Results summary | View all lists in L2L MDB | View all genes in C03D.profile.ud50 |
List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
---|---|---|---|---|---|---|
heatshock_hela_2hr_dn | Down-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 223 | 1.10 | 6 | 5.44 | 9.36e-04 |
heatshock_hela_4hr_dn | Down-regulated at 4 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). | 1829 | 9.04 | 20 | 2.21 | 1.08e-03 |
et743_sarcoma_24hrs_dn | Down-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 163 | 0.81 | 5 | 6.20 | 1.40e-03 |
dac_cgi_fibro_dn | Downregulated by DAC treatment in LD419 fibroblast cells, with 5' CpG island | 12 | 0.06 | 2 | 33.71 | 1.56e-03 |
rcc_nl_up | Upregulated in VHL-rescued renal carcinoma vs. normal renal cells (Fig. 2d+e) | 899 | 4.44 | 12 | 2.70 | 2.11e-03 |
5azac_hepg2_dn | Down-regulated in human hepatoma cells (HepG2) following 48 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC). | 1830 | 9.05 | 19 | 2.10 | 2.50e-03 |
oxstress_breastca_dn | Downregulated by H2O2, Menadione and t-BH in breast cancer cells | 16 | 0.08 | 2 | 25.28 | 2.80e-03 |
dac_fibro_dn | Downregulated by DAC treatment in LD419 fibroblast cells | 17 | 0.08 | 2 | 23.80 | 3.16e-03 |
tsadac_hypometh_hyperac_ovca_up | Genes with basally hypomethylated promoters upregulated by the combination of TSA and DAC in ovarian carcinoma (CP70) cells, with hyperacetylated promoters upon activation | 17 | 0.08 | 2 | 23.80 | 3.16e-03 |
serum_fibroblast_cellcycle | Cell-cycle dependent genes regulated following exposure to serum in a variety of human fibroblast cell lines | 197 | 0.97 | 5 | 5.13 | 3.17e-03 |
17aag_ovca_dn | Down-regulated 24 hours following treatment of human ovarian cancer cells (A2780) with the HSP90 inhibitor 17AAG (60 nM) | 129 | 0.64 | 4 | 6.27 | 4.03e-03 |
tsa_hepg2_dn | Down-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 500 nM trichostatin A (TSA). | 1237 | 6.12 | 14 | 2.29 | 4.17e-03 |
et743_sarcoma_48hrs_dn | Down-regulated at48 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 304 | 1.50 | 6 | 3.99 | 4.38e-03 |
adip_diff_cluster5 | Strongly upregulated at 24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 5) | 67 | 0.33 | 3 | 9.06 | 4.57e-03 |
tsadac_hypometh_ovca_up | Genes with basally hypomethylated promoters upregulated by the combination of TSA and DAC in ovarian carcinoma (CP70) cells | 70 | 0.35 | 3 | 8.67 | 5.17e-03 |
middleage_dn | Downregulated in fibroblasts from middle-age individuals, compared to young | 23 | 0.11 | 2 | 17.59 | 5.77e-03 |
p21_p53_early_dn | Down-regulated at early timepoints (4-8 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent | 23 | 0.11 | 2 | 17.59 | 5.77e-03 |
cmv_hcmv_timecourse_14hrs_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 14 hours | 84 | 0.42 | 3 | 7.22 | 8.55e-03 |
h2o2_csbrescued_c1_up | Upregulated by H2O2 in CSB-rescued fibroblasts (Table 1, cluster 1) | 84 | 0.42 | 3 | 7.22 | 8.55e-03 |
et743_sarcoma_dn | Down-regulated following treatment with Et-743 at any timepoint in at least 8 of 11 sarcoma cell lines | 459 | 2.27 | 7 | 3.08 | 8.56e-03 |