L2L L2L Microarray Analysis Tool

Results for G03A.profile.d50

Results summary View all lists in L2L MDB View all genes in G03A.profile.d50
List Name Description Total
scchn_hpvneg_dn Down-regulated in HPV-negative squamous cell carcinomas of the head and neck (SCCHN) vs. normal oral epithelium. 47 0.12 3 25.82 2.26e-04
heatshock_hela_4hr_dn Down-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 1829 4.52 14 3.10 2.58e-04
calres_mouse_dn Downregulated in the gastrocnemius muscle of aged (30-month) mice subjected to caloric restriction since young adulthood vs. age-matched controls 79 0.20 3 15.36 1.04e-03
hpv_high-risk_up Up-regulated in both HPV16- and HPV18-positive cervical tumors compared to normal cervial tissue. 21 0.05 2 38.53 1.24e-03
bap_mcf7_dn Down-regulated at least 1.4-fold following treatment of MCF-7 human breast carcinoma cells with carcinogen benzo(a)pyrene (BaP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. 135 0.33 3 8.99 4.75e-03
5fu_resist_gastric_up Upregulated in gastric cancer cell lines reistant to 5-fluorouracil, compared to parent chemosensitive lines 42 0.10 2 19.26 4.93e-03
ageing_brain_up Age-upregulated in the human frontal cortex 446 1.10 5 4.54 5.41e-03
genotoxins_all_4hrs_reg Genes regulated in mouse lymphocytes (TK 3.7.2C) at 4 hours by all six genotoxins tested (cisplatin, methyl methanesulfonate, mitomycin C, taxol, hydroxyurea and etoposide) 45 0.11 2 17.98 5.64e-03
idx_tsa_dn_cluster6 Strongly down-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 6) 48 0.12 2 16.86 6.39e-03
prmt5_kd_up Up-regulated by stable RNAi knock-down of PRMT5 in NIH 3T3 cells 306 0.76 4 5.29 7.41e-03

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