0.04 | 2 | 47.59 | 8.11e-04 |
| tsa_panc50_up | 50 "most interesting" genes upregulated by TSA treatment in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells | 77 | 0.19 | 3 | 15.76 | 9.64e-04 |
| as3_hek293_up | Upregulated in HEK293 cells by treatment with arsenite | 19 | 0.05 | 2 | 42.58 | 1.02e-03 |
| cis_resist_lung_up | Transient up-regulation is associated with transient cisplatin resistance in a human squamous cell lung cancer line (NCI-H2170) | 21 | 0.05 | 2 | 38.53 | 1.24e-03 |
| bap_mcf7_up | Up-regulated at least 1.4-fold following treatment of MCF-7 human breast carcinoma cells with carcinogen benzo(a)pyrene (BaP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. | 87 | 0.22 | 3 | 13.95 | 1.37e-03 |
| hdaci_colon_sul_up | Upregulated by sulindac at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 192 | 0.47 | 4 | 8.43 | 1.42e-03 |
| brg1_alab_up | Up-regulated at 18 and 24 hours following adenovirus-mediated expression of BRG1 in ALAB breast cancer cells with mutant, inactive BRG1 | 91 | 0.22 | 3 | 13.34 | 1.56e-03 |
| bay_pbmc_24hr_up | Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 202 | 0.50 | 4 | 8.01 | 1.70e-03 |
| bay-il2_pbmc_late_dn | Down-regulated at 24-48 hours following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist, compared to recombinant IL-2. | 205 | 0.51 | 4 | 7.89 | 1.80e-03 |
| alk5_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 0.86 | 5 | 5.83 | 1.87e-03 |
| alk5_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 0.86 | 5 | 5.83 | 1.87e-03 |
| cmv_hcmv_timecourse_all_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) | 895 | 2.21 | 8 | 3.62 | 2.01e-03 |
| uvb_nhek1_c2 | Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 2 | 28 | 0.07 | 2 | 28.90 | 2.21e-03 |
| cis_resist_gastric_up | Upregulated in gastric cancer cell lines reistant to cisplatin, compared to parent chemosensitive lines | 29 | 0.07 | 2 | 27.90 | 2.37e-03 |
| heatshock_hela_2hr_dn | Down-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 223 | 0.55 | 4 | 7.26 | 2.44e-03 |
| uvc_xpcs_8hr_up | Up-regulated at 8 hours following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC | 108 | 0.27 | 3 | 11.24 | 2.54e-03 |
| uvc_xpcs_all_up | Up-regulated at any timepoint following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC | 112 | 0.28 | 3 | 10.84 | 2.82e-03 |
| p53genes_all | p53 transcriptional targets | 33 | 0.08 | 2 | 24.52 | 3.07e-03 |
| uvc_low_all_up | Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m^2) (clusters a1-a4) | 33 | 0.08 | 2 | 24.52 | 3.07e-03 |
| uvc_high_all_up | Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) | 34 | 0.08 | 2 | 23.80 | 3.25e-03 |
| aged_mouse_retina_any_up | Up-regulated in the retina of 16-month aged mice from any of four strains (S8, S10, SR1, B6J), versus 3-month young controls | 36 | 0.09 | 2 | 22.47 | 3.64e-03 |
| but_tsa_up | Upregulated by the combination of TSA and butyrate in HT-29 cells | 36 | 0.09 | 2 | 22.47 | 3.64e-03 |
| hpve7_hpve6_hfk_dn | Down-regulated in human foreskin keratinocytes expressing both HPV E6 and E7 proteins compared to E7 expression only | 39 | 0.10 | 2 | 20.75 | 4.26e-03 |
| bay_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 606 | 1.50 | 6 | 4.01 | 4.37e-03 |
| tcell_anergic_up | Genes up-regulated in anergic mouse T helper cells (A.E7), versus non-anergic stimulated controls | 132 | 0.33 | 3 | 9.19 | 4.46e-03 |
| tsa_cd4_up | Up-regulated in mouse CD4+ T-cells following 4 hour treatment with 100 nM trichostatin A | 43 | 0.11 | 2 | 18.82 | 5.16e-03 |
| hdaci_colon_sul48hrs_up | Upregulated by sulindac at 48 hrs in SW260 colon carcinoma cells | 140 | 0.35 | 3 | 8.67 | 5.25e-03 |
| uvb_nhek4_6hrs_up | Upregulated at 6 hours by UV-B light in normal human epidermal keratinocytes | 49 | 0.12 | 2 | 16.51 | 6.65e-03 |
| brca1_sw480_up | Up-regulated by infection of human colon adenocarcinoma cells (SW480) with Ad-BRCA1, versus Ad-LacZ control | 50 | 0.12 | 2 | 16.18 | 6.92e-03 |
| aged_mouse_muscle_up | Upregulated in the gastrocnemius muscle of aged adult mice (30-month) vs. young adult (5-month) | 51 | 0.13 | 2 | 15.86 | 7.19e-03 |
| hypoxia_review | Genes known to be induced by hypoxia | 160 | 0.40 | 3 | 7.59 | 7.58e-03 |
| vegf_huvec_2hrs_up | Up-regulated 2 hours after VEGF treatment in human umbilical vein endothelial cells | 54 | 0.13 | 2 | 14.98 | 8.03e-03 |
| uvb_nhek3_c0 | Regulated by UV-B light in normal human epidermal keratinocytes, cluster 0 | 167 | 0.41 | 3 | 7.27 | 8.52e-03 |
| bap_hepg2_dn | Down-regulated at least 1.4-fold following treatment of HepG2 human hepatocellular carcinoma cells with carcinogen benzo(a)pyrene (BaP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. | 56 | 0.14 | 2 | 14.45 | 8.61e-03 |
| csb_robust_dn | Down-regulated robustly by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (9 of 9 pairwise comparisons). | 169 | 0.42 | 3 | 7.18 | 8.80e-03 |
| zmpste24_ko_up | Fifty genes most strongly up-regulated in liver tissue from mice deficient in the lamin-protease Zmpste24/Face1, versus wild-type controls | 57 | 0.14 | 2 | 14.19 | 8.91e-03 |