Results summary | View all lists in L2L MDB | View all genes in D09A.profile.u50 |
List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
---|---|---|---|---|---|---|
alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 17 | 11.60 | 3.88e-13 |
alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 17 | 11.60 | 3.88e-13 |
alk5_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 0.86 | 12 | 13.99 | 1.27e-10 |
alk5_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 0.86 | 12 | 13.99 | 1.27e-10 |
et743_blockstsa | Normally induced by the HDACi TSA, but induction is blocked by Et-743 | 15 | 0.04 | 5 | 134.85 | 2.72e-10 |
caries_pulp_up | Up-regulated in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth | 410 | 1.01 | 10 | 9.87 | 1.15e-07 |
as3_hek293_up | Upregulated in HEK293 cells by treatment with arsenite | 19 | 0.05 | 4 | 85.17 | 1.40e-07 |
fsh_human_granulosa_up | Up-regulated by FSH in primary human granulosa cells (rFSH-17) | 31 | 0.08 | 4 | 52.20 | 1.11e-06 |
uvc_high_all_up | Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) | 34 | 0.08 | 4 | 47.59 | 1.63e-06 |
tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 3.27 | 15 | 4.59 | 1.78e-06 |
hdaci_colon_cluster1 | Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 1) | 12 | 0.03 | 3 | 101.14 | 3.27e-06 |
bay_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 606 | 1.50 | 10 | 6.68 | 3.84e-06 |
idx_tsa_up_cluster1 | Strongly up-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 1) | 44 | 0.11 | 4 | 36.78 | 4.68e-06 |
p53_brca1_up | Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 | 49 | 0.12 | 4 | 33.02 | 7.24e-06 |
et743_sarcoma_24hrs_up | Up-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 16 | 0.04 | 3 | 75.85 | 8.26e-06 |
uvc_xpcs_8hr_up | Up-regulated at 8 hours following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC | 108 | 0.27 | 5 | 18.73 | 8.33e-06 |
uvc_xpcs_all_up | Up-regulated at any timepoint following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC | 112 | 0.28 | 5 | 18.06 | 9.94e-06 |
brca1_overexp_prostate_up | Up-regulated with stable, ectopic overexpression of BRCA1 in DU-145 human prostate cancer cell lines, compared to neo-only controls | 308 | 0.76 | 7 | 9.19 | 1.44e-05 |
hdaci_colon_tsa2hrs_up | Upregulated by TSA at 2 hrs in SW260 colon carcinoma cells | 61 | 0.15 | 4 | 26.53 | 1.74e-05 |
hdaci_colon_tsa12hrs_up | Upregulated by TSA at 12 hrs in SW260 colon carcinoma cells | 21 | 0.05 | 3 | 57.79 | 1.94e-05 |
dsrna_up | Upregulated by dsRNA (polyI:C) in IFN-null GRE cells | 68 | 0.17 | 4 | 23.80 | 2.68e-05 |
hdaci_colon_tsabut_up | Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 79 | 0.20 | 4 | 20.48 | 4.84e-05 |
hypoxia_normal_up | Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) | 376 | 0.93 | 7 | 7.53 | 5.08e-05 |
hypoxia_review | Genes known to be induced by hypoxia | 160 | 0.40 | 5 | 12.64 | 5.51e-05 |
adipogenesis_hmsc_class1_up | Up-regulated 1 day following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class I) | 31 | 0.08 | 3 | 39.15 | 6.45e-05 |
hdaci_colon_but2hrs_up | Upregulated by butyrate at 2 hrs in SW260 colon carcinoma cells | 87 | 0.22 | 4 | 18.60 | 7.06e-05 |
tpa_sens_early_up | Upregulated by TPA at two consecutive timepoints between 15min-3hrs in sensitive HL-60 cells | 97 | 0.24 | 4 | 16.68 | 1.08e-04 |
nab_lung_up | Up-regulated in human non-small cell lung carcinoma cell line H460 following 24-hour treatment with sodium butyrate | 38 | 0.09 | 3 | 31.94 | 1.19e-04 |
vegf_hmmec_12hrs_up | Up-regulated at 12hrs follwing VEGF treatment of human myometrial microvascular endothelial cells | 38 | 0.09 | 3 | 31.94 | 1.19e-04 |
hdaci_three_up | Upregulated in several cell lines by all of TSA, SAHA, and MS-275 | 8 | 0.02 | 2 | 101.14 | 1.69e-04 |
aged_mouse_neocortex_up | Upregulated in the neocortex of aged adult mice (30-month) vs. young adult (5-month) | 111 | 0.27 | 4 | 14.58 | 1.81e-04 |
oxstress_breastca_up | Upregulated by H2O2, Menadione and t-BH in breast cancer cells | 45 | 0.11 | 3 | 26.97 | 1.98e-04 |
bay_pbmc_6hr_up | Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 1.17 | 7 | 5.96 | 2.14e-04 |
hdaci_colon_but16hrs_up | Upregulated by butyrate at 16 hrs in SW260 colon carcinoma cells | 47 | 0.12 | 3 | 25.82 | 2.26e-04 |
hdaci_colon_tsa_up | Upregulated by TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 122 | 0.30 | 4 | 13.26 | 2.60e-04 |
il2_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 510 | 1.26 | 7 | 5.55 | 3.28e-04 |
hdaci_colon_but12hrs_up | Upregulated by butyrate at 12 hrs in SW260 colon carcinoma cells | 54 | 0.13 | 3 | 22.47 | 3.41e-04 |
oldonly_fibro_up | Upregulated in fibroblasts from old (but not Werner) individuals, compared to young | 54 | 0.13 | 3 | 22.47 | 3.41e-04 |
et743_sarcoma_6hrs_up | Up-regulated at 6 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 56 | 0.14 | 3 | 21.67 | 3.80e-04 |
pgj2_up | Upregulated by treatment with the prostaglandin 15d-PGJ2 | 12 | 0.03 | 2 | 67.42 | 3.97e-04 |
csb_robust_up | Up-regulated robustly by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (9 of 9 pairwise comparisons). | 140 | 0.35 | 4 | 11.56 | 4.38e-04 |
hdaci_colon_sul48hrs_up | Upregulated by sulindac at 48 hrs in SW260 colon carcinoma cells | 140 | 0.35 | 4 | 11.56 | 4.38e-04 |
oldonly_fibro_dn | Downregulated in fibroblasts from old (but not Werner) individuals, compared to young | 61 | 0.15 | 3 | 19.90 | 4.88e-04 |
elongina_ko_up | Upregulated in MES cells from elongin-A knockout mice | 263 | 0.65 | 5 | 7.69 | 5.49e-04 |
stress_arsenic_specific_up | Genes up-regulated 4 hours following arsenic treatment that discriminate arsenic from other stress agents | 266 | 0.66 | 5 | 7.60 | 5.78e-04 |
fsh_rat_granulosa_up | Up-regulated by FSH in immortalized rat granulosa cells (rFSH-17) | 15 | 0.04 | 2 | 53.94 | 6.28e-04 |
uvc_high_d8_dn | Progressively down-regulated through 18 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d8) | 70 | 0.17 | 3 | 17.34 | 7.31e-04 |
senescence_hff_up | Up-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). | 284 | 0.70 | 5 | 7.12 | 7.75e-04 |
heat_glioblastoma_up | Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). | 78 | 0.19 | 3 | 15.56 | 1.00e-03 |
hypoxia_reg_up | Upregulated by hypoxia in renal cells, and downregulated with reoxygenation | 80 | 0.20 | 3 | 15.17 | 1.08e-03 |
lvad_heartfailure_up | Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device | 180 | 0.44 | 4 | 8.99 | 1.12e-03 |
uvc_high_all_dn | Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9) | 634 | 1.57 | 7 | 4.47 | 1.16e-03 |
old_fibro_up | Upregulated in fibroblasts from old individuals, compared to young | 84 | 0.21 | 3 | 14.45 | 1.24e-03 |
bay_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 1.17 | 6 | 5.11 | 1.32e-03 |
uvb_nhek3_c7 | Regulated by UV-B light in normal human epidermal keratinocytes, cluster 7 | 86 | 0.21 | 3 | 14.11 | 1.33e-03 |
dac_panc_up | Upregulated by DAC treatment in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells | 654 | 1.62 | 7 | 4.33 | 1.39e-03 |
hdaci_colon_sul_up | Upregulated by sulindac at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 192 | 0.47 | 4 | 8.43 | 1.42e-03 |
vegf_hmmec_6hrs_up | Up-regulated at 6hrs follwing VEGF treatment of human myometrial microvascular endothelial cells | 88 | 0.22 | 3 | 13.79 | 1.42e-03 |
emt_dn | Down-regulated during the TGFbeta-induced epithelial-to-mesenchymal transition (EMT) of Ras-transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late-stage tumor progression and metastasis) | 89 | 0.22 | 3 | 13.64 | 1.46e-03 |
bay_pbmc_24hr_up | Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 202 | 0.50 | 4 | 8.01 | 1.70e-03 |
hdaci_colon_but24hrs_up | Upregulated by butyrate at 24 hrs in SW260 colon carcinoma cells | 95 | 0.23 | 3 | 12.77 | 1.76e-03 |
il2_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 511 | 1.26 | 6 | 4.75 | 1.90e-03 |
esr_fibroblast_up | Up-regulated in the environmental stress response in human fibroblasts (regulated similarly by gamma and UV rediation and 4-NQO) | 98 | 0.24 | 3 | 12.38 | 1.93e-03 |
csb_reliable_up | Up-regulated reliably by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (7 of 9 pairwise comparisons). | 513 | 1.27 | 6 | 4.73 | 1.94e-03 |
vegf_hmmec_3hrs_up | Up-regulated at 3hrs follwing VEGF treatment of human myometrial microvascular endothelial cells | 99 | 0.24 | 3 | 12.26 | 1.98e-03 |
hbx_nl_dn | Downregulated by expression of Hepatitis B virus HBx protein in normal hepatocytes (Hhep) (Fig. 3B+C) | 27 | 0.07 | 2 | 29.97 | 2.06e-03 |
hdaci_colon_sul24hrs_up | Upregulated by sulindac at 24 hrs in SW260 colon carcinoma cells | 102 | 0.25 | 3 | 11.90 | 2.16e-03 |
preadip_vs_fibro_up | Upregulated following 6hr differentiation of murine 3T3-L1 fibroblasts into preadipocytes; presumed direct transcriptional targets of differentiation cocktail of insulin, dexamethasone and isobutyl-methylxanthine | 29 | 0.07 | 2 | 27.90 | 2.37e-03 |
et743_sarcoma_72hrs_up | Up-regulated at48 hours following treatment with Et-743 in at least 6 of 8 sarcoma cell lines | 106 | 0.26 | 3 | 11.45 | 2.41e-03 |
5fu_resist_gastric_dn | Downregulated in gastric cancer cell lines reistant to 5-fluorouracil, compared to parent chemosensitive lines | 30 | 0.07 | 2 | 26.97 | 2.54e-03 |
et743_sarcoma_up | Up-regulated following treatment with Et-743 at any timepoint in at least 8 of 11 sarcoma cell lines | 111 | 0.27 | 3 | 10.93 | 2.75e-03 |
htert_dn | Downregulated in hTERT-immortalized fibroblasts vs. non-immortalized controls | 112 | 0.28 | 3 | 10.84 | 2.82e-03 |
hdaci_colon_but_up | Upregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 233 | 0.58 | 4 | 6.94 | 2.85e-03 |
bleo_human_lymph_high_4hrs_up | Up-regulated at 4 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin | 32 | 0.08 | 2 | 25.28 | 2.88e-03 |
tpa_sens_middle_up | Upregulated by TPA at two consecutive timepoints between 2-24hrs in sensitive HL-60 cells | 114 | 0.28 | 3 | 10.65 | 2.96e-03 |
uvb_nhek3_all | Regulated by UV-B light in normal human epidermal keratinocytes | 751 | 1.86 | 7 | 3.77 | 2.99e-03 |
dixoin_pbmnc_dn | Down-regulated in peripheral blood mononuclear cells of subjects with high exposure to dioxin, compared to low-exposure controls. | 117 | 0.29 | 3 | 10.37 | 3.18e-03 |
tgfb_mammary_up | Up-regulated in normal mouse mammary gland cells following treatment with TGF-beta (top 124 genes). | 118 | 0.29 | 3 | 10.28 | 3.26e-03 |
ros_mouse_aorta_dn | Down-regulated in mouse aorta by chronic treatment with PPARgamma agonist rosiglitazone | 127 | 0.31 | 3 | 9.56 | 4.01e-03 |
hdaci_colon_sul12hrs_up | Upregulated by sulindac at 12 hrs in SW260 colon carcinoma cells | 40 | 0.10 | 2 | 20.23 | 4.48e-03 |
bay_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 268 | 0.66 | 4 | 6.04 | 4.68e-03 |
hdaci_colon_but48hrs_up | Upregulated by butyrate at 48 hrs in SW260 colon carcinoma cells | 135 | 0.33 | 3 | 8.99 | 4.75e-03 |
pubertal_mammary | Differentially expressed (> 2-fold) in the developing mouse mammary gland at any time point between 3- and 7-weeks of age. | 1260 | 3.11 | 9 | 2.89 | 4.77e-03 |
o6bg_resist_medulloblastoma_up | Up-regulated in a medulloblastoma cell line resistant to both BCNU and O6-BG, compared to sensitive parent line (D-341 MED) | 46 | 0.11 | 2 | 17.59 | 5.88e-03 |
il2_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 646 | 1.60 | 6 | 3.76 | 5.91e-03 |
vegf_hmmec_all_up | Up-regulated at any timepoint follwing VEGF treatment of human myometrial microvascular endothelial cells | 147 | 0.36 | 3 | 8.26 | 6.01e-03 |
17aag_ovca_up | Up-regulated 24 hours following treatment of human ovarian cancer cells (A2780) with the HSP90 inhibitor 17AAG (60 nM) | 53 | 0.13 | 2 | 15.27 | 7.74e-03 |