L2L Microarray Analysis Tool
Results for D07A.profile.d50
| Results summary | View all lists in L2L MDB | View all genes in D07A.profile.d50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| il2_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 646 | 1.60 | 15 | 9.39 | 1.69e-10 |
| uvc_low_a2_up | Up-regulated at 6-12 hours following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m^2) (cluster a2) | 17 | 0.04 | 5 | 118.98 | 5.57e-10 |
| bay_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 1.17 | 12 | 10.22 | 4.34e-09 |
| uvc_low_all_up | Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a low dose (10 J/m^2) (clusters a1-a4) | 33 | 0.08 | 5 | 61.29 | 2.07e-08 |
| baf57_bt549_dn | Down-regulated following stable re-expression of BAF57 in Bt549 breast cancer cells that lack functional BAF57 | 554 | 1.37 | 12 | 8.76 | 2.35e-08 |
| aom-dss_colon_5wks_up | Up-regulated in mouse colonic mucosa after 5 weeks of treatment with the colon carcinogens azoxymethane (AOM) and 2% dextran sodium sulfate (DSS) vs. untreated controls. | 133 | 0.33 | 7 | 21.29 | 5.34e-08 |
| ribavirin_rsv_dn | Up-regulation by infection of human pulmonary epithelian cells (A549) with respiratory syncytial virus (RSV) is inhibited by the anti-viral drug ribavirin | 101 | 0.25 | 6 | 24.03 | 2.36e-07 |
| alk5_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 0.86 | 9 | 10.49 | 2.95e-07 |
| alk5_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 0.86 | 9 | 10.49 | 2.95e-07 |
| xpb_ttd-cs_up | Up-regulated in XPB/TTD fibroblasts (expressing XPB-A355C), compared to XPB/CS fibroblasts (expressing XPB-T296C) | 57 | 0.14 | 5 | 35.49 | 3.47e-07 |
| idx_tsa_dn_cluster3 | Strongly down-regulated at 8-96 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 3) | 108 | 0.27 | 6 | 22.47 | 3.52e-07 |
| bay_pbmc_6hr_up | Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 1.17 | 10 | 8.52 | 4.40e-07 |
| bleo_human_lymph_high_24hrs_up | Up-regulated at 24 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin | 197 | 0.49 | 7 | 14.37 | 7.68e-07 |
| il2_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 510 | 1.26 | 10 | 7.93 | 8.35e-07 |
| tzd_adip_dn | Downregulated by treatment of mature murine adipocytes with the PPARgamma agonist troglitazone | 29 | 0.07 | 4 | 55.80 | 8.44e-07 |
| il2_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 511 | 1.26 | 10 | 7.92 | 8.50e-07 |
| pubertal_mammary | Differentially expressed (> 2-fold) in the developing mouse mammary gland at any time point between 3- and 7-weeks of age. | 1260 | 3.11 | 15 | 4.82 | 1.00e-06 |
| bleo_mouse_lymph_high_24hrs_dn | Down-regulated at 24 hours following treatment of mouse lymphocytes (TK 3.7.2C) with a high dose of bleomycin | 71 | 0.18 | 5 | 28.49 | 1.05e-06 |
| il2_pbmc_6hr_up | Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 530 | 1.31 | 10 | 7.63 | 1.18e-06 |
| cmv_all_dn | Downregulated at any timepoint following infection of primary human foreskin fibroblasts with CMV | 213 | 0.53 | 7 | 13.29 | 1.29e-06 |
| tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 3.27 | 15 | 4.59 | 1.78e-06 |
| cmv_hcmv_timecourse_all_dn | Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) | 839 | 2.07 | 12 | 5.79 | 1.87e-06 |
| microrna_mammal | Predicted MicroRNA targets conserved across human, mouse and rat | 1331 | 3.29 | 15 | 4.56 | 1.95e-06 |
| caries_pulp_up | Up-regulated in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth | 410 | 1.01 | 8 | 7.89 | 1.07e-05 |
| cmv-uv_hcmv_6hrs_dn | Down-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus | 207 | 0.51 | 6 | 11.73 | 1.52e-05 |
| microrna_vertebrate | Predicted MicroRNA targets conserved across human, mouse, rat, zebrafish and fugu | 214 | 0.53 | 6 | 11.34 | 1.83e-05 |
| jnk_up | Upregulated by expression of constitutively active JNK in 3T3 cells | 66 | 0.16 | 4 | 24.52 | 2.38e-05 |
| bay_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 606 | 1.50 | 9 | 6.01 | 2.63e-05 |
| cmv_24hrs_dn | Downregulated at 24hrs following infection of primary human foreskin fibroblasts with CMV | 140 | 0.35 | 5 | 14.45 | 2.92e-05 |
| pod1_ko_up | Up-regulated in glomeruli isolated from Pod1 knockout mice, versus wild-type controls | 508 | 1.26 | 8 | 6.37 | 4.87e-05 |
| adip_vs_preadip_dn | Downregulated in mature murine adipocytes (7 day differentiation) vs. preadipocytes (6 hr differentiation) | 84 | 0.21 | 4 | 19.26 | 6.15e-05 |
| il6_fibro_up | Upregulated following IL-6 treatment in normal skin fibroblasts | 85 | 0.21 | 4 | 19.04 | 6.44e-05 |
| caries_pulp_high_up | Highly up-regulated (>4-fold) in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth | 168 | 0.42 | 5 | 12.04 | 6.94e-05 |
| bay_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 544 | 1.34 | 8 | 5.95 | 7.82e-05 |
| insulin_adip_insens_up | Up-regulated by insulin in murine adipocytes, and continue to respond following induction of insulin-resistance with TNFalpha treatment | 37 | 0.09 | 3 | 32.80 | 1.10e-04 |
| pubertal_mammary_3-4wks_up | Up-regulated > 1.5-fold in the developing mouse mammary gland between 3 and 4 weeks of age. | 301 | 0.74 | 6 | 8.06 | 1.20e-04 |
| prmt5_kd_up | Up-regulated by stable RNAi knock-down of PRMT5 in NIH 3T3 cells | 306 | 0.76 | 6 | 7.93 | 1.32e-04 |
| zmpste24_ko_dn | Fifty genes most strongly down-regulated in liver tissue from mice deficient in the lamin-protease Zmpste24/Face1, versus wild-type controls | 42 | 0.10 | 3 | 28.90 | 1.61e-04 |
| cmv_hcmv_6hrs_dn | Down-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus (CMV) | 109 | 0.27 | 4 | 14.85 | 1.69e-04 |
| idx_tsa_up_cluster1 | Strongly up-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 1) | 44 | 0.11 | 3 | 27.58 | 1.85e-04 |
| cancer_neoplastic_meta_up | Sixty-seven genes commonly upregulated in cancer relative to normal tissue, from a meta-analysis of the OncoMine gene expression database | 115 | 0.28 | 4 | 14.07 | 2.07e-04 |
| inos_all_dn | Downregulated following iNOS induction in hepatocytes (Tables 3-17) | 117 | 0.29 | 4 | 13.83 | 2.22e-04 |
| uvb_scc_dn | Downregulated by UV-B light in squamous cell carinoma cells | 219 | 0.54 | 5 | 9.24 | 2.39e-04 |
| idx_tsa_dn_cluster6 | Strongly down-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 6) | 48 | 0.12 | 3 | 25.28 | 2.40e-04 |
| hdaci_colon_cur2hrs_up | Upregulated by curcumin at 2 hrs in SW260 colon carcinoma cells | 49 | 0.12 | 3 | 24.77 | 2.56e-04 |
| tgfb_hmvec_2hr_dn | Down-regulated 2 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 353 | 0.87 | 6 | 6.88 | 2.83e-04 |
| pubertal_mammary_4-5wks_up | Up-regulated > 1.5-fold in the developing mouse mammary gland between 4 and 5 weeks of age. | 368 | 0.91 | 6 | 6.60 | 3.53e-04 |
| il2_pbmc_48hr_dn | Down-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 531 | 1.31 | 7 | 5.33 | 4.16e-04 |
| h2o2_csbdiff_c1 | Stronger induction by H2O2 in CSB-null fibroblasts, compared to CSB-rescued (Table 2, cluster 1) | 58 | 0.14 | 3 | 20.92 | 4.21e-04 |
| uvc_ttd_8hr_dn | Down-regulated at 8 hours following treatment of XPB/TTD fibroblasts with 3 J/m^2 UVC | 382 | 0.94 | 6 | 6.35 | 4.29e-04 |
| igf1_nih3t3_up | Up-regulated by treatment with IGF1 of NIH3T3 cells overexpressing IGF1R (Tables 1+3) | 61 | 0.15 | 3 | 19.90 | 4.88e-04 |
| gh_exogenous_early_dn | Down-regulated at early time points (1-4 hours) following treatment of mammary carcinoma cells (MCF-7) with exogenous human growth hormone | 14 | 0.03 | 2 | 57.79 | 5.45e-04 |
| adip_diff_cluster2 | Strongly upregulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 2) | 64 | 0.16 | 3 | 18.96 | 5.62e-04 |
| uv_unique_fibro_dn | Down-regulated at any timepoint by treatment of human fibroblasts with UV light, but not bygamma radiation or 4-NQO | 66 | 0.16 | 3 | 18.39 | 6.15e-04 |
| sarcomas_histiocytoma_up | Top 20 positive significant genes associated with malignant fibrous histiocytomas, versus other soft-tissue tumors. | 16 | 0.04 | 2 | 50.57 | 7.17e-04 |
| sarcomas_synovial_up | Top 20 positive significant genes associated with synovial sarcomas, versus other soft-tissue tumors. | 16 | 0.04 | 2 | 50.57 | 7.17e-04 |
| microrna_human | Predicted human MicroRNA targets | 2276 | 5.63 | 15 | 2.67 | 7.36e-04 |
| uv-cmv_unique_hcmv_6hrs_dn | Down-regulated in fibroblasts at 6 hours following infection with UV-inactivated CMV, but not untreated CMV | 164 | 0.41 | 4 | 9.87 | 7.92e-04 |
| stress_genotoxic_specific_dn | Genes down-regulated 4 hours following genotoxic stress that discriminate genotoxic from non-genotoxic stress | 74 | 0.18 | 3 | 16.40 | 8.59e-04 |
| senescence_hff_dn | Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). | 299 | 0.74 | 5 | 6.76 | 9.75e-04 |
| hdaci_colon_cur_up | Upregulated by curcumin at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 174 | 0.43 | 4 | 9.30 | 9.86e-04 |
| hdaci_colon_cluster9 | Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 9, associated with histone hyperAc) | 78 | 0.19 | 3 | 15.56 | 1.00e-03 |
| stress_tpa_specific_up | Genes up-regulated 4 hours following TPA treatment that discriminate TPA from other stress agents | 78 | 0.19 | 3 | 15.56 | 1.00e-03 |
| calres_mouse_dn | Downregulated in the gastrocnemius muscle of aged (30-month) mice subjected to caloric restriction since young adulthood vs. age-matched controls | 79 | 0.20 | 3 | 15.36 | 1.04e-03 |
| hdaci_colon_sul30min_dn | Downregulated by sulindac at 30 min in SW260 colon carcinoma cells | 79 | 0.20 | 3 | 15.36 | 1.04e-03 |
| ifn_gamma_up | Upregulated 2-fold in HT1080 cells 6 hours following treatment with interferon gamma | 80 | 0.20 | 3 | 15.17 | 1.08e-03 |
| arthritis_mouse_common_up | Up-regulated in joint tissue from both severely arthritic HTLV-I transgenic mice and IL-1Ra knock-out mice, versus wild-type littermate controls. | 459 | 1.13 | 6 | 5.29 | 1.11e-03 |
| as3_fibro_c5 | Downregulated moderately by sodium arsenite in fibroblasts (Cluster 5) | 20 | 0.05 | 2 | 40.45 | 1.13e-03 |
| cmv_hcmv_timecourse_24hrs_dn | Down-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 24 hours | 82 | 0.20 | 3 | 14.80 | 1.16e-03 |
| gh_autocrine_dn | Down-regulated following stable autocrine expression of human growth hormone in mammary carcinoma cells (MCF-7) | 189 | 0.47 | 4 | 8.56 | 1.34e-03 |
| dsrna_dn | Downregulated by dsRNA (polyI:C) in IFN-null GRE cells | 24 | 0.06 | 2 | 33.71 | 1.63e-03 |
| vegf_huvec_up | 20 genes with the largest fold-change up-regulation at any time point (30min to 24 hours) after VEGF treatment in human umbilical vein endothelial cells | 24 | 0.06 | 2 | 33.71 | 1.63e-03 |
| uvb_nhek1_up | Upregulated by UV-B light in normal human epidermal keratinocytes | 336 | 0.83 | 5 | 6.02 | 1.63e-03 |
| bay_pbmc_24hr_up | Up-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 202 | 0.50 | 4 | 8.01 | 1.70e-03 |
| hdaci_colon_sul_dn | Downregulated by sulindac at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 340 | 0.84 | 5 | 5.95 | 1.71e-03 |
| hdaci_colon_but24hrs_up | Upregulated by butyrate at 24 hrs in SW260 colon carcinoma cells | 95 | 0.23 | 3 | 12.77 | 1.76e-03 |
| htert_up | Upregulated in hTERT-immortalized fibroblasts vs. non-immortalized controls | 97 | 0.24 | 3 | 12.51 | 1.87e-03 |
| uvb_nhek1_c2 | Upregulated by UV-B light in normal human epidermal keratinocytes, cluster 2 | 28 | 0.07 | 2 | 28.90 | 2.21e-03 |
| brca1_overexp_dn | Downregulated by induction of exogenous BRCA1 in EcR-293 cells | 220 | 0.54 | 4 | 7.36 | 2.32e-03 |
| emt_up | Up-regulated during the TGFbeta-induced epithelial-to-mesenchymal transition (EMT) of Ras-transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late-stage tumor progression and metastasis) | 105 | 0.26 | 3 | 11.56 | 2.35e-03 |
| bleo_human_lymph_high_4hrs_up | Up-regulated at 4 hours following treatment of human lymphocytes (TK6) with a high dose of bleomycin | 32 | 0.08 | 2 | 25.28 | 2.88e-03 |
| dnmt1_ko_up | Upregulated following conditional knock-out of DNMT1 in MEFs | 117 | 0.29 | 3 | 10.37 | 3.18e-03 |
| brca_brca1_neg | Genes whose expression is consistently negatively correlated with brca1 germline status in breast cancer - higher expression is associated with BRCA1 tumors | 250 | 0.62 | 4 | 6.47 | 3.66e-03 |
| cmv_hcmv_timecourse_24hrs_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 24 hours | 123 | 0.30 | 3 | 9.87 | 3.66e-03 |
| ros_mouse_aorta_dn | Down-regulated in mouse aorta by chronic treatment with PPARgamma agonist rosiglitazone | 127 | 0.31 | 3 | 9.56 | 4.01e-03 |
| elongina_ko_up | Upregulated in MES cells from elongin-A knockout mice | 263 | 0.65 | 4 | 6.15 | 4.38e-03 |
| avoidance_dn | Down-regulated in hippocampi from the Syracuse high-avoidance (SHA) rat line, versus Syracuse low-avoidance (SLA) rat line. | 40 | 0.10 | 2 | 20.23 | 4.48e-03 |
| bap_mcf7_dn | Down-regulated at least 1.4-fold following treatment of MCF-7 human breast carcinoma cells with carcinogen benzo(a)pyrene (BaP), at any time point from 6-48 hours and at any concentration from 0.25-5 microM. | 135 | 0.33 | 3 | 8.99 | 4.75e-03 |
| hdaci_colon_but48hrs_up | Upregulated by butyrate at 48 hrs in SW260 colon carcinoma cells | 135 | 0.33 | 3 | 8.99 | 4.75e-03 |
| arthritis_mouse_il1ko_up | Up-regulated in joint tissue from severely arthritic 13 week-old IL-1Ra knock-out mice, versus wild-type littermate controls. | 271 | 0.67 | 4 | 5.97 | 4.87e-03 |
| 5fu_resist_gastric_up | Upregulated in gastric cancer cell lines reistant to 5-fluorouracil, compared to parent chemosensitive lines | 42 | 0.10 | 2 | 19.26 | 4.93e-03 |
| cited1_ko_het_up | Up-regulated in pubertal mammary glands from CITED1 knockout mice, which display disturbed mammary development, versus heterozygotes | 43 | 0.11 | 2 | 18.82 | 5.16e-03 |
| brca_er_neg | Genes whose expression is consistently negatively correlated with estrogen receptor status in breast cancer - higher expression is associated with ER-negative tumors | 1519 | 3.75 | 10 | 2.66 | 5.29e-03 |
| uvc_high_all_dn | Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9) | 634 | 1.57 | 6 | 3.83 | 5.41e-03 |
| ifn_beta_up | Upregulated 2-fold in HT1080 cells 6 hours following treatment with interferon beta | 143 | 0.35 | 3 | 8.49 | 5.57e-03 |
| pubertal_mammary_5-6wks_up | Up-regulated > 1.5-fold in the developing mouse mammary gland between 5 and 6 weeks of age. | 143 | 0.35 | 3 | 8.49 | 5.57e-03 |
| o6bg_resist_medulloblastoma_up | Up-regulated in a medulloblastoma cell line resistant to both BCNU and O6-BG, compared to sensitive parent line (D-341 MED) | 46 | 0.11 | 2 | 17.59 | 5.88e-03 |
| dac_panc_up | Upregulated by DAC treatment in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells | 654 | 1.62 | 6 | 3.71 | 6.26e-03 |
| heatshock_hela_4hr_dn | Down-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 1829 | 4.52 | 11 | 2.43 | 6.82e-03 |
| heatshock_hela_4hr_up | Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 675 | 1.67 | 6 | 3.60 | 7.26e-03 |
| bay_pbmc_6hr_dn | Down-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 483 | 1.19 | 5 | 4.19 | 7.50e-03 |
| cmv_hcmv_timecourse_all_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) | 895 | 2.21 | 7 | 3.16 | 7.60e-03 |
| uvc_high_d9_dn | Progressively down-regulated through 24 hrs following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d9) | 53 | 0.13 | 2 | 15.27 | 7.74e-03 |
| cmv_uv-cmv_common_hcmv_6hrs_dn | Down-regulated in fibroblasts at 6 hours following infection with either human cytomegalovirus (CMV) or UV-inactivated CMV | 54 | 0.13 | 2 | 14.98 | 8.03e-03 |
| uvc_xpcs_8hr_dn | Down-regulated at 8 hours following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC | 911 | 2.25 | 7 | 3.11 | 8.32e-03 |
| ifn_any_up | Upregulated 2-fold in HT1080 cells 6 hours following treatment with any of interferons alpha, beta and gamma | 172 | 0.43 | 3 | 7.06 | 9.23e-03 |
| as3_fibro_dn | Downregulated by sodium arsenite in fibroblasts (Clusters 4, 5, and 6) | 59 | 0.15 | 2 | 13.71 | 9.52e-03 |
| hsc_hscandprogenitors_fetal | Up-regulated in mouse hematopoietic stem cells and progenitors from fetal liver (HSC and Progenitors Shared) | 717 | 1.77 | 6 | 3.39 | 9.58e-03 |
| hsc_hscandprogenitors_shared | Up-regulated in mouse hematopoietic stem cells and progenitors from both adult bone marrow and fetal liver (Cluster iii, HSC and Progenitors Shared) | 717 | 1.77 | 6 | 3.39 | 9.58e-03 |