L2L Microarray Analysis Tool

Results summary	View all lists in GO:BiolProc	View all genes in L01A.profile.u50

List Name	Description	Total probes	Expected matches	Actual matches	Fold Enrichment	Binomial p-value
glutathione biosynthetic process	The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.	10	0.02	2	80.91	2.71e-04
carboxylic acid metabolic process	The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).	679	1.68	8	4.77	3.48e-04
organic acid metabolic process	The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.	681	1.68	8	4.75	3.54e-04
response to heat	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.	15	0.04	2	53.94	6.28e-04
cholesterol absorption	Uptake of cholesterol into the blood by absorption from the small intestine.	15	0.04	2	53.94	6.28e-04
lipid digestion	The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested lipids into components that may be easily absorbed and directed into metabolism.	15	0.04	2	53.94	6.28e-04
glutathione metabolic process	The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.	16	0.04	2	50.57	7.17e-04
cell death	The specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.	1152	2.85	10	3.51	7.34e-04
death	A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism.	1152	2.85	10	3.51	7.34e-04
glutamate metabolic process	The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid.	17	0.04	2	47.59	8.11e-04
monocarboxylic acid metabolic process	The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-).	307	0.76	5	6.59	1.10e-03
response to unfolded protein	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.	83	0.21	3	14.62	1.20e-03
response to protein stimulus	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein stimulus.	83	0.21	3	14.62	1.20e-03
intestinal absorption	The processes by which nutrients are taken up from the contents of the intestine.	21	0.05	2	38.53	1.24e-03
programmed cell death	Cell death resulting from activation of endogenous cellular processes.	1086	2.68	9	3.35	1.81e-03
organic acid transport	The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of, within or between cells.	97	0.24	3	12.51	1.87e-03
carboxylic acid transport	The directed movement of carboxylic acids into, out of, within or between cells. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).	97	0.24	3	12.51	1.87e-03
sulfur amino acid metabolic process	The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine.	28	0.07	2	28.90	2.21e-03
digestion	The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.	106	0.26	3	11.45	2.41e-03
digestive process	A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.	30	0.07	2	26.97	2.54e-03
prostanoid metabolic process	The chemical reactions and pathways involving prostanoids, any compound based on or derived from the prostanoate structure.	31	0.08	2	26.10	2.71e-03
prostaglandin metabolic process	The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities.	31	0.08	2	26.10	2.71e-03
steroid metabolic process	The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.	234	0.58	4	6.92	2.90e-03
serine family amino acid metabolic process	The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.	34	0.08	2	23.80	3.25e-03
response to temperature stimulus	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus.	39	0.10	2	20.75	4.26e-03
response to chemical stimulus	A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.	603	1.49	6	4.03	4.26e-03
regulation of blood vessel size	Any process that modulates the size of blood vessels.	43	0.11	2	18.82	5.16e-03
regulation of I-kappaB kinase/NF-kappaB cascade	Any process that modulates an I-kappaB kinase/NF-kappaB induced cascade.	142	0.35	3	8.55	5.46e-03
apoptosis	A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface.	1078	2.66	8	3.00	6.07e-03
sulfur compound biosynthetic process	The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.	49	0.12	2	16.51	6.65e-03
lipid metabolic process	The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.	877	2.17	7	3.23	6.84e-03
protein folding	The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.	319	0.79	4	5.07	8.55e-03
icosanoid metabolic process	The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids.	58	0.14	2	13.95	9.21e-03
glutamine family amino acid metabolic process	The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.	60	0.15	2	13.48	9.83e-03
cellular lipid metabolic process	The chemical reactions and pathways involving lipids, as carried out by individual cells.	723	1.79	6	3.36	9.95e-03

glutathione biosynthetic process

The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.

10

0.02

2

80.91

2.71e-04

carboxylic acid metabolic process

The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).

679

1.68

8

4.77

3.48e-04

organic acid metabolic process

The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.

681

1.68

8

4.75

3.54e-04

response to heat

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.

15

0.04

2

53.94

6.28e-04

cholesterol absorption

Uptake of cholesterol into the blood by absorption from the small intestine.

15

0.04

2

53.94

6.28e-04

lipid digestion

The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested lipids into components that may be easily absorbed and directed into metabolism.

15

0.04

2

53.94

6.28e-04

glutathione metabolic process

The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.

16

0.04

2

50.57

7.17e-04

cell death

The specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.

1152

2.85

10

3.51

7.34e-04

death

A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism.

1152

2.85

10

3.51

7.34e-04

glutamate metabolic process

The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid.

17

0.04

2

47.59

8.11e-04

monocarboxylic acid metabolic process

The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-).

307

0.76

5

6.59

1.10e-03

response to unfolded protein

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.

83

0.21

3

14.62

1.20e-03

response to protein stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein stimulus.

83

0.21

3

14.62

1.20e-03

intestinal absorption

The processes by which nutrients are taken up from the contents of the intestine.

21

0.05

2

38.53

1.24e-03

programmed cell death

Cell death resulting from activation of endogenous cellular processes.

1086

2.68

9

3.35

1.81e-03

organic acid transport

The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of, within or between cells.

97

0.24

3

12.51

1.87e-03

carboxylic acid transport

The directed movement of carboxylic acids into, out of, within or between cells. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).

97

0.24

3

12.51

1.87e-03

sulfur amino acid metabolic process

The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine.

28

0.07

2

28.90

2.21e-03

digestion

The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.

106

0.26

3

11.45

2.41e-03

digestive process

A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.

30

0.07

2

26.97

2.54e-03

prostanoid metabolic process

The chemical reactions and pathways involving prostanoids, any compound based on or derived from the prostanoate structure.

31

0.08

2

26.10

2.71e-03

prostaglandin metabolic process

The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities.

31

0.08

2

26.10

2.71e-03

steroid metabolic process

The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

234

0.58

4

6.92

2.90e-03

serine family amino acid metabolic process

The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.

34

0.08

2

23.80

3.25e-03

response to temperature stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus.

39

0.10

2

20.75

4.26e-03

response to chemical stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.

603

1.49

6

4.03

4.26e-03

regulation of blood vessel size

Any process that modulates the size of blood vessels.

43

0.11

2

18.82

5.16e-03

regulation of I-kappaB kinase/NF-kappaB cascade

Any process that modulates an I-kappaB kinase/NF-kappaB induced cascade.

142

0.35

3

8.55

5.46e-03

apoptosis

A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface.

1078

2.66

8

3.00

6.07e-03

sulfur compound biosynthetic process

The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.

49

0.12

2

16.51

6.65e-03

lipid metabolic process

The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.

877

2.17

7

3.23

6.84e-03

protein folding

The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.

319

0.79

4

5.07

8.55e-03

icosanoid metabolic process

The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids.

58

0.14

2

13.95

9.21e-03