L2L L2L Microarray Analysis Tool

Results for D11A.profile.d50

Results summary View all lists in L2L MDB View all genes in D11A.profile.d50
List Name Description Total
probes
Expected
matches
Actual
matches
Fold
Enrichment
Binomial
p-value
human_tissue_testis Genes expressed specifically in human testis tissue 122 0.30 4 13.26 2.60e-04
dox_resist_gastric_up Upregulated in gastric cancer cell lines reistant to doxorubicin, compared to parent chemosensitive lines 74 0.18 3 16.40 8.59e-04
stress_genotoxic_specific_dn Genes down-regulated 4 hours following genotoxic stress that discriminate genotoxic from non-genotoxic stress 74 0.18 3 16.40 8.59e-04
p21_p53_any_dn Down-regulated at any timepoint (4-24 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent 77 0.19 3 15.76 9.64e-04
brca1_overexp_up Upregulated by induction of exogenous BRCA1 in EcR-293 cells 328 0.81 5 6.17 1.46e-03
middleage_dn Downregulated in fibroblasts from middle-age individuals, compared to young 23 0.06 2 35.18 1.49e-03
p21_p53_middle_dn Down-regulated at intermediate timepoints (12-16 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent 37 0.09 2 21.87 3.84e-03
dnmt1_ko_dn Downregulated following conditional knock-out of DNMT1 in MEFs 38 0.09 2 21.29 4.05e-03
caries_pulp_dn Down-regulated in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth 131 0.32 3 9.26 4.37e-03
genotoxins_all_4hrs_reg Genes regulated in mouse lymphocytes (TK 3.7.2C) at 4 hours by all six genotoxins tested (cisplatin, methyl methanesulfonate, mitomycin C, taxol, hydroxyurea and etoposide) 45 0.11 2 17.98 5.64e-03
hg_progeria_dn Downregulated in fibroblasts from patients with Hutchinson-Gilford progeria, compared to normal young individuals 48 0.12 2 16.86 6.39e-03
idx_tsa_dn_cluster6 Strongly down-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 6) 48 0.12 2 16.86 6.39e-03
senescence_hff_dn Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). 299 0.74 4 5.41 6.85e-03
adip_vs_preadip_up Upregulated in mature murine adipocytes (7 day differentiation) vs. preadipocytes (6 hr differentiation) 57 0.14 2 14.19 8.91e-03
jnk_dn Downregulated by expression of constitutively active JNK in 3T3 cells 57 0.14 2 14.19 8.91e-03
senescence_rep-ind_dn Down-regulated in models of both replicative (high-passge human foreskin fibroblast) and induced (repression of E7 in HeLa) cellular senescence. 171 0.42 3 7.10 9.09e-03
pod1_ko_up Up-regulated in glomeruli isolated from Pod1 knockout mice, versus wild-type controls 508 1.26 5 3.98 9.19e-03
adip_vs_fibro_up Upregulated following 7-day differentiation of murine 3T3-L1 fibroblasts into adipocytes 59 0.15 2 13.71 9.52e-03

Raw data (tab-delimited .txt)