L2L L2L Microarray Analysis Tool

Results for C08E.profile.d50

Results summary View all lists in L2L MDB View all genes in C08E.profile.d50
List Name Description Total
senescence_hela_dn Down-regulated in HeLa/HPV16E6 cells 6 days following induction of senescence by repression of HPV E7 via HPV E2 and subsequent reactivation of Rb. 341 0.84 11 13.05 1.54e-09
5azac_hepg2_dn Down-regulated in human hepatoma cells (HepG2) following 48 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC). 1830 4.52 15 3.32 7.58e-05
pod1_ko_up Up-regulated in glomeruli isolated from Pod1 knockout mice, versus wild-type controls 508 1.26 7 5.57 3.20e-04
idx_tsa_up_cluster3 Strongly up-regulated at 16-24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 3) 136 0.34 4 11.90 3.93e-04
senescence_rep-ind_dn Down-regulated in models of both replicative (high-passge human foreskin fibroblast) and induced (repression of E7 in HeLa) cellular senescence. 171 0.42 4 9.46 9.25e-04
stemcell_embryonic_up Enriched in mouse embryonic stem cells, compared to differentiated brain and bone marrow cells 1989 4.92 13 2.64 1.72e-03
stemcell_neural_up Enriched in mouse neural stem cells, compared to differentiated brain and bone marrow cells 2805 6.93 16 2.31 2.17e-03
tpa_skin_up Upregulated in murine dorsal skin cells 6 hours after treatment with the phorbol ester carcinogen TPA 31 0.08 2 26.10 2.71e-03
fsh_ovary_mcv152_dn Down-regulated in ovarian epithelial cells (MCV152) 72 hours following FSH treatment, compared to untreated 111 0.27 3 10.93 2.75e-03
uvc_high_all_dn Down-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters d1-d9) 634 1.57 6 3.83 5.41e-03
et743_sarcoma_dn Down-regulated following treatment with Et-743 at any timepoint in at least 8 of 11 sarcoma cell lines 459 1.13 5 4.41 6.09e-03
serum_fibroblast_core_up Core group of genes consistently up-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in activated cells, not cell-cycle dependent) 292 0.72 4 5.54 6.31e-03
senescence_hff_dn Down-regulated in primary human foreskin fibroblasts at replicative senescence (passage 26) compared to active replication (passage 8). 299 0.74 4 5.41 6.85e-03
prmt5_kd_up Up-regulated by stable RNAi knock-down of PRMT5 in NIH 3T3 cells 306 0.76 4 5.29 7.41e-03
adip_diff_cluster4 Strongly upregulated at 16 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 4) 56 0.14 2 14.45 8.61e-03

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