Results summary | View all lists in L2L MDB | View all genes in J05A.profile.d50 |
List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
---|---|---|---|---|---|---|
dox_resist_gastric_up | Upregulated in gastric cancer cell lines reistant to doxorubicin, compared to parent chemosensitive lines | 74 | 0.18 | 6 | 32.80 | 3.66e-08 |
senescence_hff_dn | Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). | 299 | 0.74 | 7 | 9.47 | 1.19e-05 |
p21_p53_early_dn | Down-regulated at early timepoints (4-8 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent | 23 | 0.06 | 3 | 52.77 | 2.58e-05 |
senescence_rep-ind_dn | Down-regulated in models of both replicative (high-passge human foreskin fibroblast) and induced (repression of E7 in HeLa) cellular senescence. | 171 | 0.42 | 5 | 11.83 | 7.54e-05 |
serum_fibroblast_cellcycle | Cell-cycle dependent genes regulated following exposure to serum in a variety of human fibroblast cell lines | 197 | 0.49 | 5 | 10.27 | 1.46e-04 |
senescence_hela_dn | Down-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. | 341 | 0.84 | 6 | 7.12 | 2.36e-04 |
idx_tsa_dn_cluster6 | Strongly down-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 6) | 48 | 0.12 | 3 | 25.28 | 2.40e-04 |
idx_tsa_up_cluster3 | Strongly up-regulated at 16-24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 3) | 136 | 0.34 | 4 | 11.90 | 3.93e-04 |
dac_cgi_fibro_dn | Downregulated by DAC treatment in LD419 fibroblast cells, with 5' CpG island | 12 | 0.03 | 2 | 67.42 | 3.97e-04 |
adip_diff_cluster5 | Strongly upregulated at 24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 5) | 67 | 0.17 | 3 | 18.11 | 6.43e-04 |
p21_early_dn | Down-regulated at early timepoints (4-8 hrs) follwing ectopic expression of p21 (CDKN1A) in OvCa cells | 16 | 0.04 | 2 | 50.57 | 7.17e-04 |
dac_fibro_dn | Downregulated by DAC treatment in LD419 fibroblast cells | 17 | 0.04 | 2 | 47.59 | 8.11e-04 |
p21_p53_any_dn | Down-regulated at any timepoint (4-24 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent | 77 | 0.19 | 3 | 15.76 | 9.64e-04 |
prmt5_kd_up | Up-regulated by stable RNAi knock-down of PRMT5 in NIH 3T3 cells | 306 | 0.76 | 5 | 6.61 | 1.08e-03 |
middleage_dn | Downregulated in fibroblasts from middle-age individuals, compared to young | 23 | 0.06 | 2 | 35.18 | 1.49e-03 |
pubertal_mammary_6-7wks_dn | Down-regulated > 1.5-fold in the developing mouse mammary gland between 6 and 7 weeks of age. | 106 | 0.26 | 3 | 11.45 | 2.41e-03 |
stemcell_embryonic_up | Enriched in mouse embryonic stem cells, compared to differentiated brain and bone marrow cells | 1989 | 4.92 | 12 | 2.44 | 4.74e-03 |
genotoxins_all_4hrs_reg | Genes regulated in mouse lymphocytes (TK 3.7.2C) at 4 hours by all six genotoxins tested (cisplatin, methyl methanesulfonate, mitomycin C, taxol, hydroxyurea and etoposide) | 45 | 0.11 | 2 | 17.98 | 5.64e-03 |
p21_any_dn | Down-regulated at any timepoint (4-24 hrs) follwing ectopic expression of p21 (CDKN1A) in OvCa cells | 50 | 0.12 | 2 | 16.18 | 6.92e-03 |
hematop_stem_all_up | Up-regulated in populations of human hematopoietic stem cells (CD34+/CD38-/Lin-) from bone marrow, umbilical cord blood, and peripheral blood stem-progenitor cells, compared to the stem cell-depleted population (CD34+/[CD38/Lin++]) | 52 | 0.13 | 2 | 15.56 | 7.46e-03 |
reovirus_hek293_dn | Down-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney | 488 | 1.21 | 5 | 4.14 | 7.82e-03 |