L2L Microarray Analysis Tool
Results for C03D.profile.d50
| Results summary | View all lists in L2L MDB | View all genes in C03D.profile.d50 |
| List Name | Description | Total probes |
Expected matches |
Actual matches |
Fold Enrichment |
Binomial p-value |
|---|---|---|---|---|---|---|
| 17aag_ovca_dn | Down-regulated 24 hours following treatment of human ovarian cancer cells (A2780) with the HSP90 inhibitor 17AAG (60 nM) | 129 | 0.32 | 4 | 12.54 | 3.21e-04 |
| dac_cgi_fibro_dn | Downregulated by DAC treatment in LD419 fibroblast cells, with 5' CpG island | 12 | 0.03 | 2 | 67.42 | 3.97e-04 |
| adip_diff_cluster5 | Strongly upregulated at 24 hours during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 5) | 67 | 0.17 | 3 | 18.11 | 6.43e-04 |
| oxstress_breastca_dn | Downregulated by H2O2, Menadione and t-BH in breast cancer cells | 16 | 0.04 | 2 | 50.57 | 7.17e-04 |
| et743_sarcoma_24hrs_dn | Down-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 163 | 0.40 | 4 | 9.93 | 7.74e-04 |
| dac_fibro_dn | Downregulated by DAC treatment in LD419 fibroblast cells | 17 | 0.04 | 2 | 47.59 | 8.11e-04 |
| tsadac_hypometh_hyperac_ovca_up | Genes with basally hypomethylated promoters upregulated by the combination of TSA and DAC in ovarian carcinoma (CP70) cells, with hyperacetylated promoters upon activation | 17 | 0.04 | 2 | 47.59 | 8.11e-04 |
| 5azac_hepg2_dn | Down-regulated in human hepatoma cells (HepG2) following 48 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC). | 1830 | 4.52 | 13 | 2.87 | 8.28e-04 |
| stemcell_neural_up | Enriched in mouse neural stem cells, compared to differentiated brain and bone marrow cells | 2805 | 6.93 | 17 | 2.45 | 8.51e-04 |
| middleage_dn | Downregulated in fibroblasts from middle-age individuals, compared to young | 23 | 0.06 | 2 | 35.18 | 1.49e-03 |
| p21_p53_early_dn | Down-regulated at early timepoints (4-8 hrs) following ectopic expression of p21 (CDKN1A) in OvCa cells, p53-dependent | 23 | 0.06 | 2 | 35.18 | 1.49e-03 |
| serum_fibroblast_cellcycle | Cell-cycle dependent genes regulated following exposure to serum in a variety of human fibroblast cell lines | 197 | 0.49 | 4 | 8.21 | 1.56e-03 |
| uvb_scc_up | Upregulated by UV-B light in squamous cell carcinoma cells | 198 | 0.49 | 4 | 8.17 | 1.58e-03 |
| stemcell_embryonic_up | Enriched in mouse embryonic stem cells, compared to differentiated brain and bone marrow cells | 1989 | 4.92 | 13 | 2.64 | 1.72e-03 |
| o6bg_resist_medulloblastoma_dn | Up-regulated in a medulloblastoma cell line resistant to both BCNU and O6-BG, compared to sensitive parent line (D-341 MED) | 109 | 0.27 | 3 | 11.13 | 2.61e-03 |
| wnt3a_mammary_up | Up-regulated in normal mouse mammary gland cells following treatment with Wnt3A (top 124 genes). | 133 | 0.33 | 3 | 9.12 | 4.56e-03 |
| et743_sarcoma_dn | Down-regulated following treatment with Et-743 at any timepoint in at least 8 of 11 sarcoma cell lines | 459 | 1.13 | 5 | 4.41 | 6.09e-03 |
| 5azac-tsa_hepg2_dn | Down-regulated in human hepatoma cells (HepG2) following 24 hrs treatment with 2.5 microM 5-aza-2-deoxycytidine (5azaC) and 24 hrs treatment with both 5azaC and 500 nM trichostatin A (TSA). | 2343 | 5.79 | 13 | 2.24 | 6.65e-03 |
| p21_any_dn | Down-regulated at any timepoint (4-24 hrs) follwing ectopic expression of p21 (CDKN1A) in OvCa cells | 50 | 0.12 | 2 | 16.18 | 6.92e-03 |
| et743_sarcoma_48hrs_dn | Down-regulated at48 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines | 304 | 0.75 | 4 | 5.32 | 7.25e-03 |
| uvc_high_d9_dn | Progressively down-regulated through 24 hrs following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (cluster d9) | 53 | 0.13 | 2 | 15.27 | 7.74e-03 |
| rcc_nl_up | Upregulated in VHL-rescued renal carcinoma vs. normal renal cells (Fig. 2d+e) | 899 | 2.22 | 7 | 3.15 | 7.77e-03 |
| uvc_xpcs_8hr_dn | Down-regulated at 8 hours following treatment of XPB/CS fibroblasts with 3 J/m^2 UVC | 911 | 2.25 | 7 | 3.11 | 8.32e-03 |
| hippocampus_development_prenatal | Highly expressed in prenatal mouse hippocampus (cluster 1) | 58 | 0.14 | 2 | 13.95 | 9.21e-03 |
| cmv_hcmv_timecourse_20hrs_up | Up-regulated in fibroblasts following infection with human cytomegalovirus (at least 3-fold, with Affymetrix change call, in at least two consectutive timepoints), with maximum change at 20 hours | 174 | 0.43 | 3 | 6.97 | 9.52e-03 |