L2L L2L Microarray Analysis Tool

Results for G03D.profile.u50

Results summary View all lists in L2L MDB View all genes in G03D.profile.u50
List Name Description Total
probes
Expected
matches
Actual
matches
Fold
Enrichment
Binomial
p-value
lvad_heartfailure_up Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device 180 0.44 7 15.73 4.19e-07
fsh_human_granulosa_up Up-regulated by FSH in primary human granulosa cells (rFSH-17) 31 0.08 4 52.20 1.11e-06
adipocyte_brca_up Upregulated in breast cancer cells (MCF-7) treated with adipocyte-conditioned growth media 14 0.03 3 86.69 5.39e-06
as3_hek293_up Upregulated in HEK293 cells by treatment with arsenite 19 0.05 3 63.87 1.42e-05
alk1_hmvec_2hr_up Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 593 1.47 9 6.14 2.23e-05
alk1_hmvec_4hr_up Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 593 1.47 9 6.14 2.23e-05
heatshock_hela_4hr_up Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 675 1.67 9 5.39 6.01e-05
stress_arsenic_specific_up Genes up-regulated 4 hours following arsenic treatment that discriminate arsenic from other stress agents 266 0.66 6 9.12 6.13e-05
uvb_nhek3_c7 Regulated by UV-B light in normal human epidermal keratinocytes, cluster 7 86 0.21 4 18.82 6.74e-05
uvc_low_all_up Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m^2) (clusters a1-a4) 33 0.08 3 36.78 7.80e-05
uvc_low_a3_up Up-regulated at 12 hours following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m^2) (cluster a3) 6 0.01 2 134.85 9.11e-05
hdaci_three_up Upregulated in several cell lines by all of TSA, SAHA, and MS-275 8 0.02 2 101.14 1.69e-04
idx_tsa_up_cluster1 Strongly up-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 1) 44 0.11 3 27.58 1.85e-04
cmv_hcmv_timecourse_12hrs_up Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 12 hours 45 0.11 3 26.97 1.98e-04
oxstress_breastca_up Upregulated by H2O2, Menadione and t-BH in breast cancer cells 45 0.11 3 26.97 1.98e-04
cmv_hcmv_6hrs_up Up-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus (CMV) 46 0.11 3 26.38 2.12e-04
o6bg_resist_medulloblastoma_up Up-regulated in a medulloblastoma cell line resistant to both BCNU and O6-BG, compared to sensitive parent line (D-341 MED) 46 0.11 3 26.38 2.12e-04
vcr_res_xenografts_dn Down-regulation is correlated with resistance of human cancer xenografts to vincristine 9 0.02 2 89.90 2.17e-04
alk5_hmvec_2hr_up Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 347 0.86 6 6.99 2.58e-04
alk5_hmvec_4hr_up Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 347 0.86 6 6.99 2.58e-04
hdaci_colon_tsa2hrs_up Upregulated by TSA at 2 hrs in SW260 colon carcinoma cells 61 0.15 3 19.90 4.88e-04
sarcomas_liposarcoma_up Top 20 positive significant genes associated with liposarcomas, versus other soft-tissue tumors. 14 0.03 2 57.79 5.45e-04
et743_blockstsa Normally induced by the HDACi TSA, but induction is blocked by Et-743 15 0.04 2 53.94 6.28e-04
fsh_rat_granulosa_up Up-regulated by FSH in immortalized rat granulosa cells (rFSH-17) 15 0.04 2 53.94 6.28e-04
uvb_nhek3_all Regulated by UV-B light in normal human epidermal keratinocytes 751 1.86 8 4.31 6.70e-04
uvc_high_d8_dn Progressively down-regulated through 18 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d8) 70 0.17 3 17.34 7.31e-04
bay_pbmc_2hr_up Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 606 1.50 7 4.67 9.00e-04
ageing_brain_up Age-upregulated in the human frontal cortex 446 1.10 6 5.44 9.57e-04
tsa_panc50_up 50 "most interesting" genes upregulated by TSA treatment in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells 77 0.19 3 15.76 9.64e-04
hdaci_colon_tsabut_up Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 79 0.20 3 15.36 1.04e-03
hypoxia_reg_up Upregulated by hypoxia in renal cells, and downregulated with reoxygenation 80 0.20 3 15.17 1.08e-03
hdaci_colon_but2hrs_up Upregulated by butyrate at 2 hrs in SW260 colon carcinoma cells 87 0.22 3 13.95 1.37e-03
reovirus_hek293_up Up-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney 491 1.21 6 4.94 1.56e-03
dex_keratinocyte_1hr_dn Down-regulated in primary human keratinocytes at 1 hour following treatment with 0.1 microM dexamethasone 24 0.06 2 33.71 1.63e-03
tgfb_hmvec_4hr_dn Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. 1321 3.27 10 3.06 2.00e-03
ifna_hcmv_6hrs_up Up-regulated in fibroblasts at 6 hours following treatment with interferon-alpha 103 0.25 3 11.78 2.22e-03
cmv-uv_hcmv_6hrs_up Up-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus 226 0.56 4 7.16 2.56e-03
adipogenesis_hmsc_class1_up Up-regulated 1 day following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class I) 31 0.08 2 26.10 2.71e-03
hdaci_colon_but_up Upregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells 233 0.58 4 6.94 2.85e-03
heartfailure_ventricles_dn Downregulated in the ventricles of failing hearts (DCM and ICM) compared to healthy controls 120 0.30 3 10.11 3.42e-03
hdaci_colon_tsa_up Upregulated by TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 122 0.30 3 9.95 3.58e-03
caries_pulp_up Up-regulated in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth 410 1.01 5 4.93 3.81e-03
cmvuv-cmv_common_hcmv_6hrs_up Up-regulated in fibroblasts at 6 hours following infection with either human cytomegalovirus (CMV) or UV-inactivated CMV 37 0.09 2 21.87 3.84e-03
nab_lung_up Up-regulated in human non-small cell lung carcinoma cell line H460 following 24-hour treatment with sodium butyrate 38 0.09 2 21.29 4.05e-03
uvb_nhek3_c8 Regulated by UV-B light in normal human epidermal keratinocytes, cluster 8 132 0.33 3 9.19 4.46e-03
xpb_ttd-cs_dn Down-regulated in XPB/TTD fibroblasts (expressing XPB-A355C), compared to XPB/CS fibroblasts (expressing XPB-T296C) 41 0.10 2 19.73 4.70e-03
il1_cornea_up Upregulated in corneal fibroblasts after interleukin-1 treatment (Tables 1 and 2) 136 0.34 3 8.92 4.85e-03
scw_joint_24hrs_up Up-regulated in rat ankle joints 24 hrs following intra-articular injection of Streptococcal cell wall (SCW), a rat model of arthritis. 143 0.35 3 8.49 5.57e-03
ifna_uv-cmv_common_hcmv_6hrs_up Up-regulated in fibroblasts at 6 hours following either infection with UV-inactivated CMV or interferon-alpha 47 0.12 2 17.21 6.14e-03
genotoxins_all_24hrs_reg Genes most consistently regulated in mouse lymphocytes (TK 3.7.2C) at 24 hours by all six genotoxins tested (cisplatin, methyl methanesulfonate, mitomycin C, taxol, hydroxyurea and etoposide) 49 0.12 2 16.51 6.65e-03
hypoxia_review Genes known to be induced by hypoxia 160 0.40 3 7.59 7.58e-03
scw_joint_react_up Up-regulated in rat ankle joints 16 days after intra-articular injection of Streptococcal cell wall (SCW), and 3 days after systemic injection of SCW to reactivate joint inflammation. 166 0.41 3 7.31 8.38e-03
nf90_up Upregulated by ectopic expression of NF90 in GHOST(3)CXCR4 cells 56 0.14 2 14.45 8.61e-03
dac_bladder_up Upregulated by DAC treatment in T24 bladder carcinoma cells 60 0.15 2 13.48 9.83e-03

Raw data (tab-delimited .txt)