L2L L2L Microarray Analysis Tool

Results for D07A.profile.d50

Results summary View all lists in L2L MDB View all genes in D07A.profile.d50
List Name Description Total
probes
Expected
matches
Actual
matches
Fold
Enrichment
Binomial
p-value
il2_pbmc_24hr_dn Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 646 1.60 15 9.39 1.69e-10
uvc_low_a2_up Up-regulated at 6-12 hours following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m^2) (cluster a2) 17 0.04 5 118.98 5.57e-10
bay_pbmc_48hr_up Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 475 1.17 12 10.22 4.34e-09
uvc_low_all_up Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m^2) (clusters a1-a4) 33 0.08 5 61.29 2.07e-08
baf57_bt549_dn Down-regulated following stable re-expression of BAF57 in Bt549 breast cancer cells that lack functional BAF57 554 1.37 12 8.76 2.35e-08
aom-dss_colon_5wks_up Up-regulated in mouse colonic mucosa after 5 weeks of treatment with the colon carcinogens azoxymethane (AOM) and 2% dextran sodium sulfate (DSS) vs. untreated controls. 133 0.33 7 21.29 5.34e-08
ribavirin_rsv_dn Up-regulation by infection of human pulmonary epithelian cells (A549) with respiratory syncytial virus (RSV) is inhibited by the anti-viral drug ribavirin 101 0.25 6 24.03 2.36e-07
alk5_hmvec_2hr_up Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 347 0.86 9 10.49 2.95e-07
alk5_hmvec_4hr_up Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 347 0.86 9 10.49 2.95e-07
xpb_ttd-cs_up Up-regulated in XPB/TTD fibroblasts (expressing XPB-A355C), compared to XPB/CS fibroblasts (expressing XPB-T296C) 57 0.14 5 35.49 3.47e-07
idx_tsa_dn_cluster3 Strongly down-regulated at 8-96 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 3) 108 0.27 6 22.47 3.52e-07
bay_pbmc_6hr_up Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 475 1.17 10 8.52 4.40e-07
bleo_human_lymph_high_24hrs_up Up-regulated at 24 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin 197 0.49 7 14.37 7.68e-07
il2_pbmc_4hr_up Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 510 1.26 10 7.93 8.35e-07
tzd_adip_dn Downregulated by treatment of mature murine adipocytes with the PPARgamma agonist troglitazone 29 0.07 4 55.80 8.44e-07
il2_pbmc_48hr_up Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 511 1.26 10 7.92 8.50e-07
pubertal_mammary Differentially expressed (> 2-fold) in the developing mouse mammary gland at any time point between 3- and 7-weeks of age. 1260 3.11 15 4.82 1.00e-06
bleo_mouse_lymph_high_24hrs_dn Down-regulated at 24 hours following treatment of mouse lymphocytes (TK 3.7.2C) with a high dose of bleomycin 71 0.18 5 28.49 1.05e-06
il2_pbmc_6hr_up Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 530 1.31 10 7.63 1.18e-06
cmv_all_dn Downregulated at any timepoint following infection of primary human foreskin fibroblasts with CMV 213 0.53 7 13.29 1.29e-06
tgfb_hmvec_4hr_dn Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. 1321 3.27 15 4.59 1.78e-06
cmv_hcmv_timecourse_all_dn Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) 839 2.07 12 5.79 1.87e-06
microrna_mammal Predicted MicroRNA targets conserved across human, mouse and rat 1331 3.29 15 4.56 1.95e-06
caries_pulp_up Up-regulated in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth 410 1.01 8 7.89 1.07e-05
cmv-uv_hcmv_6hrs_dn Down-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus 207 0.51 6 11.73 1.52e-05
microrna_vertebrate Predicted MicroRNA targets conserved across human, mouse, rat, zebrafish and fugu 214 0.53 6 11.34 1.83e-05
jnk_up Upregulated by expression of constitutively active JNK in 3T3 cells 66 0.16 4 24.52 2.38e-05
bay_pbmc_2hr_up Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 606 1.50 9 6.01 2.63e-05
cmv_24hrs_dn Downregulated at 24hrs following infection of primary human foreskin fibroblasts with CMV 140 0.35 5 14.45 2.92e-05
pod1_ko_up Up-regulated in glomeruli isolated from Pod1 knockout mice, versus wild-type controls 508 1.26 8 6.37 4.87e-05
adip_vs_preadip_dn Downregulated in mature murine adipocytes (7 day differentiation) vs. preadipocytes (6 hr differentiation) 84 0.21 4 19.26 6.15e-05
il6_fibro_up Upregulated following IL-6 treatment in normal skin fibroblasts 85 0.21 4 19.04 6.44e-05
caries_pulp_high_up Highly up-regulated (>4-fold) in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth 168 0.42 5 12.04 6.94e-05
bay_pbmc_4hr_up Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 544 1.34 8 5.95 7.82e-05
insulin_adip_insens_up Up-regulated by insulin in murine adipocytes, and continue to respond following induction of insulin-resistance with TNFalpha treatment 37 0.09 3 32.80 1.10e-04
pubertal_mammary_3-4wks_up Up-regulated > 1.5-fold in the developing mouse mammary gland between 3 and 4 weeks of age. 301 0.74 6 8.06 1.20e-04
prmt5_kd_up Up-regulated by stable RNAi knock-down of PRMT5 in NIH 3T3 cells 306 0.76 6 7.93 1.32e-04
zmpste24_ko_dn Fifty genes most strongly down-regulated in liver tissue from mice deficient in the lamin-protease Zmpste24/Face1, versus wild-type controls 42 0.10 3 28.90 1.61e-04
cmv_hcmv_6hrs_dn Down-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus (CMV) 109 0.27 4 14.85 1.69e-04
idx_tsa_up_cluster1 Strongly up-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 1) 44 0.11 3 27.58 1.85e-04
cancer_neoplastic_meta_up Sixty-seven genes commonly upregulated in cancer relative to normal tissue, from a meta-analysis of the OncoMine gene expression database 115 0.28 4 14.07 2.07e-04
inos_all_dn Downregulated following iNOS induction in hepatocytes (Tables 3-17) 117 0.29 4 13.83 2.22e-04
uvb_scc_dn Downregulated by UV-B light in squamous cell carinoma cells 219 0.54 5 9.24 2.39e-04
idx_tsa_dn_cluster6 Strongly down-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 6) 48 0.12 3 25.28 2.40e-04
hdaci_colon_cur2hrs_up Upregulated by curcumin at 2 hrs in SW260 colon carcinoma cells 49 0.12 3 24.77 2.56e-04
tgfb_hmvec_2hr_dn Down-regulated 2 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. 353 0.87 6 6.88 2.83e-04
pubertal_mammary_4-5wks_up Up-regulated > 1.5-fold in the developing mouse mammary gland between 4 and 5 weeks of age. 368 0.91 6 6.60 3.53e-04
il2_pbmc_48hr_dn Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. 531 1.31 7 5.33 4.16e-04
h2o2_csbdiff_c1 Stronger induction by H2O2 in CSB-null fibroblasts, compared to CSB-rescued (Table 2, cluster 1) 58 0.14 3 20.92 4.21e-04
uvc_ttd_8hr_dn Down-regulated at 8 hours following treatment of XPB/TTD fibroblasts with 3 J/m^2 UVC 382 0.94 6 6.35 4.29e-04
igf1_nih3t3_up Up-regulated by treatment with IGF1 of NIH3T3 cells overexpressing IGF1R (Tables 1+3) 61 0.15 3 19.90 4.88e-04
gh_exogenous_early_dn Down-regulated at early time points (1-4 hours) following treatment of mammary carcinoma cells (MCF-7) with exogenous human growth hormone 14 0.03 2 57.79 5.45e-04
adip_diff_cluster2 Strongly upregulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 2) 64 0.16 3 18.96 5.62e-04
uv_unique_fibro_dn Down-regulated at any timepoint by treatment of human fibroblasts with UV light, but not bygamma radiation or 4-NQO 66 0.16 3 18.39 6.15e-04
sarcomas_histiocytoma_up Top 20 positive significant genes associated with malignant fibrous histiocytomas, versus other soft-tissue tumors. 16 0.04 2 50.57 7.17e-04
sarcomas_synovial_up Top 20 positive significant genes associated with synovial sarcomas, versus other soft-tissue tumors. 16 0.04 2 50.57 7.17e-04
microrna_human Predicted human MicroRNA targets 2276 5.63 15 2.67 7.36e-04
uv-cmv_unique_hcmv_6hrs_dn Down-regulated in fibroblasts at 6 hours following infection with UV-inactivated CMV, but not untreated CMV 164 0.41 4 9.87 7.92e-04
stress_genotoxic_specific_dn Genes down-regulated 4 hours following genotoxic stress that discriminate genotoxic from non-genotoxic stress 74 0.18 3 16.40 8.59e-04
senescence_hff_dn Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). 299 0.74 5 6.76 9.75e-04
hdaci_colon_cur_up Upregulated by curcumin at any timepoint up to 48 hrs in SW260 colon carcinoma cells 174 0.43 4 9.30 9.86e-04
hdaci_colon_cluster9 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 9, associated with histone hyperAc) 78 0.19 3 15.56 1.00e-03
stress_tpa_specific_up Genes up-regulated 4 hours following TPA treatment that discriminate TPA from other stress agents 78 0.19 3 15.56 1.00e-03
calres_mouse_dn Downregulated in the gastrocnemius muscle of aged (30-month) mice subjected to caloric restriction since young adulthood vs. age-matched controls 79 0.20 3 15.36 1.04e-03
hdaci_colon_sul30min_dn Downregulated by sulindac at 30 min in SW260 colon carcinoma cells 79 0.20 3 15.36 1.04e-03
ifn_gamma_up Upregulated 2-fold in HT1080 cells 6 hours following treatment with interferon gamma 80 0.20 3 15.17 1.08e-03
arthritis_mouse_common_up Up-regulated in joint tissue from both severely arthritic HTLV-I transgenic mice and IL-1Ra knock-out mice, versus wild-type littermate controls. 459 1.13 6 5.29 1.11e-03
as3_fibro_c5 Downregulated moderately by sodium arsenite in fibroblasts (Cluster 5) 20 0.05 2 40.45 1.13e-03
cmv_hcmv_timecourse_24hrs_dn Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 24 hours 82 0.20 3 14.80 1.16e-03
gh_autocrine_dn Down-regulated following stable autocrine expression of human growth hormone in mammary carcinoma cells (MCF-7) 189 0.47 4 8.56 1.34e-03
dsrna_dn Downregulated by dsRNA (polyI:C) in IFN-null GRE cells 24 0.06 2 33.71 1.63e-03
vegf_huvec_up 20 genes with the largest fold-change up-regulation at any time point (30min to 24 hours) after VEGF treatment in human umbilical vein endothelial cells 24 0.06 2 33.71 1.63e-03
uvb_nhek1_up Upregulated by UV-B light in normal human epidermal keratinocytes 336 0.83 5 6.02 1.63e-03
bay_pbmc_24hr_up Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 202 0.50 4 8.01 1.70e-03
hdaci_colon_sul_dn Downregulated by sulindac at any timepoint up to 48 hrs in SW260 colon carcinoma cells 340 0.84 5 5.95 1.71e-03
hdaci_colon_but24hrs_up Upregulated by butyrate at 24 hrs in SW260 colon carcinoma cells 95 0.23 3 12.77 1.76e-03
htert_up Upregulated in hTERT-immortalized fibroblasts vs. non-immortalized controls 97 0.24 3 12.51 1.87e-03
uvb_nhek1_c2 Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 2 28 0.07 2 28.90 2.21e-03
brca1_overexp_dn Downregulated by induction of exogenous BRCA1 in EcR-293 cells 220 0.54 4 7.36 2.32e-03
emt_up Up-regulated during the TGFbeta-induced epithelial-to-mesenchymal transition (EMT) of Ras-transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late-stage tumor progression and metastasis) 105 0.26 3 11.56 2.35e-03
bleo_human_lymph_high_4hrs_up Up-regulated at 4 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin 32 0.08 2 25.28 2.88e-03
dnmt1_ko_up Upregulated following conditional knock-out of DNMT1 in MEFs 117 0.29 3 10.37 3.18e-03
brca_brca1_neg Genes whose expression is consistently negatively correlated with brca1 germline status in breast cancer - higher expression is associated with BRCA1 tumors 250 0.62 4 6.47 3.66e-03
cmv_hcmv_timecourse_24hrs_up Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 24 hours 123 0.30 3 9.87 3.66e-03
ros_mouse_aorta_dn Down-regulated in mouse aorta by chronic treatment with PPARgamma agonist rosiglitazone 127 0.31 3 9.56 4.01e-03
elongina_ko_up Upregulated in MES cells from elongin-A knockout mice 263 0.65 4 6.15 4.38e-03
avoidance_dn Down-regulated in hippocampi from the Syracuse high-avoidance (SHA) rat line, versus Syracuse low-avoidance (SLA) rat line. 40 0.10 2 20.23 4.48e-03
bap_mcf7_dn Down-regulated at least 1.4-fold following treatment of MCF-7 human breast carcinoma cells with carcinogen benzo(a)pyrene (BaP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. 135 0.33 3 8.99 4.75e-03
hdaci_colon_but48hrs_up Upregulated by butyrate at 48 hrs in SW260 colon carcinoma cells 135 0.33 3 8.99 4.75e-03
arthritis_mouse_il1ko_up Up-regulated in joint tissue from severely arthritic 13 week-old IL-1Ra knock-out mice, versus wild-type littermate controls. 271 0.67 4 5.97 4.87e-03
5fu_resist_gastric_up Upregulated in gastric cancer cell lines reistant to 5-fluorouracil, compared to parent chemosensitive lines 42 0.10 2 19.26 4.93e-03
cited1_ko_het_up Up-regulated in pubertal mammary glands from CITED1 knockout mice, which display disturbed mammary development, versus heterozygotes 43 0.11 2 18.82 5.16e-03
brca_er_neg Genes whose expression is consistently negatively correlated with estrogen receptor status in breast cancer - higher expression is associated with ER-negative tumors 1519 3.75 10 2.66 5.29e-03
uvc_high_all_dn Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9) 634 1.57 6 3.83 5.41e-03
ifn_beta_up Upregulated 2-fold in HT1080 cells 6 hours following treatment with interferon beta 143 0.35 3 8.49 5.57e-03
pubertal_mammary_5-6wks_up Up-regulated > 1.5-fold in the developing mouse mammary gland between 5 and 6 weeks of age. 143 0.35 3 8.49 5.57e-03
o6bg_resist_medulloblastoma_up Up-regulated in a medulloblastoma cell line resistant to both BCNU and O6-BG, compared to sensitive parent line (D-341 MED) 46 0.11 2 17.59 5.88e-03
dac_panc_up Upregulated by DAC treatment in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells 654 1.62 6 3.71 6.26e-03
heatshock_hela_4hr_dn Down-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 1829 4.52 11 2.43 6.82e-03
heatshock_hela_4hr_up Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 675 1.67 6 3.60 7.26e-03
bay_pbmc_6hr_dn Down-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. 483 1.19 5 4.19 7.50e-03
cmv_hcmv_timecourse_all_up Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) 895 2.21 7 3.16 7.60e-03
uvc_high_d9_dn Progressively down-regulated through 24 hrs following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d9) 53 0.13 2 15.27 7.74e-03
cmv_uv-cmv_common_hcmv_6hrs_dn Down-regulated in fibroblasts at 6 hours following infection with either human cytomegalovirus (CMV) or UV-inactivated CMV 54 0.13 2 14.98 8.03e-03
uvc_xpcs_8hr_dn Down-regulated at 8 hours following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC 911 2.25 7 3.11 8.32e-03
ifn_any_up Upregulated 2-fold in HT1080 cells 6 hours following treatment with any of interferons alpha, beta and gamma 172 0.43 3 7.06 9.23e-03
as3_fibro_dn Downregulated by sodium arsenite in fibroblasts (Clusters 4, 5, and 6) 59 0.15 2 13.71 9.52e-03
hsc_hscandprogenitors_fetal Up-regulated in mouse hematopoietic stem cells and progenitors from fetal liver (HSC and Progenitors Shared) 717 1.77 6 3.39 9.58e-03
hsc_hscandprogenitors_shared Up-regulated in mouse hematopoietic stem cells and progenitors from both adult bone marrow and fetal liver (Cluster iii, HSC and Progenitors Shared) 717 1.77 6 3.39 9.58e-03

Raw data (tab-delimited .txt)