Results summary | View all lists in L2L MDB | View all genes in G03D.profile.u50 |
List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
---|---|---|---|---|---|---|
lvad_heartfailure_up | Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device | 180 | 0.44 | 7 | 15.73 | 4.19e-07 |
fsh_human_granulosa_up | Up-regulated by FSH in primary human granulosa cells (rFSH-17) | 31 | 0.08 | 4 | 52.20 | 1.11e-06 |
adipocyte_brca_up | Upregulated in breast cancer cells (MCF-7) treated with adipocyte-conditioned growth media | 14 | 0.03 | 3 | 86.69 | 5.39e-06 |
as3_hek293_up | Upregulated in HEK293 cells by treatment with arsenite | 19 | 0.05 | 3 | 63.87 | 1.42e-05 |
alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 9 | 6.14 | 2.23e-05 |
alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 9 | 6.14 | 2.23e-05 |
heatshock_hela_4hr_up | Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 675 | 1.67 | 9 | 5.39 | 6.01e-05 |
stress_arsenic_specific_up | Genes up-regulated 4 hours following arsenic treatment that discriminate arsenic from other stress agents | 266 | 0.66 | 6 | 9.12 | 6.13e-05 |
uvb_nhek3_c7 | Regulated by UV-B light in normal human epidermal keratinocytes, cluster 7 | 86 | 0.21 | 4 | 18.82 | 6.74e-05 |
uvc_low_all_up | Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m^2) (clusters a1-a4) | 33 | 0.08 | 3 | 36.78 | 7.80e-05 |
uvc_low_a3_up | Up-regulated at 12 hours following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m^2) (cluster a3) | 6 | 0.01 | 2 | 134.85 | 9.11e-05 |
hdaci_three_up | Upregulated in several cell lines by all of TSA, SAHA, and MS-275 | 8 | 0.02 | 2 | 101.14 | 1.69e-04 |
idx_tsa_up_cluster1 | Strongly up-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 1) | 44 | 0.11 | 3 | 27.58 | 1.85e-04 |
cmv_hcmv_timecourse_12hrs_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 12 hours | 45 | 0.11 | 3 | 26.97 | 1.98e-04 |
oxstress_breastca_up | Upregulated by H2O2, Menadione and t-BH in breast cancer cells | 45 | 0.11 | 3 | 26.97 | 1.98e-04 |
cmv_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus (CMV) | 46 | 0.11 | 3 | 26.38 | 2.12e-04 |
o6bg_resist_medulloblastoma_up | Up-regulated in a medulloblastoma cell line resistant to both BCNU and O6-BG, compared to sensitive parent line (D-341 MED) | 46 | 0.11 | 3 | 26.38 | 2.12e-04 |
vcr_res_xenografts_dn | Down-regulation is correlated with resistance of human cancer xenografts to vincristine | 9 | 0.02 | 2 | 89.90 | 2.17e-04 |
alk5_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 0.86 | 6 | 6.99 | 2.58e-04 |
alk5_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 0.86 | 6 | 6.99 | 2.58e-04 |
hdaci_colon_tsa2hrs_up | Upregulated by TSA at 2 hrs in SW260 colon carcinoma cells | 61 | 0.15 | 3 | 19.90 | 4.88e-04 |
sarcomas_liposarcoma_up | Top 20 positive significant genes associated with liposarcomas, versus other soft-tissue tumors. | 14 | 0.03 | 2 | 57.79 | 5.45e-04 |
et743_blockstsa | Normally induced by the HDACi TSA, but induction is blocked by Et-743 | 15 | 0.04 | 2 | 53.94 | 6.28e-04 |
fsh_rat_granulosa_up | Up-regulated by FSH in immortalized rat granulosa cells (rFSH-17) | 15 | 0.04 | 2 | 53.94 | 6.28e-04 |
uvb_nhek3_all | Regulated by UV-B light in normal human epidermal keratinocytes | 751 | 1.86 | 8 | 4.31 | 6.70e-04 |
uvc_high_d8_dn | Progressively down-regulated through 18 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d8) | 70 | 0.17 | 3 | 17.34 | 7.31e-04 |
bay_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 606 | 1.50 | 7 | 4.67 | 9.00e-04 |
ageing_brain_up | Age-upregulated in the human frontal cortex | 446 | 1.10 | 6 | 5.44 | 9.57e-04 |
tsa_panc50_up | 50 "most interesting" genes upregulated by TSA treatment in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells | 77 | 0.19 | 3 | 15.76 | 9.64e-04 |
hdaci_colon_tsabut_up | Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 79 | 0.20 | 3 | 15.36 | 1.04e-03 |
hypoxia_reg_up | Upregulated by hypoxia in renal cells, and downregulated with reoxygenation | 80 | 0.20 | 3 | 15.17 | 1.08e-03 |
hdaci_colon_but2hrs_up | Upregulated by butyrate at 2 hrs in SW260 colon carcinoma cells | 87 | 0.22 | 3 | 13.95 | 1.37e-03 |
reovirus_hek293_up | Up-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney | 491 | 1.21 | 6 | 4.94 | 1.56e-03 |
dex_keratinocyte_1hr_dn | Down-regulated in primary human keratinocytes at 1 hour following treatment with 0.1 microM dexamethasone | 24 | 0.06 | 2 | 33.71 | 1.63e-03 |
tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 3.27 | 10 | 3.06 | 2.00e-03 |
ifna_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following treatment with interferon-alpha | 103 | 0.25 | 3 | 11.78 | 2.22e-03 |
cmv-uv_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus | 226 | 0.56 | 4 | 7.16 | 2.56e-03 |
adipogenesis_hmsc_class1_up | Up-regulated 1 day following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class I) | 31 | 0.08 | 2 | 26.10 | 2.71e-03 |
hdaci_colon_but_up | Upregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 233 | 0.58 | 4 | 6.94 | 2.85e-03 |
heartfailure_ventricles_dn | Downregulated in the ventricles of failing hearts (DCM and ICM) compared to healthy controls | 120 | 0.30 | 3 | 10.11 | 3.42e-03 |
hdaci_colon_tsa_up | Upregulated by TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 122 | 0.30 | 3 | 9.95 | 3.58e-03 |
caries_pulp_up | Up-regulated in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth | 410 | 1.01 | 5 | 4.93 | 3.81e-03 |
cmvuv-cmv_common_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with either human cytomegalovirus (CMV) or UV-inactivated CMV | 37 | 0.09 | 2 | 21.87 | 3.84e-03 |
nab_lung_up | Up-regulated in human non-small cell lung carcinoma cell line H460 following 24-hour treatment with sodium butyrate | 38 | 0.09 | 2 | 21.29 | 4.05e-03 |
uvb_nhek3_c8 | Regulated by UV-B light in normal human epidermal keratinocytes, cluster 8 | 132 | 0.33 | 3 | 9.19 | 4.46e-03 |
xpb_ttd-cs_dn | Down-regulated in XPB/TTD fibroblasts (expressing XPB-A355C), compared to XPB/CS fibroblasts (expressing XPB-T296C) | 41 | 0.10 | 2 | 19.73 | 4.70e-03 |
il1_cornea_up | Upregulated in corneal fibroblasts after interleukin-1 treatment (Tables 1 and 2) | 136 | 0.34 | 3 | 8.92 | 4.85e-03 |
scw_joint_24hrs_up | Up-regulated in rat ankle joints 24 hrs following intra-articular injection of Streptococcal cell wall (SCW), a rat model of arthritis. | 143 | 0.35 | 3 | 8.49 | 5.57e-03 |
ifna_uv-cmv_common_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following either infection with UV-inactivated CMV or interferon-alpha | 47 | 0.12 | 2 | 17.21 | 6.14e-03 |
genotoxins_all_24hrs_reg | Genes most consistently regulated in mouse lymphocytes (TK 3.7.2C) at 24 hours by all six genotoxins tested (cisplatin, methyl methanesulfonate, mitomycin C, taxol, hydroxyurea and etoposide) | 49 | 0.12 | 2 | 16.51 | 6.65e-03 |
hypoxia_review | Genes known to be induced by hypoxia | 160 | 0.40 | 3 | 7.59 | 7.58e-03 |
scw_joint_react_up | Up-regulated in rat ankle joints 16 days after intra-articular injection of Streptococcal cell wall (SCW), and 3 days after systemic injection of SCW to reactivate joint inflammation. | 166 | 0.41 | 3 | 7.31 | 8.38e-03 |
nf90_up | Upregulated by ectopic expression of NF90 in GHOST(3)CXCR4 cells | 56 | 0.14 | 2 | 14.45 | 8.61e-03 |
dac_bladder_up | Upregulated by DAC treatment in T24 bladder carcinoma cells | 60 | 0.15 | 2 | 13.48 | 9.83e-03 |