L2L Microarray Analysis Tool

regulation of chemokine biosynthetic process

115.58

1.27e-04

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines.

8

0.02

regulation of interleukin-6 biosynthetic process

101.14

1.69e-04

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.

8

0.02

101.14

1.69e-04

chemokine production

The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

9

0.02

chemokine biosynthetic process

89.90

2.17e-04

The chemical reactions and pathways resulting in the formation of chemokines, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions.

9

0.02

chemokine metabolic process

89.90

2.17e-04

The chemical reactions and pathways involving chemokines, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions.

9

0.02

89.90

2.17e-04

interleukin-6 production

The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

10

0.02

interleukin-6 biosynthetic process

80.91

2.71e-04

The chemical reactions and pathways resulting in the formation of interleukin-6.

10

0.02

80.91

2.71e-04

sodium ion transport

The directed movement of sodium ions (Na+) into, out of, within or between cells.

124

0.31

13.05

2.77e-04

thermoregulation

A homeostatic process by which an organism modulates its internal body temperature.

12

0.03

67.42

3.97e-04

fibrinolysis

An ongoing process that solubilizes fibrin, chiefly by the proteolytic action of plasmin, resulting in the removal of small blood clots.

12

0.03

regulation of blood coagulation

67.42

3.97e-04

locomotory behavior

The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.

252

0.62

5

8.03

4.53e-04

Any process that modulates the frequency, rate or extent of blood coagulation.

15

0.04

negative regulation of blood coagulation

53.94

6.28e-04

Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation.

15

0.04

adrenal gland development

53.94

6.28e-04

The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells.

18

0.04

negative regulation of coagulation

44.95

9.11e-04

Any process that stops, prevents or reduces the frequency, rate or extent of coagulation.

18

0.04

regulation of coagulation

44.95

9.11e-04

Any process that modulates the frequency, rate or extent of coagulation, the process by which a fluid solution, or part of it, changes into a solid or semisolid mass.

19

0.05

42.58

1.02e-03

chemotaxis

The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).

179

0.44

9.04

1.09e-03

taxis

The directed movement of a motile cell or organism in response to an external stimulus.

179

0.44

regulation of transforming growth factor beta receptor signaling pathway

9.04

1.09e-03

Any process that modulates the frequency, rate or extent of activity of any TGFbeta receptor signaling pathway.

21

0.05

determination of left/right symmetry

38.53

1.24e-03

The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.

24

0.06

33.71

1.63e-03

neutrophil chemotaxis

The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.

24

0.06

33.71

1.63e-03

apoptosis

A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface.

1078

2.66

3.38

1.72e-03

programmed cell death

Cell death resulting from activation of endogenous cellular processes.

1086

2.68

determination of symmetry

3.35

1.81e-03

The establishment of an organism's body plan or part of an organism such that a similar arrangement in form and relationship of parts around a common axis, or around each side of a plane is created.

26

0.06

determination of bilateral symmetry

31.12

1.91e-03

The establishment of an organism's body plan or part of an organism with respect to a single longitudinal plane. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.

26

0.06

pattern specification process

31.12

1.91e-03

The developmental processes that result in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.

218

0.54

7.42

2.25e-03

cell death

The specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.

1152

2.85

3.16

2.68e-03

death

A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism.

1152

2.85

3.16

2.68e-03

leukocyte chemotaxis

The movement of a leukocyte in response to an external stimulus.

32

0.08

positive regulation of progression through cell cycle

25.28

2.88e-03

Any process that activates or increases the frequency, rate or extent of progression through the cell cycle.

33

0.08

24.52

3.07e-03

cell development

The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.

1692

4.18

11

2.63

3.90e-03

leukocyte migration

The movement of leukocytes within or between different tissues and organs of the body.

39

0.10

20.75

4.26e-03

regulation of growth

Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development.

262

0.65

striated muscle development

6.18

4.32e-03

The developmental sequence of events leading to the formation of adult muscle that occurs in the animal and in cultured cells. In vertebrate skeletal muscle the main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.

137

0.34

3

8.86

4.95e-03

behavior

The specific actions or reactions of an organism in response to external or internal stimuli. Patterned activity of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.

445

1.10

5

4.55

5.36e-03

acute-phase response

Process involving non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals.

44

0.11

18.39

5.40e-03

blood vessel development

The process whose specific outcome is the progression of the blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.

283

0.70

5.72

5.66e-03

vasculature development

The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure.

288

0.71

endocrine system development

5.62

6.02e-03

Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes.

47

0.12

17.21

6.14e-03

forebrain development

The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).

56

0.14

positive regulation of cytokine biosynthetic process

14.45

8.61e-03

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines.

58

0.14

central nervous system development

13.95

9.21e-03

The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.

332

0.82