L2L L2L Microarray Analysis Tool

Results for D08A.profile.ud50

Results summary View all lists in L2L MDB View all genes in D08A.profile.ud50
List Name Description Total
probes
Expected
matches
Actual
matches
Fold
Enrichment
Binomial
p-value
alk1_hmvec_2hr_up Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 593 2.93 17 5.80 1.33e-08
alk1_hmvec_4hr_up Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 593 2.93 17 5.80 1.33e-08
as3_hek293_up Upregulated in HEK293 cells by treatment with arsenite 19 0.09 5 53.23 3.24e-08
bleo_human_lymph_high_4hrs_up Up-regulated at 4 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin 32 0.16 5 31.60 5.32e-07
hdaci_colon_but24hrs_up Upregulated by butyrate at 24 hrs in SW260 colon carcinoma cells 95 0.47 7 14.90 5.45e-07
et743_blockstsa Normally induced by the HDACi TSA, but induction is blocked by Et-743 15 0.07 4 53.94 7.81e-07
bay_pbmc_2hr_up Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 606 3.00 14 4.67 3.05e-06
hdaci_colon_but48hrs_up Upregulated by butyrate at 48 hrs in SW260 colon carcinoma cells 135 0.67 7 10.49 5.75e-06
stress_arsenic_specific_up Genes up-regulated 4 hours following arsenic treatment that discriminate arsenic from other stress agents 266 1.32 9 6.84 9.05e-06
bay_pbmc_24hr_up Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 202 1.00 8 8.01 9.12e-06
alk5_hmvec_2hr_up Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 347 1.72 10 5.83 1.18e-05
alk5_hmvec_4hr_up Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 347 1.72 10 5.83 1.18e-05
il2_pbmc_4hr_up Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 510 2.52 12 4.76 1.26e-05
adipogenesis_hmsc_class1_up Up-regulated 1 day following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class I) 31 0.15 4 26.10 1.69e-05
fsh_human_granulosa_up Up-regulated by FSH in primary human granulosa cells (rFSH-17) 31 0.15 4 26.10 1.69e-05
bay_pbmc_4hr_up Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 544 2.69 12 4.46 2.37e-05
uvc_high_all_up Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) 34 0.17 4 23.80 2.46e-05
hdaci_colon_but_up Upregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells 233 1.15 8 6.94 2.54e-05
hdaci_colon_cluster1 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 1) 12 0.06 3 50.57 2.57e-05
bay_pbmc_6hr_up Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 475 2.35 11 4.68 3.30e-05
heatshock_hela_2hr_up Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 177 0.88 7 8.00 3.32e-05
heat_glioblastoma_up Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). 78 0.39 5 12.97 4.62e-05
caries_pulp_up Up-regulated in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth 410 2.03 10 4.93 4.84e-05
hdaci_colon_but16hrs_up Upregulated by butyrate at 16 hrs in SW260 colon carcinoma cells 47 0.23 4 17.21 8.99e-05
idx_tsa_dn_cluster6 Strongly down-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 6) 48 0.24 4 16.86 9.77e-05
tgfb_hmvec_4hr_dn Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. 1321 6.53 18 2.76 1.53e-04
hdaci_colon_but12hrs_up Upregulated by butyrate at 12 hrs in SW260 colon carcinoma cells 54 0.27 4 14.98 1.55e-04
aged_mouse_neocortex_up Upregulated in the neocortex of aged adult mice (30-month) vs. young adult (5-month) 111 0.55 5 9.11 2.45e-04
insulin_adip_sens_dn Down-regulated by insulin in murine adipocytes, but response is blunted following induction of insulin-resistance with TNFalpha treatment 29 0.14 3 20.92 4.01e-04
p53genes_all p53 transcriptional targets 33 0.16 3 18.39 5.90e-04
senescence_hff_up Up-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). 284 1.40 7 4.99 6.04e-04
heatshock_hela_4hr_up Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 675 3.34 11 3.30 6.71e-04
hdaci_three_up Upregulated in several cell lines by all of TSA, SAHA, and MS-275 8 0.04 2 50.57 6.71e-04
bay_pbmc_48hr_up Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 475 2.35 9 3.83 7.11e-04
old_fibro_up Upregulated in fibroblasts from old individuals, compared to young 84 0.42 4 9.63 8.41e-04
uvb_nhek3_c7 Regulated by UV-B light in normal human epidermal keratinocytes, cluster 7 86 0.43 4 9.41 9.19e-04
il2_pbmc_48hr_up Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 511 2.53 9 3.56 1.18e-03
csb_reliable_up Up-regulated reliably by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (7 of 9 pairwise comparisons). 513 2.54 9 3.55 1.21e-03
irs1_ko_adip_up Up-regulated in brown preadipocytes from Irs1-knockout mice, which display severe defects in adipocyte differentiation, versus wild-type controls 159 0.79 5 6.36 1.25e-03
oxstress_breastca_up Upregulated by H2O2, Menadione and t-BH in breast cancer cells 45 0.22 3 13.48 1.47e-03
scw_joint_react_up Up-regulated in rat ankle joints 16 days after intra-articular injection of Streptococcal cell wall (SCW), and 3 days after systemic injection of SCW to reactivate joint inflammation. 166 0.82 5 6.09 1.51e-03
il2_pbmc_6hr_up Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 530 2.62 9 3.43 1.51e-03
pgj2_up Upregulated by treatment with the prostaglandin 15d-PGJ2 12 0.06 2 33.71 1.56e-03
il2_pbmc_24hr_dn Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 646 3.19 10 3.13 1.68e-03
dac_panc_up Upregulated by DAC treatment in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells 654 3.23 10 3.09 1.84e-03
et743pt650_colonca_up Upregulated by both Et-743 and Pt-650 in HCT116 cells (Fig. 6D) 13 0.06 2 31.12 1.84e-03
p53_brca1_up Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 49 0.24 3 12.38 1.88e-03
cis_xpc_dn Reduced expression in XPC-defective fibroblasts, compared to normal fibroblasts, following treatment with cisplatin 363 1.79 7 3.90 2.45e-03
fsh_rat_granulosa_up Up-regulated by FSH in immortalized rat granulosa cells (rFSH-17) 15 0.07 2 26.97 2.46e-03
et743_sarcoma_24hrs_up Up-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines 16 0.08 2 25.28 2.80e-03
bleo_human_lymph_high_24hrs_up Up-regulated at 24 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin 197 0.97 5 5.13 3.17e-03
hdaci_colon_tsa2hrs_up Upregulated by TSA at 2 hrs in SW260 colon carcinoma cells 61 0.30 3 9.95 3.51e-03
oldonly_fibro_dn Downregulated in fibroblasts from old (but not Werner) individuals, compared to young 61 0.30 3 9.95 3.51e-03
adip_diff_cluster5 Strongly upregulated at 24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 5) 67 0.33 3 9.06 4.57e-03
stress_genotoxic_specific_up Genes up-regulated 4 hours following genotoxic stress that discriminate genotoxic from non-genotoxic stress 67 0.33 3 9.06 4.57e-03
hdaci_colon_tsa12hrs_up Upregulated by TSA at 12 hrs in SW260 colon carcinoma cells 21 0.10 2 19.26 4.82e-03
uvb_nhek3_all Regulated by UV-B light in normal human epidermal keratinocytes 751 3.71 10 2.69 4.85e-03
csb_robust_up Up-regulated robustly by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (9 of 9 pairwise comparisons). 140 0.69 4 5.78 5.38e-03
dox_resist_gastric_up Upregulated in gastric cancer cell lines reistant to doxorubicin, compared to parent chemosensitive lines 74 0.37 3 8.20 6.03e-03
scw_joint_4hrs_up Up-regulated in rat ankle joints 4 hrs following intra-articular injection of Streptococcal cell wall (SCW), a rat model of arthritis. 230 1.14 5 4.40 6.07e-03
p21_p53_any_dn Down-regulated at any timepoint (4-24 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent 77 0.38 3 7.88 6.73e-03
hdaci_colon_cluster9 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 9, associated with histone hyperAc) 78 0.39 3 7.78 6.98e-03
calres_mouse_dn Downregulated in the gastrocnemius muscle of aged (30-month) mice subjected to caloric restriction since young adulthood vs. age-matched controls 79 0.39 3 7.68 7.22e-03
hdaci_colon_tsabut_up Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 79 0.39 3 7.68 7.22e-03
werner_fibro_up Upregulated in fibroblasts from individuals with Werner syndrome, compared to normal, young individuals 81 0.40 3 7.49 7.74e-03
hbx_nl_dn Downregulated by expression of Hepatitis B virus HBx protein in normal hepatocytes (Hhep) (Fig. 3B+C) 27 0.13 2 14.98 7.90e-03
cmv_hcmv_timecourse_24hrs_dn Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 24 hours 82 0.41 3 7.40 8.00e-03
bap_hepg2_up Up-regulated at least 1.4-fold following treatment of HepG2 human hepatocellular carcinoma cells with carcinogen benzo(a)pyrene (BaP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. 83 0.41 3 7.31 8.27e-03
uvb_nhek1_c2 Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 2 28 0.14 2 14.45 8.48e-03
preadip_vs_fibro_up Upregulated following 6hr differentiation of murine 3T3-L1 fibroblasts into preadipocytes; presumed direct transcriptional targets of differentiation cocktail of insulin, dexamethasone and isobutyl-methylxanthine 29 0.14 2 13.95 9.08e-03
hdaci_colon_but2hrs_up Upregulated by butyrate at 2 hrs in SW260 colon carcinoma cells 87 0.43 3 6.97 9.41e-03
5fu_resist_gastric_dn Downregulated in gastric cancer cell lines reistant to 5-fluorouracil, compared to parent chemosensitive lines 30 0.15 2 13.48 9.70e-03
oldwerner_fibro_up Commonly upregulated in fibroblasts from Werner Syndrome and old individuals, compared to young 30 0.15 2 13.48 9.70e-03
uv_unique_fibro_up Up-regulated at any timepoint by treatment of human fibroblasts with UV light, but not bygamma radiation or 4-NQO 30 0.15 2 13.48 9.70e-03

Raw data (tab-delimited .txt)