L2L L2L Microarray Analysis Tool

Results for D09A.profile.u50

Results summary View all lists in L2L MDB View all genes in D09A.profile.u50
List Name Description Total
probes
Expected
matches
Actual
matches
Fold
Enrichment
Binomial
p-value
alk1_hmvec_2hr_up Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 593 1.47 17 11.60 3.88e-13
alk1_hmvec_4hr_up Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 593 1.47 17 11.60 3.88e-13
alk5_hmvec_2hr_up Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 347 0.86 12 13.99 1.27e-10
alk5_hmvec_4hr_up Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 347 0.86 12 13.99 1.27e-10
et743_blockstsa Normally induced by the HDACi TSA, but induction is blocked by Et-743 15 0.04 5 134.85 2.72e-10
caries_pulp_up Up-regulated in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth 410 1.01 10 9.87 1.15e-07
as3_hek293_up Upregulated in HEK293 cells by treatment with arsenite 19 0.05 4 85.17 1.40e-07
fsh_human_granulosa_up Up-regulated by FSH in primary human granulosa cells (rFSH-17) 31 0.08 4 52.20 1.11e-06
uvc_high_all_up Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) 34 0.08 4 47.59 1.63e-06
tgfb_hmvec_4hr_dn Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. 1321 3.27 15 4.59 1.78e-06
hdaci_colon_cluster1 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 1) 12 0.03 3 101.14 3.27e-06
bay_pbmc_2hr_up Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 606 1.50 10 6.68 3.84e-06
idx_tsa_up_cluster1 Strongly up-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 1) 44 0.11 4 36.78 4.68e-06
p53_brca1_up Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 49 0.12 4 33.02 7.24e-06
et743_sarcoma_24hrs_up Up-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines 16 0.04 3 75.85 8.26e-06
uvc_xpcs_8hr_up Up-regulated at 8 hours following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC 108 0.27 5 18.73 8.33e-06
uvc_xpcs_all_up Up-regulated at any timepoint following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC 112 0.28 5 18.06 9.94e-06
brca1_overexp_prostate_up Up-regulated with stable, ectopic overexpression of BRCA1 in DU-145 human prostate cancer cell lines, compared to neo-only controls 308 0.76 7 9.19 1.44e-05
hdaci_colon_tsa2hrs_up Upregulated by TSA at 2 hrs in SW260 colon carcinoma cells 61 0.15 4 26.53 1.74e-05
hdaci_colon_tsa12hrs_up Upregulated by TSA at 12 hrs in SW260 colon carcinoma cells 21 0.05 3 57.79 1.94e-05
dsrna_up Upregulated by dsRNA (polyI:C) in IFN-null GRE cells 68 0.17 4 23.80 2.68e-05
hdaci_colon_tsabut_up Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 79 0.20 4 20.48 4.84e-05
hypoxia_normal_up Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) 376 0.93 7 7.53 5.08e-05
hypoxia_review Genes known to be induced by hypoxia 160 0.40 5 12.64 5.51e-05
adipogenesis_hmsc_class1_up Up-regulated 1 day following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class I) 31 0.08 3 39.15 6.45e-05
hdaci_colon_but2hrs_up Upregulated by butyrate at 2 hrs in SW260 colon carcinoma cells 87 0.22 4 18.60 7.06e-05
tpa_sens_early_up Upregulated by TPA at two consecutive timepoints between 15min-3hrs in sensitive HL-60 cells 97 0.24 4 16.68 1.08e-04
nab_lung_up Up-regulated in human non-small cell lung carcinoma cell line H460 following 24-hour treatment with sodium butyrate 38 0.09 3 31.94 1.19e-04
vegf_hmmec_12hrs_up Up-regulated at 12hrs follwing VEGF treatment of human myometrial microvascular endothelial cells 38 0.09 3 31.94 1.19e-04
hdaci_three_up Upregulated in several cell lines by all of TSA, SAHA, and MS-275 8 0.02 2 101.14 1.69e-04
aged_mouse_neocortex_up Upregulated in the neocortex of aged adult mice (30-month) vs. young adult (5-month) 111 0.27 4 14.58 1.81e-04
oxstress_breastca_up Upregulated by H2O2, Menadione and t-BH in breast cancer cells 45 0.11 3 26.97 1.98e-04
bay_pbmc_6hr_up Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 475 1.17 7 5.96 2.14e-04
hdaci_colon_but16hrs_up Upregulated by butyrate at 16 hrs in SW260 colon carcinoma cells 47 0.12 3 25.82 2.26e-04
hdaci_colon_tsa_up Upregulated by TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 122 0.30 4 13.26 2.60e-04
il2_pbmc_4hr_up Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 510 1.26 7 5.55 3.28e-04
hdaci_colon_but12hrs_up Upregulated by butyrate at 12 hrs in SW260 colon carcinoma cells 54 0.13 3 22.47 3.41e-04
oldonly_fibro_up Upregulated in fibroblasts from old (but not Werner) individuals, compared to young 54 0.13 3 22.47 3.41e-04
et743_sarcoma_6hrs_up Up-regulated at 6 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines 56 0.14 3 21.67 3.80e-04
pgj2_up Upregulated by treatment with the prostaglandin 15d-PGJ2 12 0.03 2 67.42 3.97e-04
csb_robust_up Up-regulated robustly by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (9 of 9 pairwise comparisons). 140 0.35 4 11.56 4.38e-04
hdaci_colon_sul48hrs_up Upregulated by sulindac at 48 hrs in SW260 colon carcinoma cells 140 0.35 4 11.56 4.38e-04
oldonly_fibro_dn Downregulated in fibroblasts from old (but not Werner) individuals, compared to young 61 0.15 3 19.90 4.88e-04
elongina_ko_up Upregulated in MES cells from elongin-A knockout mice 263 0.65 5 7.69 5.49e-04
stress_arsenic_specific_up Genes up-regulated 4 hours following arsenic treatment that discriminate arsenic from other stress agents 266 0.66 5 7.60 5.78e-04
fsh_rat_granulosa_up Up-regulated by FSH in immortalized rat granulosa cells (rFSH-17) 15 0.04 2 53.94 6.28e-04
uvc_high_d8_dn Progressively down-regulated through 18 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d8) 70 0.17 3 17.34 7.31e-04
senescence_hff_up Up-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). 284 0.70 5 7.12 7.75e-04
heat_glioblastoma_up Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). 78 0.19 3 15.56 1.00e-03
hypoxia_reg_up Upregulated by hypoxia in renal cells, and downregulated with reoxygenation 80 0.20 3 15.17 1.08e-03
lvad_heartfailure_up Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device 180 0.44 4 8.99 1.12e-03
uvc_high_all_dn Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9) 634 1.57 7 4.47 1.16e-03
old_fibro_up Upregulated in fibroblasts from old individuals, compared to young 84 0.21 3 14.45 1.24e-03
bay_pbmc_48hr_up Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 475 1.17 6 5.11 1.32e-03
uvb_nhek3_c7 Regulated by UV-B light in normal human epidermal keratinocytes, cluster 7 86 0.21 3 14.11 1.33e-03
dac_panc_up Upregulated by DAC treatment in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells 654 1.62 7 4.33 1.39e-03
hdaci_colon_sul_up Upregulated by sulindac at any timepoint up to 48 hrs in SW260 colon carcinoma cells 192 0.47 4 8.43 1.42e-03
vegf_hmmec_6hrs_up Up-regulated at 6hrs follwing VEGF treatment of human myometrial microvascular endothelial cells 88 0.22 3 13.79 1.42e-03
emt_dn Down-regulated during the TGFbeta-induced epithelial-to-mesenchymal transition (EMT) of Ras-transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late-stage tumor progression and metastasis) 89 0.22 3 13.64 1.46e-03
bay_pbmc_24hr_up Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 202 0.50 4 8.01 1.70e-03
hdaci_colon_but24hrs_up Upregulated by butyrate at 24 hrs in SW260 colon carcinoma cells 95 0.23 3 12.77 1.76e-03
il2_pbmc_48hr_up Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 511 1.26 6 4.75 1.90e-03
esr_fibroblast_up Up-regulated in the environmental stress response in human fibroblasts (regulated similarly by gamma and UV rediation and 4-NQO) 98 0.24 3 12.38 1.93e-03
csb_reliable_up Up-regulated reliably by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (7 of 9 pairwise comparisons). 513 1.27 6 4.73 1.94e-03
vegf_hmmec_3hrs_up Up-regulated at 3hrs follwing VEGF treatment of human myometrial microvascular endothelial cells 99 0.24 3 12.26 1.98e-03
hbx_nl_dn Downregulated by expression of Hepatitis B virus HBx protein in normal hepatocytes (Hhep) (Fig. 3B+C) 27 0.07 2 29.97 2.06e-03
hdaci_colon_sul24hrs_up Upregulated by sulindac at 24 hrs in SW260 colon carcinoma cells 102 0.25 3 11.90 2.16e-03
preadip_vs_fibro_up Upregulated following 6hr differentiation of murine 3T3-L1 fibroblasts into preadipocytes; presumed direct transcriptional targets of differentiation cocktail of insulin, dexamethasone and isobutyl-methylxanthine 29 0.07 2 27.90 2.37e-03
et743_sarcoma_72hrs_up Up-regulated at48 hours following treatment with Et-743 in at least 6 of 8 sarcoma cell lines 106 0.26 3 11.45 2.41e-03
5fu_resist_gastric_dn Downregulated in gastric cancer cell lines reistant to 5-fluorouracil, compared to parent chemosensitive lines 30 0.07 2 26.97 2.54e-03
et743_sarcoma_up Up-regulated following treatment with Et-743 at any timepoint in at least 8 of 11 sarcoma cell lines 111 0.27 3 10.93 2.75e-03
htert_dn Downregulated in hTERT-immortalized fibroblasts vs. non-immortalized controls 112 0.28 3 10.84 2.82e-03
hdaci_colon_but_up Upregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells 233 0.58 4 6.94 2.85e-03
bleo_human_lymph_high_4hrs_up Up-regulated at 4 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin 32 0.08 2 25.28 2.88e-03
tpa_sens_middle_up Upregulated by TPA at two consecutive timepoints between 2-24hrs in sensitive HL-60 cells 114 0.28 3 10.65 2.96e-03
uvb_nhek3_all Regulated by UV-B light in normal human epidermal keratinocytes 751 1.86 7 3.77 2.99e-03
dixoin_pbmnc_dn Down-regulated in peripheral blood mononuclear cells of subjects with high exposure to dioxin, compared to low-exposure controls. 117 0.29 3 10.37 3.18e-03
tgfb_mammary_up Up-regulated in normal mouse mammary gland cells following treatment with TGF-beta (top 124 genes). 118 0.29 3 10.28 3.26e-03
ros_mouse_aorta_dn Down-regulated in mouse aorta by chronic treatment with PPARgamma agonist rosiglitazone 127 0.31 3 9.56 4.01e-03
hdaci_colon_sul12hrs_up Upregulated by sulindac at 12 hrs in SW260 colon carcinoma cells 40 0.10 2 20.23 4.48e-03
bay_pbmc_24hr_dn Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 268 0.66 4 6.04 4.68e-03
hdaci_colon_but48hrs_up Upregulated by butyrate at 48 hrs in SW260 colon carcinoma cells 135 0.33 3 8.99 4.75e-03
pubertal_mammary Differentially expressed (> 2-fold) in the developing mouse mammary gland at any time point between 3- and 7-weeks of age. 1260 3.11 9 2.89 4.77e-03
o6bg_resist_medulloblastoma_up Up-regulated in a medulloblastoma cell line resistant to both BCNU and O6-BG, compared to sensitive parent line (D-341 MED) 46 0.11 2 17.59 5.88e-03
il2_pbmc_24hr_dn Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 646 1.60 6 3.76 5.91e-03
vegf_hmmec_all_up Up-regulated at any timepoint follwing VEGF treatment of human myometrial microvascular endothelial cells 147 0.36 3 8.26 6.01e-03
17aag_ovca_up Up-regulated 24 hours following treatment of human ovarian cancer cells (A2780) with the HSP90 inhibitor 17AAG (60 nM) 53 0.13 2 15.27 7.74e-03

Raw data (tab-delimited .txt)