L2L L2L Microarray Analysis Tool

Results for H02A.profile.ud50

Results summary View all lists in L2L MDB View all genes in H02A.profile.ud50
List Name Description Total
probes
Expected
matches
Actual
matches
Fold
Enrichment
Binomial
p-value
lvad_heartfailure_up Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device 180 0.89 12 13.48 1.64e-10
dex_keratinocyte_1hr_dn Down-regulated in primary human keratinocytes at 1 hour following treatment with 0.1 microM dexamethasone 24 0.12 5 42.14 1.16e-07
idx_tsa_up_cluster1 Strongly up-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 1) 44 0.22 5 22.99 2.73e-06
hdaci_colon_cluster2 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 2) 9 0.04 3 67.42 9.93e-06
cmv_all_dn Downregulated at any timepoint following infection of primary human foreskin fibroblasts with CMV 213 1.05 8 7.60 1.34e-05
hdaci_colon_but_up Upregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells 233 1.15 8 6.94 2.54e-05
dex_keratinocyte_4hr_dn Down-regulated in primary human keratinocytes at 4 hours following treatment with 0.1 microM dexamethasone 69 0.34 5 14.66 2.55e-05
fsh_rat_granulosa_up Up-regulated by FSH in immortalized rat granulosa cells (rFSH-17) 15 0.07 3 40.45 5.26e-05
ribavirin_rsv_dn Up-regulation by infection of human pulmonary epithelian cells (A549) with respiratory syncytial virus (RSV) is inhibited by the anti-viral drug ribavirin 101 0.50 5 10.01 1.58e-04
il2_pbmc_4hr_up Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 510 2.52 10 3.97 2.82e-04
cmv_hcmv_timecourse_all_dn Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) 839 4.15 13 3.13 3.67e-04
hdaci_colon_but48hrs_up Upregulated by butyrate at 48 hrs in SW260 colon carcinoma cells 135 0.67 5 7.49 6.01e-04
hdaci_colon_cluster9 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 9, associated with histone hyperAc) 78 0.39 4 10.37 6.37e-04
heat_glioblastoma_up Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). 78 0.39 4 10.37 6.37e-04
cmv_24hrs_dn Downregulated at 24hrs following infection of primary human foreskin fibroblasts with CMV 140 0.69 5 7.22 7.09e-04
il2_pbmc_24hr_up Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 503 2.49 9 3.62 1.06e-03
bay_pbmc_48hr_dn Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 318 1.57 7 4.45 1.16e-03
hdaci_colon_but24hrs_up Upregulated by butyrate at 24 hrs in SW260 colon carcinoma cells 95 0.47 4 8.52 1.33e-03
il2_pbmc_48hr_dn Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 531 2.63 9 3.43 1.53e-03
o6bg_resist_medulloblastoma_up Up-regulated in a medulloblastoma cell line resistant to both BCNU and O6-BG, compared to sensitive parent line (D-341 MED) 46 0.23 3 13.19 1.56e-03
idx_tsa_dn_cluster6 Strongly down-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 6) 48 0.24 3 12.64 1.77e-03
alk5_hmvec_2hr_up Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 347 1.72 7 4.08 1.91e-03
alk5_hmvec_4hr_up Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 347 1.72 7 4.08 1.91e-03
emt_up Up-regulated during the TGFbeta-induced epithelial-to-mesenchymal transition (EMT) of Ras-transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late-stage tumor progression and metastasis) 105 0.52 4 7.71 1.92e-03
ageing_brain_up Age-upregulated in the human frontal cortex 446 2.20 8 3.63 1.94e-03
heatshock_hela_4hr_up Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 675 3.34 10 3.00 2.31e-03
arthritis_mouse_common_up Up-regulated in joint tissue from both severely arthritic HTLV-I transgenic mice and IL-1Ra knock-out mice, versus wild-type littermate controls. 459 2.27 8 3.53 2.31e-03
cis_xpc_dn Reduced expression in XPC-defective fibroblasts, compared to normal fibroblasts, following treatment with cisplatin 363 1.79 7 3.90 2.45e-03
adipogenesis_hmsc_class2_up Up-regulated 1-14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class II) 15 0.07 2 26.97 2.46e-03
bay_pbmc_24hr_up Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 202 1.00 5 5.01 3.53e-03
bay_pbmc_2hr_up Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 606 3.00 9 3.00 3.67e-03
cmv-uv_hcmv_6hrs_dn Down-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus 207 1.02 5 4.89 3.91e-03
as3_hek293_up Upregulated in HEK293 cells by treatment with arsenite 19 0.09 2 21.29 3.95e-03
adip_diff_cluster2 Strongly upregulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 2) 64 0.32 3 9.48 4.02e-03
et743pt650_breastca_dn Downregulated by both Et-743 and Pt-650 in MDA-MB-435 cells (Fig. 6G) 20 0.10 2 20.23 4.38e-03
il2_pbmc_48hr_up Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 511 2.53 8 3.17 4.40e-03
tnfalpha_30min_up Upregulated 30min after TNF-alpha treatment of HeLa cells 68 0.34 3 8.92 4.77e-03
il2_pbmc_24hr_dn Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 646 3.19 9 2.82 5.51e-03
bay_pbmc_4hr_up Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 544 2.69 8 2.97 6.33e-03
stress_tpa_specific_up Genes up-regulated 4 hours following TPA treatment that discriminate TPA from other stress agents 78 0.39 3 7.78 6.98e-03
calres_mouse_dn Downregulated in the gastrocnemius muscle of aged (30-month) mice subjected to caloric restriction since young adulthood vs. age-matched controls 79 0.39 3 7.68 7.22e-03
hdaci_colon_tsabut_up Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 79 0.39 3 7.68 7.22e-03
cmv_hcmv_timecourse_24hrs_dn Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 24 hours 82 0.41 3 7.40 8.00e-03
tgfb_hmvec_2hr_dn Down-regulated 2 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. 353 1.75 6 3.44 8.83e-03
tzd_adip_dn Downregulated by treatment of mature murine adipocytes with the PPARgamma agonist troglitazone 29 0.14 2 13.95 9.08e-03
uvb_nhek3_c7 Regulated by UV-B light in normal human epidermal keratinocytes, cluster 7 86 0.43 3 7.06 9.11e-03
uv-cmv_unique_hcmv_6hrs_dn Down-regulated in fibroblasts at 6 hours following infection with UV-inactivated CMV, but not untreated CMV 164 0.81 4 4.93 9.29e-03
diab_neph_dn Downregulated in the glomeruli of cadaver kidneys from patients with diabetic nephropathy, compared to normal controls 829 4.10 10 2.44 9.34e-03
cmv_hcmv_timecourse_20hrs_dn Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 20 hours 87 0.43 3 6.97 9.41e-03
hdaci_colon_but2hrs_up Upregulated by butyrate at 2 hrs in SW260 colon carcinoma cells 87 0.43 3 6.97 9.41e-03

Raw data (tab-delimited .txt)