L2L L2L Microarray Analysis Tool

Results for D08A.profile.u50

Results summary View all lists in L2L MDB View all genes in D08A.profile.u50
List Name Description Total
probes
Expected
matches
Actual
matches
Fold
Enrichment
Binomial
p-value
alk1_hmvec_2hr_up Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 593 1.47 14 9.55 5.48e-10
alk1_hmvec_4hr_up Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 593 1.47 14 9.55 5.48e-10
as3_hek293_up Upregulated in HEK293 cells by treatment with arsenite 19 0.05 5 106.46 1.04e-09
hdaci_colon_but24hrs_up Upregulated by butyrate at 24 hrs in SW260 colon carcinoma cells 95 0.23 7 29.81 5.15e-09
bay_pbmc_2hr_up Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 606 1.50 13 8.68 6.94e-09
il2_pbmc_4hr_up Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 510 1.26 12 9.52 9.51e-09
bleo_human_lymph_high_4hrs_up Up-regulated at 4 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin 32 0.08 5 63.21 1.76e-08
bay_pbmc_4hr_up Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 544 1.34 12 8.92 1.93e-08
bay_pbmc_6hr_up Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 475 1.17 11 9.37 4.57e-08
et743_blockstsa Normally induced by the HDACi TSA, but induction is blocked by Et-743 15 0.04 4 107.88 4.99e-08
bay_pbmc_24hr_up Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 202 0.50 8 16.02 5.44e-08
hdaci_colon_but48hrs_up Upregulated by butyrate at 48 hrs in SW260 colon carcinoma cells 135 0.33 7 20.98 5.92e-08
caries_pulp_up Up-regulated in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth 410 1.01 10 9.87 1.15e-07
hdaci_colon_but_up Upregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells 233 0.58 8 13.89 1.62e-07
alk5_hmvec_2hr_up Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 347 0.86 9 10.49 2.95e-07
alk5_hmvec_4hr_up Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 347 0.86 9 10.49 2.95e-07
stress_arsenic_specific_up Genes up-regulated 4 hours following arsenic treatment that discriminate arsenic from other stress agents 266 0.66 8 12.17 4.43e-07
adipogenesis_hmsc_class1_up Up-regulated 1 day following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class I) 31 0.08 4 52.20 1.11e-06
fsh_human_granulosa_up Up-regulated by FSH in primary human granulosa cells (rFSH-17) 31 0.08 4 52.20 1.11e-06
uvc_high_all_up Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) 34 0.08 4 47.59 1.63e-06
heat_glioblastoma_up Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). 78 0.19 5 25.93 1.68e-06
hdaci_colon_cluster1 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 1) 12 0.03 3 101.14 3.27e-06
hdaci_colon_but16hrs_up Upregulated by butyrate at 16 hrs in SW260 colon carcinoma cells 47 0.12 4 34.43 6.12e-06
heatshock_hela_2hr_up Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 177 0.44 6 13.71 6.23e-06
il2_pbmc_48hr_up Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 511 1.26 9 7.12 6.92e-06
dac_panc_up Upregulated by DAC treatment in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells 654 1.62 10 6.19 7.43e-06
il2_pbmc_6hr_up Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 530 1.31 9 6.87 9.24e-06
hdaci_colon_but12hrs_up Upregulated by butyrate at 12 hrs in SW260 colon carcinoma cells 54 0.13 4 29.97 1.07e-05
bay_pbmc_48hr_up Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 475 1.17 8 6.81 3.04e-05
cis_xpc_dn Reduced expression in XPC-defective fibroblasts, compared to normal fibroblasts, following treatment with cisplatin 363 0.90 7 7.80 4.08e-05
il2_pbmc_24hr_dn Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 646 1.60 9 5.64 4.30e-05
heatshock_hela_4hr_up Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 675 1.67 9 5.39 6.01e-05
p53genes_all p53 transcriptional targets 33 0.08 3 36.78 7.80e-05
senescence_hff_up Up-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). 284 0.70 6 8.55 8.78e-05
bleo_human_lymph_high_24hrs_up Up-regulated at 24 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin 197 0.49 5 10.27 1.46e-04
tgfb_hmvec_4hr_dn Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. 1321 3.27 12 3.67 1.51e-04
hdaci_three_up Upregulated in several cell lines by all of TSA, SAHA, and MS-275 8 0.02 2 101.14 1.69e-04
aged_mouse_neocortex_up Upregulated in the neocortex of aged adult mice (30-month) vs. young adult (5-month) 111 0.27 4 14.58 1.81e-04
oxstress_breastca_up Upregulated by H2O2, Menadione and t-BH in breast cancer cells 45 0.11 3 26.97 1.98e-04
idx_tsa_dn_cluster6 Strongly down-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 6) 48 0.12 3 25.28 2.40e-04
p53_brca1_up Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 49 0.12 3 24.77 2.56e-04
pgj2_up Upregulated by treatment with the prostaglandin 15d-PGJ2 12 0.03 2 67.42 3.97e-04
csb_robust_up Up-regulated robustly by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (9 of 9 pairwise comparisons). 140 0.35 4 11.56 4.38e-04
et743pt650_colonca_up Upregulated by both Et-743 and Pt-650 in HCT116 cells (Fig. 6D) 13 0.03 2 62.24 4.68e-04
hdaci_colon_tsa2hrs_up Upregulated by TSA at 2 hrs in SW260 colon carcinoma cells 61 0.15 3 19.90 4.88e-04
oldonly_fibro_dn Downregulated in fibroblasts from old (but not Werner) individuals, compared to young 61 0.15 3 19.90 4.88e-04
fsh_rat_granulosa_up Up-regulated by FSH in immortalized rat granulosa cells (rFSH-17) 15 0.04 2 53.94 6.28e-04
stress_genotoxic_specific_up Genes up-regulated 4 hours following genotoxic stress that discriminate genotoxic from non-genotoxic stress 67 0.17 3 18.11 6.43e-04
uvb_nhek3_all Regulated by UV-B light in normal human epidermal keratinocytes 751 1.86 8 4.31 6.70e-04
et743_sarcoma_24hrs_up Up-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines 16 0.04 2 50.57 7.17e-04
scw_joint_react_up Up-regulated in rat ankle joints 16 days after intra-articular injection of Streptococcal cell wall (SCW), and 3 days after systemic injection of SCW to reactivate joint inflammation. 166 0.41 4 9.75 8.28e-04
ageing_brain_up Age-upregulated in the human frontal cortex 446 1.10 6 5.44 9.57e-04
hdaci_colon_cluster9 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 9, associated with histone hyperAc) 78 0.19 3 15.56 1.00e-03
calres_mouse_dn Downregulated in the gastrocnemius muscle of aged (30-month) mice subjected to caloric restriction since young adulthood vs. age-matched controls 79 0.20 3 15.36 1.04e-03
hdaci_colon_tsabut_up Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 79 0.20 3 15.36 1.04e-03
lvad_heartfailure_up Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device 180 0.44 4 8.99 1.12e-03
cmv_hcmv_timecourse_24hrs_dn Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 24 hours 82 0.20 3 14.80 1.16e-03
hdaci_colon_tsa12hrs_up Upregulated by TSA at 12 hrs in SW260 colon carcinoma cells 21 0.05 2 38.53 1.24e-03
uvb_nhek3_c7 Regulated by UV-B light in normal human epidermal keratinocytes, cluster 7 86 0.21 3 14.11 1.33e-03
hdaci_colon_but2hrs_up Upregulated by butyrate at 2 hrs in SW260 colon carcinoma cells 87 0.22 3 13.95 1.37e-03
emt_dn Down-regulated during the TGFbeta-induced epithelial-to-mesenchymal transition (EMT) of Ras-transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late-stage tumor progression and metastasis) 89 0.22 3 13.64 1.46e-03
adip_diff_cluster1 Progressively downregulated over 24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 1) 96 0.24 3 12.64 1.82e-03
esr_fibroblast_up Up-regulated in the environmental stress response in human fibroblasts (regulated similarly by gamma and UV rediation and 4-NQO) 98 0.24 3 12.38 1.93e-03
csb_reliable_up Up-regulated reliably by stable expression of wt CSB in hTERT-immortalized CS1AN CSB-null fibroblasts vs. eGFP-expressing controls (7 of 9 pairwise comparisons). 513 1.27 6 4.73 1.94e-03
et743_hela_up Upregulated by Et-743 in HeLa cells 99 0.24 3 12.26 1.98e-03
hbx_nl_dn Downregulated by expression of Hepatitis B virus HBx protein in normal hepatocytes (Hhep) (Fig. 3B+C) 27 0.07 2 29.97 2.06e-03
cmv_all_dn Downregulated at any timepoint following infection of primary human foreskin fibroblasts with CMV 213 0.53 4 7.60 2.07e-03
ribavirin_rsv_dn Up-regulation by infection of human pulmonary epithelian cells (A549) with respiratory syncytial virus (RSV) is inhibited by the anti-viral drug ribavirin 101 0.25 3 12.02 2.10e-03
uvb_nhek1_c2 Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 2 28 0.07 2 28.90 2.21e-03
baf57_bt549_up Up-regulated following stable re-expression of BAF57 in Bt549 breast cancer cells that lack functional BAF57 364 0.90 5 5.56 2.30e-03
emt_up Up-regulated during the TGFbeta-induced epithelial-to-mesenchymal transition (EMT) of Ras-transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late-stage tumor progression and metastasis) 105 0.26 3 11.56 2.35e-03
insulin_adip_sens_dn Down-regulated by insulin in murine adipocytes, but response is blunted following induction of insulin-resistance with TNFalpha treatment 29 0.07 2 27.90 2.37e-03
preadip_vs_fibro_up Upregulated following 6hr differentiation of murine 3T3-L1 fibroblasts into preadipocytes; presumed direct transcriptional targets of differentiation cocktail of insulin, dexamethasone and isobutyl-methylxanthine 29 0.07 2 27.90 2.37e-03
5fu_resist_gastric_dn Downregulated in gastric cancer cell lines reistant to 5-fluorouracil, compared to parent chemosensitive lines 30 0.07 2 26.97 2.54e-03
uv_unique_fibro_up Up-regulated at any timepoint by treatment of human fibroblasts with UV light, but not bygamma radiation or 4-NQO 30 0.07 2 26.97 2.54e-03
uvc_xpcs_8hr_up Up-regulated at 8 hours following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC 108 0.27 3 11.24 2.54e-03
scw_joint_4hrs_up Up-regulated in rat ankle joints 4 hrs following intra-articular injection of Streptococcal cell wall (SCW), a rat model of arthritis. 230 0.57 4 7.04 2.72e-03
uvc_xpcs_all_up Up-regulated at any timepoint following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC 112 0.28 3 10.84 2.82e-03
uvc_low_all_up Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m^2) (clusters a1-a4) 33 0.08 2 24.52 3.07e-03
hdaci_colon_tsa_up Upregulated by TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 122 0.30 3 9.95 3.58e-03
cmvuv-cmv_common_hcmv_6hrs_up Up-regulated in fibroblasts at 6 hours following infection with either human cytomegalovirus (CMV) or UV-inactivated CMV 37 0.09 2 21.87 3.84e-03
nab_lung_up Up-regulated in human non-small cell lung carcinoma cell line H460 following 24-hour treatment with sodium butyrate 38 0.09 2 21.29 4.05e-03
vegf_hmmec_12hrs_up Up-regulated at 12hrs follwing VEGF treatment of human myometrial microvascular endothelial cells 38 0.09 2 21.29 4.05e-03
elongina_ko_up Upregulated in MES cells from elongin-A knockout mice 263 0.65 4 6.15 4.38e-03
hdaci_colon_sul12hrs_up Upregulated by sulindac at 12 hrs in SW260 colon carcinoma cells 40 0.10 2 20.23 4.48e-03
diab_neph_dn Downregulated in the glomeruli of cadaver kidneys from patients with diabetic nephropathy, compared to normal controls 829 2.05 7 3.42 5.09e-03
cmv_24hrs_dn Downregulated at 24hrs following infection of primary human foreskin fibroblasts with CMV 140 0.35 3 8.67 5.25e-03
hdaci_colon_sul48hrs_up Upregulated by sulindac at 48 hrs in SW260 colon carcinoma cells 140 0.35 3 8.67 5.25e-03
idx_tsa_up_cluster1 Strongly up-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 1) 44 0.11 2 18.39 5.40e-03
tpa_sens_late_dn Downregulated by TPA at two consecutive timepoints between 12-48 hrs in sensitive HL-60 cells 451 1.11 5 4.48 5.67e-03
cmv_hcmv_6hrs_up Up-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus (CMV) 46 0.11 2 17.59 5.88e-03
o6bg_resist_medulloblastoma_up Up-regulated in a medulloblastoma cell line resistant to both BCNU and O6-BG, compared to sensitive parent line (D-341 MED) 46 0.11 2 17.59 5.88e-03
genotoxins_all_24hrs_reg Genes most consistently regulated in mouse lymphocytes (TK 3.7.2C) at 24 hours by all six genotoxins tested (cisplatin, methyl methanesulfonate, mitomycin C, taxol, hydroxyurea and etoposide) 49 0.12 2 16.51 6.65e-03
aged_mouse_muscle_up Upregulated in the gastrocnemius muscle of aged adult mice (30-month) vs. young adult (5-month) 51 0.13 2 15.86 7.19e-03
hypoxia_review Genes known to be induced by hypoxia 160 0.40 3 7.59 7.58e-03
reovirus_hek293_up Up-regulated at any timepoint up to 24 hours following infection of HEK293 cells with reovirus strain T3Abney 491 1.21 5 4.12 8.02e-03
oldonly_fibro_up Upregulated in fibroblasts from old (but not Werner) individuals, compared to young 54 0.13 2 14.98 8.03e-03
vegf_huvec_2hrs_up Up-regulated 2 hours after VEGF treatment in human umbilical vein endothelial cells 54 0.13 2 14.98 8.03e-03
et743_sarcoma_6hrs_up Up-regulated at 6 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines 56 0.14 2 14.45 8.61e-03

Raw data (tab-delimited .txt)