L2L L2L Microarray Analysis Tool

Results for D07X.profile.u50

Results summary View all lists in L2L MDB View all genes in D07X.profile.u50
List Name Description Total
probes
Expected
matches
Actual
matches
Fold
Enrichment
Binomial
p-value
lvad_heartfailure_up Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device 180 0.44 22 49.44 2.94e-30
as3_hek293_up Upregulated in HEK293 cells by treatment with arsenite 19 0.05 6 127.75 6.02e-12
dex_keratinocyte_1hr_dn Down-regulated in primary human keratinocytes at 1 hour following treatment with 0.1 microM dexamethasone 24 0.06 6 101.14 2.96e-11
adipogenesis_hmsc_class1_up Up-regulated 1 day following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class I) 31 0.08 6 78.30 1.59e-10
idx_tsa_up_cluster1 Strongly up-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 1) 44 0.11 5 45.97 9.25e-08
dex_keratinocyte_4hr_dn Down-regulated in primary human keratinocytes at 4 hours following treatment with 0.1 microM dexamethasone 69 0.17 5 29.31 9.09e-07
uvb_nhek3_c7 Regulated by UV-B light in normal human epidermal keratinocytes, cluster 7 86 0.21 5 23.52 2.72e-06
adipogenesis_hmsc_class2_up Up-regulated 1-14 days following the differentiation of human bone marrow mesenchymal stem cells (hMSC) into adipocytes, versus untreated hMSC cells (Class II) 15 0.04 3 80.91 6.72e-06
heatshock_hela_4hr_up Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 675 1.67 10 5.99 9.75e-06
ni2_mouse_up Upregulated by nickel(II) in sensitive A/J mouse lung tissue 65 0.16 4 24.89 2.24e-05
scw_joint_4hrs_up Up-regulated in rat ankle joints 4 hrs following intra-articular injection of Streptococcal cell wall (SCW), a rat model of arthritis. 230 0.57 6 10.55 2.74e-05
hdaci_colon_but_up Upregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells 233 0.58 6 10.42 2.94e-05
scw_joint_24hrs_up Up-regulated in rat ankle joints 24 hrs following intra-articular injection of Streptococcal cell wall (SCW), a rat model of arthritis. 143 0.35 5 14.14 3.23e-05
tgfb_hmvec_2hr_dn Down-regulated 2 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. 353 0.87 7 8.02 3.42e-05
fsh_human_granulosa_up Up-regulated by FSH in primary human granulosa cells (rFSH-17) 31 0.08 3 39.15 6.45e-05
aged_mouse_retina_any_up Up-regulated in the retina of 16-month aged mice from any of four strains (S8, S10, SR1, B6J), versus 3-month young controls 36 0.09 3 33.71 1.01e-04
ageing_brain_up Age-upregulated in the human frontal cortex 446 1.10 7 6.35 1.46e-04
tgfb_hmvec_4hr_dn Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. 1321 3.27 12 3.67 1.51e-04
bay_pbmc_48hr_dn Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 318 0.79 6 7.63 1.62e-04
bay_pbmc_2hr_up Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 606 1.50 8 5.34 1.63e-04
alk5_hmvec_2hr_dn Down-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 202 0.50 5 10.01 1.64e-04
alk5_hmvec_4hr_dn Down-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 202 0.50 5 10.01 1.64e-04
hdaci_three_up Upregulated in several cell lines by all of TSA, SAHA, and MS-275 8 0.02 2 101.14 1.69e-04
oxstress_breastca_up Upregulated by H2O2, Menadione and t-BH in breast cancer cells 45 0.11 3 26.97 1.98e-04
o6bg_resist_medulloblastoma_up Up-regulated in a medulloblastoma cell line resistant to both BCNU and O6-BG, compared to sensitive parent line (D-341 MED) 46 0.11 3 26.38 2.12e-04
hdaci_colon_cluster2 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 2) 9 0.02 2 89.90 2.17e-04
uvc_high_all_dn Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9) 634 1.57 8 5.10 2.21e-04
senescence_hela_up Up-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. 262 0.65 5 7.72 5.40e-04
tnfa_nfkb_ind_up Up-regulated at any timepoint following TNFa treatment, independent of NFkB function 14 0.03 2 57.79 5.45e-04
stress_arsenic_specific_up Genes up-regulated 4 hours following arsenic treatment that discriminate arsenic from other stress agents 266 0.66 5 7.60 5.78e-04
caries_pulp_up Up-regulated in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth 410 1.01 6 5.92 6.21e-04
et743_blockstsa Normally induced by the HDACi TSA, but induction is blocked by Et-743 15 0.04 2 53.94 6.28e-04
fsh_rat_granulosa_up Up-regulated by FSH in immortalized rat granulosa cells (rFSH-17) 15 0.04 2 53.94 6.28e-04
uvb_nhek3_all Regulated by UV-B light in normal human epidermal keratinocytes 751 1.86 8 4.31 6.70e-04
tnfalpha_30min_up Upregulated 30min after TNF-alpha treatment of HeLa cells 68 0.17 3 17.85 6.71e-04
uvc_high_d8_dn Progressively down-regulated through 18 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d8) 70 0.17 3 17.34 7.31e-04
scw_joint_react_up Up-regulated in rat ankle joints 16 days after intra-articular injection of Streptococcal cell wall (SCW), and 3 days after systemic injection of SCW to reactivate joint inflammation. 166 0.41 4 9.75 8.28e-04
tsa_panc50_up 50 "most interesting" genes upregulated by TSA treatment in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells 77 0.19 3 15.76 9.64e-04
hdaci_colon_tsabut_up Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 79 0.20 3 15.36 1.04e-03
hypoxia_reg_up Upregulated by hypoxia in renal cells, and downregulated with reoxygenation 80 0.20 3 15.17 1.08e-03
alzheimers_disease_up Upregulated in correlation with overt Alzheimer's Disease, in the CA1 region of the hippocampus 3137 7.75 18 2.32 1.12e-03
uvb_nhek1_c4 Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 4 20 0.05 2 40.45 1.13e-03
hdaci_colon_but2hrs_up Upregulated by butyrate at 2 hrs in SW260 colon carcinoma cells 87 0.22 3 13.95 1.37e-03
il2_pbmc_24hr_up Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 503 1.24 6 4.83 1.76e-03
brcax_a_up Up-regulated in one group (A) of BRCAx tumors (familial non-BRCA1/BRCA2 breast cancer), compared to a second BRCAx group (B) 30 0.07 2 26.97 2.54e-03
cmv_hcmv_6hrs_dn Down-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus (CMV) 109 0.27 3 11.13 2.61e-03
uvc_high_d1_dn Down-regulated at 6 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d1) 31 0.08 2 26.10 2.71e-03
fsh_ovary_mcv152_dn Down-regulated in ovarian epithelial cells (MCV152) 72 hours following FSH treatment, compared to untreated 111 0.27 3 10.93 2.75e-03
cocaine_brain_4wks_up Up-regulated in the nucleus accumbens of mice after 4 weeks of cocaine treatment 112 0.28 3 10.84 2.82e-03
5azac_hepg2_up Up-regulated in human hepatoma cells (HepG2) following 48 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC). 1630 4.03 11 2.73 2.96e-03
ageing_kidney_dn Down-regulation is associated with increasing age in normal human kidney tissue from 74 patients 238 0.59 4 6.80 3.08e-03
heartfailure_ventricles_dn Downregulated in the ventricles of failing hearts (DCM and ICM) compared to healthy controls 120 0.30 3 10.11 3.42e-03
ageing_kidney_specific_dn Down-regulation is associated with increasing age in normal human kidney tissue from 74 patients, and expression is higher in kidney than in whole blood 248 0.61 4 6.52 3.56e-03
hdaci_colon_tsa_up Upregulated by TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 122 0.30 3 9.95 3.58e-03
tnfalpha_all_up Upregulated at any timepoint after TNF-alpha treatment of HeLa cells 122 0.30 3 9.95 3.58e-03
caries_pulp_dn Down-regulated in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth 131 0.32 3 9.26 4.37e-03
bay_pbmc_24hr_dn Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 268 0.66 4 6.04 4.68e-03
bap_mcf7_dn Down-regulated at least 1.4-fold following treatment of MCF-7 human breast carcinoma cells with carcinogen benzo(a)pyrene (BaP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. 135 0.33 3 8.99 4.75e-03
hdaci_colon_but48hrs_up Upregulated by butyrate at 48 hrs in SW260 colon carcinoma cells 135 0.33 3 8.99 4.75e-03
diab_neph_dn Downregulated in the glomeruli of cadaver kidneys from patients with diabetic nephropathy, compared to normal controls 829 2.05 7 3.42 5.09e-03
cmv_hcmv_timecourse_all_dn Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) 839 2.07 7 3.38 5.42e-03
tpa_sens_late_dn Downregulated by TPA at two consecutive timepoints between 12-48 hrs in sensitive HL-60 cells 451 1.11 5 4.48 5.67e-03
hdaci_colon_but16hrs_up Upregulated by butyrate at 16 hrs in SW260 colon carcinoma cells 47 0.12 2 17.21 6.14e-03
hsc_intermediateprogenitors_shared Up-regulated in mouse hematopoietic intermediate progenitors from both adult bone marrow and fetal liver (Cluster v, Intermediate Progenitors Shared) 151 0.37 3 8.04 6.47e-03
hematop_stem_all_up Up-regulated in populations of human hematopoietic stem cells (CD34+/CD38-/Lin-) from bone marrow, umbilical cord blood, and peripheral blood stem-progenitor cells, compared to the stem cell-depleted population (CD34+/[CD38/Lin++]) 52 0.13 2 15.56 7.46e-03
hsc_intermediateprogenitors_adult Up-regulated in mouse hematopoietic intermediate progenitors from adult bone marrow (Intermediate Progenitors Shared + Adult) 161 0.40 3 7.54 7.71e-03
cmv_uv-cmv_common_hcmv_6hrs_dn Down-regulated in fibroblasts at 6 hours following infection with either human cytomegalovirus (CMV) or UV-inactivated CMV 54 0.13 2 14.98 8.03e-03
hdaci_colon_but12hrs_up Upregulated by butyrate at 12 hrs in SW260 colon carcinoma cells 54 0.13 2 14.98 8.03e-03
hsc_intermediateprogenitors_fetal Up-regulated in mouse hematopoietic intermediate progenitors from fetal liver (Intermediate Progenitors Shared + Fetal) 167 0.41 3 7.27 8.52e-03
lh_granulosa_up Up-regulated in human granulosa cells stimulated with luteinizing hormone (LH) 167 0.41 3 7.27 8.52e-03
zmpste24_ko_up Fifty genes most strongly up-regulated in liver tissue from mice deficient in the lamin-protease Zmpste24/Face1, versus wild-type controls 57 0.14 2 14.19 8.91e-03
gh_ghrhr_ko_6hrs_dn Down-regulated at least 2-fold 6 hours following injection of human growth hormone (GH) into mice lacking functional GHRHR (lit/lit), and with no detectable endogenous GH 58 0.14 2 13.95 9.21e-03
il2_pbmc_4hr_up Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 510 1.26 5 3.97 9.34e-03
heatshock_hela_2hr_up Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 177 0.44 3 6.86 9.97e-03

Raw data (tab-delimited .txt)