L2L Microarray Analysis Tool
Results for D01A.profile.u50
| Results summary | View all lists in L2L MDB | View all genes in D01A.profile.u50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| alk5_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 0.86 | 21 | 24.48 | 1.95e-22 |
| alk5_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). | 347 | 0.86 | 21 | 24.48 | 1.95e-22 |
| alk1_hmvec_2hr_up | Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 24 | 16.37 | 2.52e-21 |
| alk1_hmvec_4hr_up | Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). | 593 | 1.47 | 24 | 16.37 | 2.52e-21 |
| il2_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 510 | 1.26 | 17 | 13.48 | 3.49e-14 |
| bay_pbmc_4hr_up | Up-regulated at 4 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 544 | 1.34 | 17 | 12.64 | 9.82e-14 |
| et743_hela_up | Upregulated by Et-743 in HeLa cells | 99 | 0.24 | 9 | 36.78 | 4.88e-12 |
| tgfb_hmvec_4hr_dn | Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1321 | 3.27 | 21 | 6.43 | 4.85e-11 |
| bay_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 606 | 1.50 | 13 | 8.68 | 6.94e-09 |
| stress_arsenic_specific_up | Genes up-regulated 4 hours following arsenic treatment that discriminate arsenic from other stress agents | 266 | 0.66 | 9 | 13.69 | 3.12e-08 |
| genotoxins_all_24hrs_reg | Genes most consistently regulated in mouse lymphocytes (TK 3.7.2C) at 24 hours by all six genotoxins tested (cisplatin, methyl methanesulfonate, mitomycin C, taxol, hydroxyurea and etoposide) | 49 | 0.12 | 5 | 41.28 | 1.61e-07 |
| irs1_ko_adip_up | Up-regulated in brown preadipocytes from Irs1-knockout mice, which display severe defects in adipocyte differentiation, versus wild-type controls | 159 | 0.39 | 7 | 17.81 | 1.81e-07 |
| uvb_nhek3_all | Regulated by UV-B light in normal human epidermal keratinocytes | 751 | 1.86 | 12 | 6.46 | 5.97e-07 |
| bay-il2_pbmc_late_dn | Down-regulated at 24-48 hours following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist, compared to recombinant IL-2. | 205 | 0.51 | 7 | 13.81 | 1.00e-06 |
| heatshock_hela_4hr_up | Up-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 675 | 1.67 | 11 | 6.59 | 1.44e-06 |
| adipocyte_brca_up | Upregulated in breast cancer cells (MCF-7) treated with adipocyte-conditioned growth media | 14 | 0.03 | 3 | 86.69 | 5.39e-06 |
| heatshock_hela_2hr_up | Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 177 | 0.44 | 6 | 13.71 | 6.23e-06 |
| brca_er_neg | Genes whose expression is consistently negatively correlated with estrogen receptor status in breast cancer - higher expression is associated with ER-negative tumors | 1519 | 3.75 | 15 | 3.99 | 9.30e-06 |
| cmv-uv_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with UV-inactivated human cytomegalovirus | 226 | 0.56 | 6 | 10.74 | 2.48e-05 |
| stemcell_hematopoietic_up | Enriched in mouse hematopoietic stem cells, compared to differentiated brain and bone marrow cells | 2092 | 5.17 | 17 | 3.29 | 2.91e-05 |
| 5azac-tsa_hepg2_dn | Down-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC) and 24 hrs treatment with both 5azaC and 500 nM trichostatin A (TSA). | 2343 | 5.79 | 18 | 3.11 | 3.55e-05 |
| camptothecin_probcell_up | Up-regulated in pro-B cells (FL5.12) following treatment with camptothecin | 28 | 0.07 | 3 | 43.34 | 4.72e-05 |
| insulin_adip_sens_dn | Down-regulated by insulin in murine adipocytes, but response is blunted following induction of insulin-resistance with TNFalpha treatment | 29 | 0.07 | 3 | 41.85 | 5.26e-05 |
| il2_pbmc_6hr_up | Up-regulated at 6hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 530 | 1.31 | 8 | 6.11 | 6.53e-05 |
| uvb_nhek3_c7 | Regulated by UV-B light in normal human epidermal keratinocytes, cluster 7 | 86 | 0.21 | 4 | 18.82 | 6.74e-05 |
| brca1_sw480_dn | Down-regulated by infection of human colon adenocarcinoma cells (SW480) with Ad-BRCA1, versus Ad-LacZ control | 33 | 0.08 | 3 | 36.78 | 7.80e-05 |
| uvc_high_all_up | Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) | 34 | 0.08 | 3 | 35.69 | 8.53e-05 |
| irs_ko_adip_up | Progressively up-regulated in brown preadipocytes from four Irs-knockout mouse lines with increasingly severe defects in adipocyte differentiation (wt, Irs4 KO, Irs2 KO, Irs3 KO, Irs1 KO) | 36 | 0.09 | 3 | 33.71 | 1.01e-04 |
| cmv_hcmv_timecourse_all_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints) | 895 | 2.21 | 10 | 4.52 | 1.02e-04 |
| cmvuv-cmv_common_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with either human cytomegalovirus (CMV) or UV-inactivated CMV | 37 | 0.09 | 3 | 32.80 | 1.10e-04 |
| ifna_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following treatment with interferon-alpha | 103 | 0.25 | 4 | 15.71 | 1.36e-04 |
| cmv_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following infection with human cytomegalovirus (CMV) | 46 | 0.11 | 3 | 26.38 | 2.12e-04 |
| dac_panc_up | Upregulated by DAC treatment in at least one of four pancreatic cancer cell lines, but not in normal (HPDE) cells | 654 | 1.62 | 8 | 4.95 | 2.71e-04 |
| tsa_hepatoma_cancer_dn | Cancer-related genes down-regulated in any of four human hepatoma cell lines following 24-hour treatment with 200ng/mL of trichostatin A | 51 | 0.13 | 3 | 23.80 | 2.88e-04 |
| il2_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 511 | 1.26 | 7 | 5.54 | 3.31e-04 |
| vegf_huvec_2hrs_up | Up-regulated 2 hours after VEGF treatment in human umbilical vein endothelial cells | 54 | 0.13 | 3 | 22.47 | 3.41e-04 |
| il1_cornea_up | Upregulated in corneal fibroblasts after interleukin-1 treatment (Tables 1 and 2) | 136 | 0.34 | 4 | 11.90 | 3.93e-04 |
| hypoxia_normal_up | Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) | 376 | 0.93 | 6 | 6.46 | 3.95e-04 |
| zmpste24_ko_up | Fifty genes most strongly up-regulated in liver tissue from mice deficient in the lamin-protease Zmpste24/Face1, versus wild-type controls | 57 | 0.14 | 3 | 21.29 | 4.00e-04 |
| il2_pbmc_2hr_up | Up-regulated at 2 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 66 | 0.16 | 3 | 18.39 | 6.15e-04 |
| il2_pbmc_30min_up | Up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 66 | 0.16 | 3 | 18.39 | 6.15e-04 |
| caries_pulp_up | Up-regulated in pulpal tissue from extracted carious teeth (cavities), compared to tissue from extracted healthy teeth | 410 | 1.01 | 6 | 5.92 | 6.21e-04 |
| uvc_high_b2_up | Up-regulated at 18-24 hours following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster b2) | 15 | 0.04 | 2 | 53.94 | 6.28e-04 |
| 5azac_hepg2_dn | Down-regulated in human hepatoma cells (HepG2) following 48 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC). | 1830 | 4.52 | 13 | 2.87 | 8.28e-04 |
| hypoxia_reg_up | Upregulated by hypoxia in renal cells, and downregulated with reoxygenation | 80 | 0.20 | 3 | 15.17 | 1.08e-03 |
| brca1_overexp_prostate_up | Up-regulated with stable, ectopic overexpression of BRCA1 in DU-145 human prostate cancer cell lines, compared to neo-only controls | 308 | 0.76 | 5 | 6.57 | 1.11e-03 |
| bay_pbmc_30min_up | up-regulated at 30 min following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 82 | 0.20 | 3 | 14.80 | 1.16e-03 |
| cmv_hcmv_timecourse_14hrs_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 14 hours | 84 | 0.21 | 3 | 14.45 | 1.24e-03 |
| il2_pbmc_24hr_dn | Down-regulated at 24 hr following treatment of peripheral blood mononuclear cells (PBMC) with recombinant IL-2. | 646 | 1.60 | 7 | 4.38 | 1.30e-03 |
| bay_pbmc_48hr_up | Up-regulated at 48 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 1.17 | 6 | 5.11 | 1.32e-03 |
| bay_pbmc_6hr_up | Up-regulated at 6 hr following treatment of peripheral blood mononuclear cells (PBMC) with BAY 50-4798, an IL-2 receptor agonist. | 475 | 1.17 | 6 | 5.11 | 1.32e-03 |
| hdaci_colon_sul_up | Upregulated by sulindac at any timepoint up to 48 hrs in SW260 colon carcinoma cells | 192 | 0.47 | 4 | 8.43 | 1.42e-03 |
| ifnalpha_resist_dn | Down-regulated in mycosis fungoides (cutaneous T-cell lymphoma) T-cells resistant to IFN-alpha, compared to sensitive parent cell line | 25 | 0.06 | 2 | 32.36 | 1.77e-03 |
| tgfb_hmvec_2hr_up | Up-regulated 2 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1997 | 4.94 | 13 | 2.63 | 1.78e-03 |
| tgfb_hmvec_4hr_up | Up-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. | 1997 | 4.94 | 13 | 2.63 | 1.78e-03 |
| dac_cgi_bladder_up | Upregulated by DAC treatment in T24 bladder carcinoma cells, with 5' CpG island | 26 | 0.06 | 2 | 31.12 | 1.91e-03 |
| baf57_bt549_up | Up-regulated following stable re-expression of BAF57 in Bt549 breast cancer cells that lack functional BAF57 | 364 | 0.90 | 5 | 5.56 | 2.30e-03 |
| 5fu_resist_gastric_dn | Downregulated in gastric cancer cell lines reistant to 5-fluorouracil, compared to parent chemosensitive lines | 30 | 0.07 | 2 | 26.97 | 2.54e-03 |
| idx_tsa_dn_cluster2 | Progressively down-regulated from 8-96 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 2) | 114 | 0.28 | 3 | 10.65 | 2.96e-03 |
| cpr_null-low_liver_up | Up-regulated in mouse liver tissue from mice in which NADPH-cytochrome P450 reductase (CPR) was specifically deleted in the liver by cre-lox recombination, versus mice with low expression of CPR | 34 | 0.08 | 2 | 23.80 | 3.25e-03 |
| aged_mouse_retina_any_up | Up-regulated in the retina of 16-month aged mice from any of four strains (S8, S10, SR1, B6J), versus 3-month young controls | 36 | 0.09 | 2 | 22.47 | 3.64e-03 |
| uvb_nhek3_c3 | Regulated by UV-B light in normal human epidermal keratinocytes, cluster 3 | 37 | 0.09 | 2 | 21.87 | 3.84e-03 |
| elongina_ko_up | Upregulated in MES cells from elongin-A knockout mice | 263 | 0.65 | 4 | 6.15 | 4.38e-03 |
| uvb_nhek3_c8 | Regulated by UV-B light in normal human epidermal keratinocytes, cluster 8 | 132 | 0.33 | 3 | 9.19 | 4.46e-03 |
| hdaci_colon_sul12hrs_up | Upregulated by sulindac at 12 hrs in SW260 colon carcinoma cells | 40 | 0.10 | 2 | 20.23 | 4.48e-03 |
| hdaci_colon_sul48hrs_up | Upregulated by sulindac at 48 hrs in SW260 colon carcinoma cells | 140 | 0.35 | 3 | 8.67 | 5.25e-03 |
| idx_tsa_up_cluster1 | Strongly up-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 1) | 44 | 0.11 | 2 | 18.39 | 5.40e-03 |
| cmv_hcmv_timecourse_12hrs_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 12 hours | 45 | 0.11 | 2 | 17.98 | 5.64e-03 |
| oxstress_breastca_up | Upregulated by H2O2, Menadione and t-BH in breast cancer cells | 45 | 0.11 | 2 | 17.98 | 5.64e-03 |
| pubertal_mammary_4-5wks_dn | Down-regulated > 1.5-fold in the developing mouse mammary gland between 4 and 5 weeks of age. | 283 | 0.70 | 4 | 5.72 | 5.66e-03 |
| ifna_uv-cmv_common_hcmv_6hrs_up | Up-regulated in fibroblasts at 6 hours following either infection with UV-inactivated CMV or interferon-alpha | 47 | 0.12 | 2 | 17.21 | 6.14e-03 |
| p53_brca1_up | Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 | 49 | 0.12 | 2 | 16.51 | 6.65e-03 |
| brg1_sw13_up | Up-regulated by transient expression of BRG1 at 24 hours in human, BRG1-lacking SW-13 cells | 51 | 0.13 | 2 | 15.86 | 7.19e-03 |
| hypoxia_review | Genes known to be induced by hypoxia | 160 | 0.40 | 3 | 7.59 | 7.58e-03 |
| hdaci_colon_but48hrs_dn | Downregulated by butyrate at 48 hrs in SW260 colon carcinoma cells | 165 | 0.41 | 3 | 7.36 | 8.25e-03 |
| brca_prognosis_neg | Genes whose expression is consistently negatively correlated with breast cancer outcomes - higher expression is associated with metastasis and poor prognosis | 166 | 0.41 | 3 | 7.31 | 8.38e-03 |
| serum_fibroblast_core_dn | Core group of genes consistently down-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in quiescent cells, not cell-cycle dependent) | 319 | 0.79 | 4 | 5.07 | 8.55e-03 |
| dac_bladder_up | Upregulated by DAC treatment in T24 bladder carcinoma cells | 60 | 0.15 | 2 | 13.48 | 9.83e-03 |