L2L L2L Microarray Analysis Tool

Results for J05A.profile.ud50

Results summary View all lists in L2L MDB View all genes in J05A.profile.ud50
List Name Description Total
probes
Expected
matches
Actual
matches
Fold
Enrichment
Binomial
p-value
dox_resist_gastric_up Upregulated in gastric cancer cell lines reistant to doxorubicin, compared to parent chemosensitive lines 74 0.37 6 16.40 2.03e-06
senescence_hff_dn Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). 299 1.48 10 6.76 3.23e-06
p21_p53_early_dn Down-regulated at early timepoints (4-8 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent 23 0.11 4 35.18 4.91e-06
senescence_rep-ind_dn Down-regulated in models of both replicative (high-passge human foreskin fibroblast) and induced (repression of E7 in HeLa) cellular senescence. 171 0.85 7 8.28 2.67e-05
serum_fibroblast_cellcycle Cell-cycle dependent genes regulated following exposure to serum in a variety of human fibroblast cell lines 197 0.97 7 7.19 6.53e-05
idx_tsa_up_cluster3 Strongly up-regulated at 16-24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 3) 136 0.67 6 8.92 6.63e-05
senescence_hela_dn Down-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. 341 1.69 8 4.75 3.49e-04
p21_p53_any_dn Down-regulated at any timepoint (4-24 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent 77 0.38 4 10.51 6.06e-04
genotoxins_all_4hrs_reg Genes regulated in mouse lymphocytes (TK 3.7.2C) at 4 hours by all six genotoxins tested (cisplatin, methyl methanesulfonate, mitomycin C, taxol, hydroxyurea and etoposide) 45 0.22 3 13.48 1.47e-03
dac_cgi_fibro_dn Downregulated by DAC treatment in LD419 fibroblast cells, with 5' CpG island 12 0.06 2 33.71 1.56e-03
idx_tsa_dn_cluster6 Strongly down-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 6) 48 0.24 3 12.64 1.77e-03
p21_early_dn Down-regulated at early timepoints (4-8 hrs) follwing ectopic expression of p21 (CDKN1A) in OvCa cells 16 0.08 2 25.28 2.80e-03
dac_fibro_dn Downregulated by DAC treatment in LD419 fibroblast cells 17 0.08 2 23.80 3.16e-03
reovirus_hek293_dn Down-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney 488 2.41 8 3.32 3.35e-03
prmt5_kd_up Up-regulated by stable RNAi knock-down of PRMT5 in NIH 3T3 cells 306 1.51 6 3.97 4.52e-03
adip_diff_cluster5 Strongly upregulated at 24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 5) 67 0.33 3 9.06 4.57e-03
middleage_dn Downregulated in fibroblasts from middle-age individuals, compared to young 23 0.11 2 17.59 5.77e-03
oldage_dn Downregulated in fibroblasts from old individuals, compared to young 76 0.38 3 7.98 6.49e-03
tgfbeta_c4_up Upregulated by TGF-beta treatment of skin fibroblasts, cluster 4 26 0.13 2 15.56 7.34e-03
alk5_hmvec_2hr_up Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 347 1.72 6 3.50 8.16e-03
alk5_hmvec_4hr_up Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 347 1.72 6 3.50 8.16e-03
irs1_ko_adip_up Up-regulated in brown preadipocytes from Irs1-knockout mice, which display severe defects in adipocyte differentiation, versus wild-type controls 159 0.79 4 5.09 8.35e-03
cox2_ko_hippocampus_dn Down-regulated in the hippocampus of COX2-/- mice compared to wild-type controls. 84 0.42 3 7.22 8.55e-03
aged_mouse_cerebellum_dn Downregulated in the cerebellum of aged adult mice (30-month) vs. young adult (5-month) 87 0.43 3 6.97 9.41e-03

Raw data (tab-delimited .txt)