#list name reference description total probes expected actual enrichment bin prob analysis_name mannosyltransferase activity GO:0000030 Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid. 9 0.0222474909774064 0 0 1 C01D.profile.u50 tRNA binding GO:0000049 Interacting selectively with transfer RNA. 20 0.049438868838681 0 0 1 C01D.profile.u50 acyl-CoA binding GO:0000062 Interacting selectively with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group. 13 0.0321352647451426 0 0 1 C01D.profile.u50 microfilament motor activity GO:0000146 Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). 23 0.0568546991644831 0 0 1 C01D.profile.u50 SNARE binding GO:0000149 Interacting selectively with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein. 20 0.049438868838681 0 0 1 C01D.profile.u50 two-component sensor activity GO:0000155 Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell. 6 0.0148316606516043 0 0 1 C01D.profile.u50 nucleotide binding GO:0000166 Interacting selectively with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety. 2671 6.60256093340584 8 1.2116510670161 0.342222548128125 C01D.profile.u50 3'-5'-exoribonuclease activity GO:0000175 Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. 14 0.0346072081870767 0 0 1 C01D.profile.u50 magnesium ion binding GO:0000287 Interacting selectively with magnesium (Mg) ions. 436 1.07776734068325 2 1.8556880733945 0.292857531835256 C01D.profile.u50 RNA cap binding GO:0000339 Interacting selectively with a 7-methylguanosine (m7G) moiety or derivative located at the 5' end of an RNA molecule. 16 0.0395510950709448 0 0 1 C01D.profile.u50 beta-amyloid binding GO:0001540 Interacting selectively with beta-amyloid peptide/protein and/or its precursor. 19 0.0469669253967469 0 0 1 C01D.profile.u50 phorbol ester receptor activity GO:0001565 Combining with a phorbol ester to initiate a change in cell activity. 19 0.0469669253967469 0 0 1 C01D.profile.u50 rhodopsin-like receptor activity GO:0001584 A G-protein coupled receptor that is structurally/functionally related to the rhodopsin receptor. 405 1.00113709398329 0 0 1 C01D.profile.u50 angiotensin receptor activity GO:0001595 Combining with angiotensin to initiate a change in cell activity. 11 0.0271913778612745 0 0 1 C01D.profile.u50 nucleotide receptor activity, G-protein coupled GO:0001608 A GPCR that binds a nucleotide or nucleotide derivative as its ligand. 22 0.0543827557225491 0 0 1 C01D.profile.u50 purinergic nucleotide receptor activity GO:0001614 22 0.0543827557225491 0 0 1 C01D.profile.u50 lysosphingolipid and lysophosphatidic acid receptor activity GO:0001619 Combining with lysosphingolipid or lysophosphatidic acid to initiate a change in cell activity. 12 0.0296633213032086 0 0 1 C01D.profile.u50 secretin-like receptor activity GO:0001633 A G-protein coupled receptor that is structurally/functionally related to the secretin receptor. 37 0.0914619073515598 0 0 1 C01D.profile.u50 G-protein chemoattractant receptor activity GO:0001637 33 0.0815741335838236 0 0 1 C01D.profile.u50 peptide receptor activity GO:0001653 Combining with an extracellular or intracellular peptide to initiate a change in cell activity. 142 0.351015968754635 0 0 1 C01D.profile.u50 G-protein-coupled receptor binding GO:0001664 Interacting selectively with a G-protein-coupled receptor. 78 0.192811588470856 0 0 1 C01D.profile.u50 lipid kinase activity GO:0001727 Catalysis of the phosphorylation of a simple or complex lipid. 29 0.0716863598160874 0 0 1 C01D.profile.u50 phosphatidylserine binding GO:0001786 Interacting selectively with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine. 8 0.0197755475354724 0 0 1 C01D.profile.u50 pattern binding GO:0001871 Interacting selectively with a repeating or polymeric structure, such as a polysaccharide or peptidoglycan. 186 0.459781480199733 0 0 1 C01D.profile.u50 glycoprotein binding GO:0001948 Interacting selectively with a glycoprotein, a protein that contains covalently bound glycose (monosaccharide) residues. These also include proteoglycans. 10 0.0247194344193405 0 0 1 C01D.profile.u50 nucleic acid binding GO:0003676 Interacting selectively with any nucleic acid. 3764 9.30439511543976 12 1.28971307120085 0.227265181777277 C01D.profile.u50 DNA binding GO:0003677 Interacting selectively with DNA (deoxyribonucleic acid). 2546 6.29356800316409 10 1.58892380204242 0.105348124367069 C01D.profile.u50 DNA helicase activity GO:0003678 Catalysis of the hydrolysis of an NTP or dNTP to unwind the DNA helix. 55 0.135956889306373 1 7.35527272727273 0.127266645466854 C01D.profile.u50 chromatin binding GO:0003682 Interacting selectively with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase. 162 0.400454837593316 1 2.49716049382716 0.330316861198002 C01D.profile.u50 damaged DNA binding GO:0003684 Interacting selectively with damaged DNA. 56 0.138428832748307 0 0 1 C01D.profile.u50 double-stranded DNA binding GO:0003690 Interacting selectively with double-stranded DNA. 88 0.217531022890196 0 0 1 C01D.profile.u50 single-stranded DNA binding GO:0003697 Interacting selectively with single-stranded DNA. 72 0.177979927819252 0 0 1 C01D.profile.u50 transcription factor activity GO:0003700 The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. 1230 3.04049043357888 6 1.97336585365854 0.0878039769641209 C01D.profile.u50 RNA polymerase II transcription factor activity GO:0003702 Functions to initiate or regulate RNA polymerase II transcription. 356 0.880011865328521 1 1.13634831460674 0.585673650087225 C01D.profile.u50 specific RNA polymerase II transcription factor activity GO:0003704 Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II. 63 0.155732436841845 0 0 1 C01D.profile.u50 RNA polymerase II transcription factor activity, enhancer binding GO:0003705 Functions to initiate or regulate RNA polymerase II transcription by binding an enhancer region of DNA. 40 0.098877737677362 0 0 1 C01D.profile.u50 ligand-regulated transcription factor activity GO:0003706 21 0.051910812280615 0 0 1 C01D.profile.u50 steroid hormone receptor activity GO:0003707 Combining with a steroid hormone to initiate a change in cell activity. 118 0.291689326148218 1 3.42830508474576 0.2532691309279 C01D.profile.u50 retinoic acid receptor activity GO:0003708 Combining with retinoic acid to initiate a change in cell activity. Retinoic acid is one of the forms of vitamin A. 18 0.0444949819548129 0 0 1 C01D.profile.u50 RNA polymerase III transcription factor activity GO:0003709 Functions to initiate or regulate RNA polymerase III transcription. 18 0.0444949819548129 0 0 1 C01D.profile.u50 transcriptional elongation regulator activity GO:0003711 Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation. 23 0.0568546991644831 0 0 1 C01D.profile.u50 transcription cofactor activity GO:0003712 The function that links a sequence-specific transcription factor to the core RNA polymerase II complex but does not bind DNA itself. 482 1.19147673901221 1 0.839294605809129 0.69667541278654 C01D.profile.u50 transcription coactivator activity GO:0003713 The function of a transcription cofactor that activates transcription from a RNA polymerase II promoter; does not bind DNA itself. 295 0.729223315370544 0 0 1 C01D.profile.u50 transcription corepressor activity GO:0003714 The function of a transcription cofactor that represses transcription from a RNA polymerase II promoter; does not bind DNA itself. 169 0.417758441686854 0 0 1 C01D.profile.u50 RNA binding GO:0003723 Interacting selectively with an RNA molecule or a portion thereof. 982 2.42744845997924 3 1.23586558044807 0.4375834790738 C01D.profile.u50 RNA helicase activity GO:0003724 Catalysis of the unwinding of an RNA helix. 50 0.123597172096702 0 0 1 C01D.profile.u50 double-stranded RNA binding GO:0003725 Interacting selectively with double-stranded RNA. 58 0.143372719632175 1 6.9748275862069 0.133722702603265 C01D.profile.u50 single-stranded RNA binding GO:0003727 Interacting selectively with single-stranded RNA. 24 0.0593266426064172 1 16.8558333333333 0.0576703226918033 C01D.profile.u50 mRNA binding GO:0003729 Interacting selectively with pre-messenger RNA (pre-mRNA) or messenger RNA (mRNA). 74 0.18292381470312 1 5.46675675675676 0.167356980462907 C01D.profile.u50 mRNA 3'-UTR binding GO:0003730 Interacting selectively with the 3' untranslated region of an mRNA molecule. 16 0.0395510950709448 0 0 1 C01D.profile.u50 structural constituent of ribosome GO:0003735 The action of a molecule that contributes to the structural integrity of the ribosome. 219 0.541355613783557 0 0 1 C01D.profile.u50 translation initiation factor activity GO:0003743 Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. 75 0.185395758145054 0 0 1 C01D.profile.u50 translation elongation factor activity GO:0003746 Functions in chain elongation during polypeptide synthesis at the ribosome. 19 0.0469669253967469 0 0 1 C01D.profile.u50 translation release factor activity GO:0003747 Involved in catalyzing the release of a nascent polypeptide chain from a ribosome. 9 0.0222474909774064 0 0 1 C01D.profile.u50 peptidyl-prolyl cis-trans isomerase activity GO:0003755 Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). 57 0.140900776190241 0 0 1 C01D.profile.u50 protein disulfide isomerase activity GO:0003756 Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins. 17 0.0420230385128788 1 23.7964705882353 0.0412021928988779 C01D.profile.u50 motor activity GO:0003774 Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate. 168 0.41528649824492 0 0 1 C01D.profile.u50 microtubule motor activity GO:0003777 Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP). 76 0.187867701586988 0 0 1 C01D.profile.u50 actin binding GO:0003779 Interacting selectively with monomeric or multimeric forms of actin, including actin filaments. 398 0.983833489889751 0 0 1 C01D.profile.u50 lysozyme activity GO:0003796 Catalysis of the hydrolysis of the 1,4-beta-linkages between N-acetyl-D-glucosamine and N-acetylmuramic acid in peptidoglycan heteropolymers of the prokaryotes cell walls and between N-acetyl-D-glucosamine residues in chitodextrins. 3 0.00741583032580215 0 0 1 C01D.profile.u50 protein-glutamine gamma-glutamyltransferase activity GO:0003810 Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links. 11 0.0271913778612745 0 0 1 C01D.profile.u50 antigen binding GO:0003823 Interacting selectively with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen. 91 0.224946853215998 0 0 1 C01D.profile.u50 catalytic activity GO:0003824 Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. 6002 14.8366045384882 15 1.01101299566811 0.517629074453955 C01D.profile.u50 gamma-glutamyltransferase activity GO:0003840 Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid. 7 0.0173036040935383 0 0 1 C01D.profile.u50 1-acylglycerol-3-phosphate O-acyltransferase activity GO:0003841 Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate. 10 0.0247194344193405 0 0 1 C01D.profile.u50 3-beta-hydroxy-delta5-steroid dehydrogenase activity GO:0003854 Catalysis of the reaction: 3-beta-hydroxy-delta(5)-steroid + NAD+ = 3-oxo-delta(5)-steroid + NADH + H+. 4 0.00988777376773619 0 0 1 C01D.profile.u50 3-hydroxyacyl-CoA dehydrogenase activity GO:0003857 Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+. 10 0.0247194344193405 0 0 1 C01D.profile.u50 DNA-directed DNA polymerase activity GO:0003887 Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template or primer. 27 0.0667424729322193 0 0 1 C01D.profile.u50 DNA-directed RNA polymerase activity GO:0003899 Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. 45 0.111237454887032 0 0 1 C01D.profile.u50 DNA-(apurinic or apyrimidinic site) lyase activity GO:0003906 Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. 7 0.0173036040935383 0 0 1 C01D.profile.u50 DNA topoisomerase activity GO:0003916 Catalysis of a topological transformation in double-stranded DNA by a covalent or non-covalent mechanism. 12 0.0296633213032086 0 0 1 C01D.profile.u50 GTPase activity GO:0003924 Catalysis of the reaction: GTP + H2O = GDP + phosphate. 299 0.739111089138281 0 0 1 C01D.profile.u50 NAD+ ADP-ribosyltransferase activity GO:0003950 Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. 27 0.0667424729322193 0 0 1 C01D.profile.u50 NADH dehydrogenase activity GO:0003954 Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor. 39 0.0964057942354279 0 0 1 C01D.profile.u50 RNA-directed DNA polymerase activity GO:0003964 Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. 7 0.0173036040935383 0 0 1 C01D.profile.u50 acid phosphatase activity GO:0003993 Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. 12 0.0296633213032086 0 0 1 C01D.profile.u50 aconitate hydratase activity GO:0003994 Catalysis of the reaction: citrate = cis-aconitate + H2O = isocitrate; i.e. the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate. 3 0.00741583032580215 0 0 1 C01D.profile.u50 acyl-CoA dehydrogenase activity GO:0003995 Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. 26 0.0642705294902853 1 15.5592307692308 0.0623233359141062 C01D.profile.u50 adenosine deaminase activity GO:0004000 Catalysis of the reaction: adenosine + H2O = inosine + NH3. 9 0.0222474909774064 0 0 1 C01D.profile.u50 ATP-dependent DNA helicase activity GO:0004003 Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of the DNA helix. 34 0.0840460770257577 1 11.8982352941176 0.0807067650980794 C01D.profile.u50 ATP-dependent RNA helicase activity GO:0004004 Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of an RNA helix. 35 0.0865180204676917 0 0 1 C01D.profile.u50 phospholipid-translocating ATPase activity GO:0004012 Catalysis of the movement of phospholipids from one membrane face to the other ('flippase' activity), driven by the hydrolysis of ATP. 21 0.051910812280615 0 0 1 C01D.profile.u50 adenylate cyclase activity GO:0004016 Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. 18 0.0444949819548129 0 0 1 C01D.profile.u50 adenylate kinase activity GO:0004017 Catalysis of the reaction: ATP + AMP = 2 ADP. 12 0.0296633213032086 0 0 1 C01D.profile.u50 alcohol dehydrogenase activity GO:0004022 Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. 10 0.0247194344193405 0 0 1 C01D.profile.u50 3-chloroallyl aldehyde dehydrogenase activity GO:0004028 Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid. 12 0.0296633213032086 0 0 1 C01D.profile.u50 aldehyde dehydrogenase (NAD) activity GO:0004029 Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+. 14 0.0346072081870767 0 0 1 C01D.profile.u50 aldehyde dehydrogenase [NAD(P)+] activity GO:0004030 Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+. 10 0.0247194344193405 0 0 1 C01D.profile.u50 aldo-keto reductase activity GO:0004033 Catalysis of the NADPH-dependent reduction of carbonyl compounds. 12 0.0296633213032086 0 0 1 C01D.profile.u50 amidase activity GO:0004040 Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3. 4 0.00988777376773619 0 0 1 C01D.profile.u50 aminomethyltransferase activity GO:0004047 Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein. 7 0.0173036040935383 0 0 1 C01D.profile.u50 arylsulfatase activity GO:0004065 Catalysis of the reaction: a phenol sulfate + H2O = a phenol + SO4(2-) (sulfate). 10 0.0247194344193405 0 0 1 C01D.profile.u50 carbonate dehydratase activity GO:0004089 Catalysis of the reaction: H2CO3 = CO2 + H2O. 24 0.0593266426064172 0 0 1 C01D.profile.u50 carboxylesterase activity GO:0004091 Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion. 118 0.291689326148218 0 0 1 C01D.profile.u50 cyclic-nucleotide phosphodiesterase activity GO:0004112 Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate. 41 0.101349681119296 0 0 1 C01D.profile.u50 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0004114 Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate. 40 0.098877737677362 0 0 1 C01D.profile.u50 3',5'-cyclic-AMP phosphodiesterase activity GO:0004115 Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. 17 0.0420230385128788 0 0 1 C01D.profile.u50 cytochrome-b5 reductase activity GO:0004128 Catalysis of the reaction: NADH + H+ + 2 ferricytochrome b(5) = NAD+ + 2 ferrocytochrome b(5). 12 0.0296633213032086 0 0 1 C01D.profile.u50 cytochrome-c oxidase activity GO:0004129 Catalysis of the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O. 36 0.0889899639096258 0 0 1 C01D.profile.u50 diacylglycerol kinase activity GO:0004143 Catalysis of the reaction: ATP + 1,2-diacylglycerol = ADP + 1,2-diacylglycerol 3-phosphate. 15 0.0370791516290107 0 0 1 C01D.profile.u50 endopeptidase activity GO:0004175 Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides, and comprising any enzyme of sub-subclasses EC:3.4.21-99. They are classfied according to the presence of essential catalytic residues or ions at their active sites. 432 1.06787956691551 0 0 1 C01D.profile.u50 ATP-dependent peptidase activity GO:0004176 3 0.00741583032580215 0 0 1 C01D.profile.u50 aminopeptidase activity GO:0004177 Catalysis of the hydrolysis of N-terminal amino acid residues from oligopeptides or polypeptides. 47 0.1161813417709 0 0 1 C01D.profile.u50 membrane alanyl aminopeptidase activity GO:0004179 Catalysis of the release of an N-terminal amino acid, Xaa-Xbb- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide. 13 0.0321352647451426 0 0 1 C01D.profile.u50 carboxypeptidase activity GO:0004180 Catalysis of the hydrolytic cleavage of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide. 40 0.098877737677362 0 0 1 C01D.profile.u50 metallocarboxypeptidase activity GO:0004181 Catalysis of the hydrolysis of C-terminal amino acid residues from oligopeptides or polypeptides; a bivalent cation is an essential component of the catalytic mechanism. 31 0.0766302466999555 0 0 1 C01D.profile.u50 carboxypeptidase A activity GO:0004182 Catalysis of the reaction: peptidyl-L-amino acid + H2O = peptide + L-amino acid. Little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. 22 0.0543827557225491 0 0 1 C01D.profile.u50 aspartic-type endopeptidase activity GO:0004190 Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process. 9 0.0222474909774064 0 0 1 C01D.profile.u50 pepsin A activity GO:0004194 Catalysis of the hydrolysis of peptide bonds. Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe1-Val2, Gln4-His5, Glu13-Ala14, Ala14-Leu15, Leu15-Tyr16, Tyr16-Leu17, Gly23-Phe24, Phe24-Phe25 and Phe25-Tyr26 bonds in the B chain of insulin. 6 0.0148316606516043 0 0 1 C01D.profile.u50 cysteine-type endopeptidase activity GO:0004197 Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center. 105 0.259554061403075 0 0 1 C01D.profile.u50 calpain activity GO:0004198 Catalysis of the preferential cleavage of Tyr-Xaa, Met-Xaa or Arg-Xaa with Leu or Val as the P2 residue. 20 0.049438868838681 0 0 1 C01D.profile.u50 ubiquitin thiolesterase activity GO:0004221 Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin. 74 0.18292381470312 0 0 1 C01D.profile.u50 metalloendopeptidase activity GO:0004222 Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites. 125 0.308992930241756 0 0 1 C01D.profile.u50 neprilysin activity GO:0004245 Catalysis of the preferential cleavage at the amino group of hydrophobic residues in insulin, casein, hemoglobin, and a number of other proteins and polypeptides. 8 0.0197755475354724 0 0 1 C01D.profile.u50 serine-type endopeptidase activity GO:0004252 Catalysis of the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). 165 0.407870667919118 0 0 1 C01D.profile.u50 dipeptidyl-peptidase IV activity GO:0004274 Catalysis of the release of an N-terminal dipeptide, by the hydrolysis of the Xbb-Xcc bond in Xaa-Xbb-Xcc, preferentially when Xbb is Pro, provided Xcc is neither Pro nor hydroxyproline. 7 0.0173036040935383 0 0 1 C01D.profile.u50 subtilase activity GO:0004289 16 0.0395510950709448 0 0 1 C01D.profile.u50 threonine endopeptidase activity GO:0004298 Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a reaction mechanism in which threonine residues act as nucleophiles. 26 0.0642705294902853 0 0 1 C01D.profile.u50 enoyl-CoA hydratase activity GO:0004300 Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O. 8 0.0197755475354724 0 0 1 C01D.profile.u50 estradiol 17-beta-dehydrogenase activity GO:0004303 Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+. 8 0.0197755475354724 0 0 1 C01D.profile.u50 exo-alpha-sialidase activity GO:0004308 Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. 5 0.0123597172096702 0 0 1 C01D.profile.u50 fructose-2,6-bisphosphate 2-phosphatase activity GO:0004331 Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. 7 0.0173036040935383 0 0 1 C01D.profile.u50 glucan 1,4-alpha-glucosidase activity GO:0004339 Catalysis of the hydrolysis of terminal 1,4-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose. 3 0.00741583032580215 0 0 1 C01D.profile.u50 glutathione transferase activity GO:0004364 Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. 19 0.0469669253967469 0 0 1 C01D.profile.u50 glycine hydroxymethyltransferase activity GO:0004372 Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. 14 0.0346072081870767 0 0 1 C01D.profile.u50 guanylate cyclase activity GO:0004383 Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate. 12 0.0296633213032086 0 0 1 C01D.profile.u50 guanylate kinase activity GO:0004385 Catalysis of the reaction: ATP + GMP = ADP + GDP. 19 0.0469669253967469 0 0 1 C01D.profile.u50 helicase activity GO:0004386 Catalysis of the unwinding of a DNA or RNA duplex. 206 0.509220349038414 1 1.96378640776699 0.399414802614256 C01D.profile.u50 histone acetyltransferase activity GO:0004402 Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone. 42 0.10382162456123 0 0 1 C01D.profile.u50 histone deacetylase activity GO:0004407 Catalysis of the hydrolysis of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes. 14 0.0346072081870767 0 0 1 C01D.profile.u50 hyalurononglucosaminidase activity GO:0004415 Catalysis of the random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. 10 0.0247194344193405 0 0 1 C01D.profile.u50 inositol or phosphatidylinositol kinase activity GO:0004428 Catalysis of the phosphorylation of myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. 34 0.0840460770257577 0 0 1 C01D.profile.u50 inositol or phosphatidylinositol phosphodiesterase activity GO:0004434 34 0.0840460770257577 0 0 1 C01D.profile.u50 phosphoinositide phospholipase C activity GO:0004435 Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. 34 0.0840460770257577 0 0 1 C01D.profile.u50 inositol or phosphatidylinositol phosphatase activity GO:0004437 Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol. 58 0.143372719632175 0 0 1 C01D.profile.u50 inositol-polyphosphate 5-phosphatase activity GO:0004445 Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate. 9 0.0222474909774064 0 0 1 C01D.profile.u50 lactate dehydrogenase activity GO:0004457 Catalysis of the oxidation of lactate to produce pyruvate. 9 0.0222474909774064 0 0 1 C01D.profile.u50 L-lactate dehydrogenase activity GO:0004459 Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+. 9 0.0222474909774064 0 0 1 C01D.profile.u50 long-chain-fatty-acid-CoA ligase activity GO:0004467 Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; long-chain fatty acids have chain lengths of C12-18. 16 0.0395510950709448 0 0 1 C01D.profile.u50 lysine N-acetyltransferase activity GO:0004468 Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine. 42 0.10382162456123 0 0 1 C01D.profile.u50 monooxygenase activity GO:0004497 Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. 133 0.328768477777228 1 3.04165413533835 0.280483267512633 C01D.profile.u50 dimethylaniline monooxygenase (N-oxide-forming) activity GO:0004499 Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. 8 0.0197755475354724 0 0 1 C01D.profile.u50 nuclease activity GO:0004518 Catalysis of the hydrolysis of ester linkages within nucleic acids. 161 0.397982894151382 0 0 1 C01D.profile.u50 endonuclease activity GO:0004519 Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. 99 0.244722400751471 0 0 1 C01D.profile.u50 endodeoxyribonuclease activity GO:0004520 Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks. 22 0.0543827557225491 0 0 1 C01D.profile.u50 endoribonuclease activity GO:0004521 Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks. 48 0.118653285212834 0 0 1 C01D.profile.u50 pancreatic ribonuclease activity GO:0004522 Catalysis of the endonucleolytic cleavage of RNA to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates. 12 0.0296633213032086 0 0 1 C01D.profile.u50 ribonuclease H activity GO:0004523 Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters. 8 0.0197755475354724 0 0 1 C01D.profile.u50 ribonuclease P activity GO:0004526 Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor. 10 0.0247194344193405 0 0 1 C01D.profile.u50 exonuclease activity GO:0004527 Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. 61 0.150788549957977 0 0 1 C01D.profile.u50 exodeoxyribonuclease activity GO:0004529 Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule. 12 0.0296633213032086 0 0 1 C01D.profile.u50 exoribonuclease activity GO:0004532 Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule. 15 0.0370791516290107 0 0 1 C01D.profile.u50 deoxyribonuclease activity GO:0004536 Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid. 39 0.0964057942354279 0 0 1 C01D.profile.u50 ribonuclease activity GO:0004540 Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. 67 0.165620210609581 0 0 1 C01D.profile.u50 tRNA-specific ribonuclease activity GO:0004549 Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules. 13 0.0321352647451426 0 0 1 C01D.profile.u50 nucleoside diphosphate kinase activity GO:0004550 Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. 9 0.0222474909774064 0 0 1 C01D.profile.u50 nucleotide diphosphatase activity GO:0004551 Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides. 6 0.0148316606516043 0 0 1 C01D.profile.u50 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0004553 Catalysis of the hydrolysis of any O-glycosyl bond. 103 0.254610174519207 0 0 1 C01D.profile.u50 alpha-mannosidase activity GO:0004559 Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. 7 0.0173036040935383 0 0 1 C01D.profile.u50 beta-galactosidase activity GO:0004565 Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides. 6 0.0148316606516043 0 0 1 C01D.profile.u50 chitinase activity GO:0004568 Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins. 10 0.0247194344193405 0 0 1 C01D.profile.u50 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity GO:0004571 Catalysis of the hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2). 14 0.0346072081870767 0 0 1 C01D.profile.u50 oligosaccharyl transferase activity GO:0004576 Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid. 13 0.0321352647451426 0 0 1 C01D.profile.u50 dolichyl-diphosphooligosaccharide-protein glycotransferase activity GO:0004579 Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine. 11 0.0271913778612745 0 0 1 C01D.profile.u50 peroxidase activity GO:0004601 Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O. 39 0.0964057942354279 0 0 1 C01D.profile.u50 glutathione peroxidase activity GO:0004602 Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O. 9 0.0222474909774064 0 0 1 C01D.profile.u50 phospholipase activity GO:0004620 Catalysis of the hydrolysis of a glycerophospholipid. 79 0.19528353191279 0 0 1 C01D.profile.u50 lysophospholipase activity GO:0004622 Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate. 10 0.0247194344193405 0 0 1 C01D.profile.u50 phospholipase A2 activity GO:0004623 Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. 25 0.0617985860483512 0 0 1 C01D.profile.u50 phospholipase C activity GO:0004629 Catalysis of the reaction: a phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate. 38 0.0939338507934939 0 0 1 C01D.profile.u50 polypeptide N-acetylgalactosaminyltransferase activity GO:0004653 Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. Catalyzes of the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis. 17 0.0420230385128788 0 0 1 C01D.profile.u50 prenyltransferase activity GO:0004659 Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). 19 0.0469669253967469 0 0 1 C01D.profile.u50 protein geranylgeranyltransferase activity GO:0004661 Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein. 9 0.0222474909774064 0 0 1 C01D.profile.u50 protein kinase activity GO:0004672 Catalysis of the transfer of a phosphate group, usually from ATP, to a protein substrate. 869 2.14811885104069 1 0.465523590333717 0.883606460602707 C01D.profile.u50 protein histidine kinase activity GO:0004673 Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine. 14 0.0346072081870767 0 0 1 C01D.profile.u50 protein serine/threonine kinase activity GO:0004674 Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate. 618 1.52766104711524 0 0 1 C01D.profile.u50 transmembrane receptor protein serine/threonine kinase activity GO:0004675 24 0.0593266426064172 0 0 1 C01D.profile.u50 casein kinase activity GO:0004680 18 0.0444949819548129 0 0 1 C01D.profile.u50 cyclic nucleotide-dependent protein kinase activity GO:0004690 Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the presence of a cyclic nucleotide. 11 0.0271913778612745 0 0 1 C01D.profile.u50 cAMP-dependent protein kinase activity GO:0004691 Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the presence of cAMP. 8 0.0197755475354724 0 0 1 C01D.profile.u50 cyclin-dependent protein kinase activity GO:0004693 Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK). 16 0.0395510950709448 0 0 1 C01D.profile.u50 protein kinase C activity GO:0004697 19 0.0469669253967469 0 0 1 C01D.profile.u50 receptor signaling protein serine/threonine kinase activity GO:0004702 78 0.192811588470856 0 0 1 C01D.profile.u50 G-protein coupled receptor kinase activity GO:0004703 Catalysis of the phosphorylation of a G-protein coupled receptor, thereby modulating its activity. 12 0.0296633213032086 0 0 1 C01D.profile.u50 MAP kinase activity GO:0004707 Catalysis of the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. 24 0.0593266426064172 0 0 1 C01D.profile.u50 MAP kinase kinase activity GO:0004708 Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in MAP kinases. It is a dual-specificity mitogen-activated protein kinase kinase and requires activation by the serine/threonine kinase, MAP kinase kinase kinase. 19 0.0469669253967469 0 0 1 C01D.profile.u50 MAP kinase kinase kinase activity GO:0004709 Catalysis of the phosphorylation and activation of MAP kinase kinases; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases. 22 0.0543827557225491 0 0 1 C01D.profile.u50 protein threonine/tyrosine kinase activity GO:0004712 20 0.049438868838681 0 0 1 C01D.profile.u50 protein-tyrosine kinase activity GO:0004713 Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. 299 0.739111089138281 1 1.35297658862876 0.522898545475786 C01D.profile.u50 transmembrane receptor protein tyrosine kinase activity GO:0004714 139 0.343600138428833 1 2.91035971223022 0.291089163330703 C01D.profile.u50 non-membrane spanning protein tyrosine kinase activity GO:0004715 25 0.0617985860483512 0 0 1 C01D.profile.u50 receptor signaling protein tyrosine kinase activity GO:0004716 22 0.0543827557225491 0 0 1 C01D.profile.u50 protein-lysine 6-oxidase activity GO:0004720 Catalysis of the reaction: peptidyl-L-lysyl-peptide + H2O + O2 = peptidyl-allysyl-peptide + NH3 + H2O2. 7 0.0173036040935383 0 0 1 C01D.profile.u50 phosphoprotein phosphatase activity GO:0004721 Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity. 236 0.583378652296435 0 0 1 C01D.profile.u50 protein serine/threonine phosphatase activity GO:0004722 Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. 71 0.175507984377317 0 0 1 C01D.profile.u50 protein tyrosine phosphatase activity GO:0004725 Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. 150 0.370791516290107 0 0 1 C01D.profile.u50 non-membrane spanning protein tyrosine phosphatase activity GO:0004726 18 0.0444949819548129 0 0 1 C01D.profile.u50 pseudouridylate synthase activity GO:0004730 Catalysis of the reaction: uracil + D-ribose 5-phosphate = pseudouridine 5'-phosphate + H2O. 5 0.0123597172096702 0 0 1 C01D.profile.u50 retinol dehydrogenase activity GO:0004745 Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+. 8 0.0197755475354724 0 0 1 C01D.profile.u50 sphingomyelin phosphodiesterase activity GO:0004767 Catalysis of the reaction: sphingomyelin + H2O = N-acylsphingosine + choline phosphate. 8 0.0197755475354724 0 0 1 C01D.profile.u50 steroid delta-isomerase activity GO:0004769 Catalysis of the reaction: a 3-oxo-delta(5)-steroid = a 3-oxo-delta(4)-steroid. 6 0.0148316606516043 0 0 1 C01D.profile.u50 triacylglycerol lipase activity GO:0004806 Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion. 11 0.0271913778612745 0 0 1 C01D.profile.u50 aminoacyl-tRNA ligase activity GO:0004812 Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP. 54 0.133484945864439 0 0 1 C01D.profile.u50 tubulin-tyrosine ligase activity GO:0004835 Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate. 11 0.0271913778612745 0 0 1 C01D.profile.u50 ubiquitin-protein ligase activity GO:0004842 Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. 175 0.432590102338459 0 0 1 C01D.profile.u50 ubiquitin-specific protease activity GO:0004843 Catalysis of the hydrolysis of various forms of polymeric ubiquitin sequences. Will remove ubiquitin from larger leaving groups. 79 0.19528353191279 0 0 1 C01D.profile.u50 enzyme inhibitor activity GO:0004857 Stops, prevents or reduces the activity of an enzyme. 333 0.823157166164038 0 0 1 C01D.profile.u50 phospholipase inhibitor activity GO:0004859 Stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid. 11 0.0271913778612745 0 0 1 C01D.profile.u50 protein kinase inhibitor activity GO:0004860 Stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein. 58 0.143372719632175 0 0 1 C01D.profile.u50 cyclin-dependent protein kinase inhibitor activity GO:0004861 Stops, prevents or reduces the activity of a cyclin-dependent protein kinase. 19 0.0469669253967469 0 0 1 C01D.profile.u50 protein phosphatase inhibitor activity GO:0004864 Stops, prevents or reduces the activity of a protein phosphatase, an enzyme that hydrolyzes phosphate groups from proteins. 34 0.0840460770257577 0 0 1 C01D.profile.u50 type 1 serine/threonine specific protein phosphatase inhibitor activity GO:0004865 7 0.0173036040935383 0 0 1 C01D.profile.u50 endopeptidase inhibitor activity GO:0004866 Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide linkages in polypeptides. 156 0.385623176941712 0 0 1 C01D.profile.u50 serine-type endopeptidase inhibitor activity GO:0004867 Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides; a serine residue (and a histidine residue) are at the active center of the enzyme. 98 0.242250457309537 0 0 1 C01D.profile.u50 cysteine protease inhibitor activity GO:0004869 28 0.0692144163741534 0 0 1 C01D.profile.u50 signal transducer activity GO:0004871 Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell. 2506 6.19469026548673 6 0.968571428571428 0.58529320483864 C01D.profile.u50 receptor activity GO:0004872 Combining with an extracellular or intracellular messenger to initiate a change in cell activity. 1863 4.60523063232313 5 1.0857219538379 0.487886902688481 C01D.profile.u50 ligand-dependent nuclear receptor activity GO:0004879 A ligand-dependent receptor found in the nucleus of the cell. 131 0.32382459089336 1 3.08809160305344 0.276912824738315 C01D.profile.u50 thyroid hormone receptor activity GO:0004887 Combining with thyroid hormone to initiate a change in cell activity. 15 0.0370791516290107 0 0 1 C01D.profile.u50 transmembrane receptor activity GO:0004888 Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle. 1150 2.84273495822416 3 1.05532173913043 0.54091610373927 C01D.profile.u50 nicotinic acetylcholine-activated cation-selective channel activity GO:0004889 23 0.0568546991644831 0 0 1 C01D.profile.u50 GABA-A receptor activity GO:0004890 Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels. 22 0.0543827557225491 1 18.3881818181818 0.0529942199196842 C01D.profile.u50 hematopoietin/interferon-class (D200-domain) cytokine receptor activity GO:0004896 90 0.222474909774064 0 0 1 C01D.profile.u50 interleukin receptor activity GO:0004907 Combining with an interleukin to initiate a change in cell activity. 46 0.113709398328966 0 0 1 C01D.profile.u50 interleukin-1 receptor activity GO:0004908 Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response. 11 0.0271913778612745 0 0 1 C01D.profile.u50 non-G-protein coupled 7TM receptor activity GO:0004926 14 0.0346072081870767 0 0 1 C01D.profile.u50 G-protein coupled receptor activity GO:0004930 A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers. 515 1.27305087259603 0 0 1 C01D.profile.u50 adrenoceptor activity GO:0004935 17 0.0420230385128788 0 0 1 C01D.profile.u50 alpha-adrenergic receptor activity GO:0004936 10 0.0247194344193405 0 0 1 C01D.profile.u50 angiotensin type II receptor activity GO:0004945 11 0.0271913778612745 0 0 1 C01D.profile.u50 chemokine receptor activity GO:0004950 Combining with chemokines, small chemoattractant molecules normally used to stimulate leukocytes, to initiate a change in cell activity. 33 0.0815741335838236 0 0 1 C01D.profile.u50 dopamine receptor activity GO:0004952 Combining with the neurotransmitter dopamine to initiate a change in cell activity. 9 0.0222474909774064 0 0 1 C01D.profile.u50 icosanoid receptor activity GO:0004953 Combining with an icosanoid to initiate a change in cell activity. 33 0.0815741335838236 0 0 1 C01D.profile.u50 prostanoid receptor activity GO:0004954 Combining with a prostanoid, any compound based on or derive4d from the prostanoate structure, to initiate a change in cell activity. 33 0.0815741335838236 0 0 1 C01D.profile.u50 prostaglandin receptor activity GO:0004955 Combining with a prostaglandin (PG) to initiate a change in cell activity. 28 0.0692144163741534 0 0 1 C01D.profile.u50 prostaglandin E receptor activity GO:0004957 Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity. 20 0.049438868838681 0 0 1 C01D.profile.u50 histamine receptor activity GO:0004969 Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. 9 0.0222474909774064 0 0 1 C01D.profile.u50 ionotropic glutamate receptor activity GO:0004970 Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. 26 0.0642705294902853 0 0 1 C01D.profile.u50 melanocortin receptor activity GO:0004977 Combining with melanocortin to initiate a change in cell activity. 9 0.0222474909774064 0 0 1 C01D.profile.u50 muscarinic acetylcholine receptor activity GO:0004981 5 0.0123597172096702 0 0 1 C01D.profile.u50 N-formyl peptide receptor activity GO:0004982 Combining with an N-formyl peptide to initiate a change in cell activity. 9 0.0222474909774064 0 0 1 C01D.profile.u50 neuropeptide Y receptor activity GO:0004983 Combining with neuropeptide Y to initiate a change in cell activity. 7 0.0173036040935383 0 0 1 C01D.profile.u50 olfactory receptor activity GO:0004984 Combining with airborne compounds to initiate a change in cell activity. These receptors are used for the sense of smell. 39 0.0964057942354279 0 0 1 C01D.profile.u50 opioid receptor activity GO:0004985 Combining with an opioid, any narcotic derived from or resembling opium, to initiate a change in cell activity. 14 0.0346072081870767 0 0 1 C01D.profile.u50 serotonin receptor activity GO:0004993 Combining with the biogenic amine serotonin, a neurotransmitter and hormone found in vertebrates, invertebrates and plants, to initiate a change in cell activity. 19 0.0469669253967469 0 0 1 C01D.profile.u50 vasoactive intestinal polypeptide receptor activity GO:0004999 9 0.0222474909774064 0 0 1 C01D.profile.u50 transmembrane receptor protein tyrosine phosphatase activity GO:0005001 32 0.0791021901418896 0 0 1 C01D.profile.u50 ephrin receptor activity GO:0005003 Combining with an ephrin to initiate a change in cell activity. 25 0.0617985860483512 1 16.1816 0.0599997083577651 C01D.profile.u50 vascular endothelial growth factor receptor activity GO:0005021 Combining with vascular endothelial growth factor to initiate a change in cell activity. 22 0.0543827557225491 0 0 1 C01D.profile.u50 transforming growth factor beta receptor activity GO:0005024 Combining with transforming growth factor beta to initiate a change in cell activity. 24 0.0593266426064172 0 0 1 C01D.profile.u50 transforming growth factor beta receptor activity, type I GO:0005025 Combining with transforming growth factor beta to initiate a change in cell activity; upon ligand binding, catalyzes the phosphorylation of a type I TGF-beta receptor. 10 0.0247194344193405 0 0 1 C01D.profile.u50 tumor necrosis factor receptor activity GO:0005031 Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function. 11 0.0271913778612745 0 0 1 C01D.profile.u50 death receptor activity GO:0005035 12 0.0296633213032086 0 0 1 C01D.profile.u50 low-density lipoprotein receptor activity GO:0005041 Combining with a low-density lipoprotein to initiate a change in cell activity. 16 0.0395510950709448 1 25.28375 0.0388262256909156 C01D.profile.u50 scavenger receptor activity GO:0005044 Combining with acetylated low-density lipoproteins, advanced glycation end products, or other polyanionic ligands to initiate a change in cell activity. 34 0.0840460770257577 0 0 1 C01D.profile.u50 signal sequence binding GO:0005048 Interacting selectively with a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized. 51 0.126069115538636 0 0 1 C01D.profile.u50 receptor signaling protein activity GO:0005057 246 0.608098086715776 0 0 1 C01D.profile.u50 transmembrane receptor protein tyrosine kinase signaling protein activity GO:0005066 15 0.0370791516290107 0 0 1 C01D.profile.u50 SH3/SH2 adaptor activity GO:0005070 Interacting selectively and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68). 77 0.190339645028922 0 0 1 C01D.profile.u50 transmembrane receptor protein serine/threonine kinase signaling protein activity GO:0005071 10 0.0247194344193405 0 0 1 C01D.profile.u50 protein kinase C binding GO:0005080 Interacting selectively with protein kinase C. 28 0.0692144163741534 0 0 1 C01D.profile.u50 small GTPase regulator activity GO:0005083 Modulates the rate of GTP hydrolysis by a small monomeric GTPase. 311 0.768774410441489 2 2.60154340836013 0.179927722262909 C01D.profile.u50 guanyl-nucleotide exchange factor activity GO:0005085 Stimulates the exchange of guanyl nucleotides by a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 198 0.489444801502942 2 4.08626262626263 0.0868300964276567 C01D.profile.u50 ARF guanyl-nucleotide exchange factor activity GO:0005086 Stimulates the exchange of guanyl nucleotides by the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 24 0.0593266426064172 0 0 1 C01D.profile.u50 Ras guanyl-nucleotide exchange factor activity GO:0005088 Stimulates the exchange of guanyl nucleotides by a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 124 0.306520986799822 2 6.52483870967742 0.0382025362176005 C01D.profile.u50 Rho guanyl-nucleotide exchange factor activity GO:0005089 Stimulates the exchange of guanyl nucleotides by a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. 104 0.257082117961141 0 0 1 C01D.profile.u50 GDP-dissociation inhibitor activity GO:0005092 Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding. 11 0.0271913778612745 0 0 1 C01D.profile.u50 GTPase inhibitor activity GO:0005095 Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate. 16 0.0395510950709448 0 0 1 C01D.profile.u50 GTPase activator activity GO:0005096 Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. 259 0.640233351460919 1 1.5619305019305 0.473248283820582 C01D.profile.u50 Rab GTPase activator activity GO:0005097 Increases the rate of GTP hydrolysis by a GTPase of the Rab family. 48 0.118653285212834 0 0 1 C01D.profile.u50 Ras GTPase activator activity GO:0005099 Increases the rate of GTP hydrolysis by a GTPase of the Ras superfamily. 111 0.274385722054679 1 3.6445045045045 0.240219280999167 C01D.profile.u50 Rho GTPase activator activity GO:0005100 Increases the rate of GTP hydrolysis by a GTPase of the Rho family. 34 0.0840460770257577 0 0 1 C01D.profile.u50 receptor binding GO:0005102 Interacting selectively with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. 989 2.44475206407277 3 1.22711830131446 0.442081338137346 C01D.profile.u50 fibroblast growth factor receptor binding GO:0005104 Interacting selectively with the fibroblast growth factor receptor (FGFR). 11 0.0271913778612745 0 0 1 C01D.profile.u50 Notch binding GO:0005112 Interacting selectively with the Notch (N) protein, a surface receptor. 14 0.0346072081870767 0 0 1 C01D.profile.u50 death receptor binding GO:0005123 Interacting selectively with a death receptor. 10 0.0247194344193405 0 0 1 C01D.profile.u50 cytokine activity GO:0005125 Functions to control the survival, growth, differentiation and effector function of tissues and cells. 287 0.709447767835072 0 0 1 C01D.profile.u50 hematopoietin/interferon-class (D200-domain) cytokine receptor binding GO:0005126 52 0.128541058980571 0 0 1 C01D.profile.u50 interferon-alpha/beta receptor binding GO:0005132 Interacting selectively with the interferon-alpha/beta receptor. 9 0.0222474909774064 0 0 1 C01D.profile.u50 interleukin-1 receptor binding GO:0005149 Interacting selectively with the interleukin-1 receptor. 18 0.0444949819548129 0 0 1 C01D.profile.u50 interleukin-1 receptor antagonist activity GO:0005152 Blocks the binding of interleukin-1 to the interleukin-1 receptor complex. 10 0.0247194344193405 0 0 1 C01D.profile.u50 epidermal growth factor receptor binding GO:0005154 Interacting selectively with the epidermal growth factor receptor. 15 0.0370791516290107 0 0 1 C01D.profile.u50 insulin receptor binding GO:0005158 Interacting selectively with the insulin receptor. 26 0.0642705294902853 0 0 1 C01D.profile.u50 insulin-like growth factor receptor binding GO:0005159 Interacting selectively with the insulin-like growth factor receptor. 18 0.0444949819548129 0 0 1 C01D.profile.u50 transforming growth factor beta receptor binding GO:0005160 Interacting selectively with the transforming growth factor beta receptor. 14 0.0346072081870767 0 0 1 C01D.profile.u50 tumor necrosis factor receptor binding GO:0005164 Interacting selectively with the tumor necrosis factor receptor. 29 0.0716863598160874 0 0 1 C01D.profile.u50 integrin binding GO:0005178 Interacting selectively with an integrin. 84 0.20764324912246 0 0 1 C01D.profile.u50 hormone activity GO:0005179 The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects. 131 0.32382459089336 0 0 1 C01D.profile.u50 neuropeptide hormone activity GO:0005184 The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones. 28 0.0692144163741534 0 0 1 C01D.profile.u50 structural molecule activity GO:0005198 The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell. 937 2.3162110050922 1 0.431739594450374 0.901635813833561 C01D.profile.u50 structural constituent of cytoskeleton GO:0005200 The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. 156 0.385623176941712 1 2.59320512820513 0.320297844371257 C01D.profile.u50 extracellular matrix structural constituent GO:0005201 The action of a molecule that contributes to the structural integrity of the extracellular matrix. 163 0.40292678103525 0 0 1 C01D.profile.u50 structural constituent of eye lens GO:0005212 The action of a molecule that contributes to the structural integrity of the lens of an eye. 17 0.0420230385128788 0 0 1 C01D.profile.u50 transporter activity GO:0005215 Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells. 1472 3.63870074652692 4 1.09929347826087 0.493146499275225 C01D.profile.u50 ion channel activity GO:0005216 Allows the regulatable energy-independent passage of ions across a lipid bilayer down a concentration gradient. 403 0.996193207099422 2 2.00764267990074 0.262838757582826 C01D.profile.u50 intracellular ligand-gated ion channel activity GO:0005217 23 0.0568546991644831 0 0 1 C01D.profile.u50 calcium activated cation channel activity GO:0005227 The transporter activity that allows the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient. 14 0.0346072081870767 0 0 1 C01D.profile.u50 extracellular ligand-gated ion channel activity GO:0005230 80 0.197755475354724 1 5.05675 0.179630392212937 C01D.profile.u50 excitatory extracellular ligand-gated ion channel activity GO:0005231 63 0.155732436841845 0 0 1 C01D.profile.u50 glutamate-gated ion channel activity GO:0005234 26 0.0642705294902853 0 0 1 C01D.profile.u50 inward rectifier potassium channel activity GO:0005242 27 0.0667424729322193 0 0 1 C01D.profile.u50 gap-junction forming channel activity GO:0005243 15 0.0370791516290107 0 0 1 C01D.profile.u50 voltage-gated ion channel activity GO:0005244 A channel in a cell membrane whose opening is governed by the membrane potential. 201 0.496860631828744 1 2.0126368159204 0.391936372149694 C01D.profile.u50 voltage-gated calcium channel activity GO:0005245 Allows movement of calcium across a cell membrane through a transmembrane channel whose opening and closing is responsive to changes in membrane potential. 39 0.0964057942354279 0 0 1 C01D.profile.u50 calcium channel regulator activity GO:0005246 16 0.0395510950709448 0 0 1 C01D.profile.u50 voltage-gated chloride channel activity GO:0005247 26 0.0642705294902853 1 15.5592307692308 0.0623233359141062 C01D.profile.u50 voltage-gated sodium channel activity GO:0005248 18 0.0444949819548129 0 0 1 C01D.profile.u50 voltage-gated potassium channel activity GO:0005249 105 0.259554061403075 0 0 1 C01D.profile.u50 delayed rectifier potassium channel activity GO:0005251 17 0.0420230385128788 0 0 1 C01D.profile.u50 anion channel activity GO:0005253 The transporter activity that allows the energy-independent passage of anions across a lipid bilayer down a concentration gradient. 76 0.187867701586988 2 10.6457894736842 0.0154283332046063 C01D.profile.u50 chloride channel activity GO:0005254 68 0.168092154051515 2 11.8982352941176 0.0124932388467086 C01D.profile.u50 cation channel activity GO:0005261 The transporter activity that allows the energy-independent passage of cations across a lipid bilayer down a concentration gradient. 277 0.684728333415731 0 0 1 C01D.profile.u50 calcium channel activity GO:0005262 89 0.22000296633213 0 0 1 C01D.profile.u50 potassium channel activity GO:0005267 121 0.29910515647402 0 0 1 C01D.profile.u50 sodium channel activity GO:0005272 34 0.0840460770257577 0 0 1 C01D.profile.u50 amine transporter activity GO:0005275 Enables the directed movement of amines, including polyamines, into, out of, within or between cells. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group. 83 0.205171305680526 0 0 1 C01D.profile.u50 amino acid-polyamine transporter activity GO:0005279 26 0.0642705294902853 0 0 1 C01D.profile.u50 sodium:amino acid symporter activity GO:0005283 Catalysis of the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in). 9 0.0222474909774064 0 0 1 C01D.profile.u50 dicarboxylic acid transporter activity GO:0005310 Enables the directed movement of dicarboxylic acids into, out of, within or between cells. A dicarboxylic acid is an organic acid with two COOH groups. 18 0.0444949819548129 0 0 1 C01D.profile.u50 L-glutamate transporter activity GO:0005313 Enables the directed movement of L-glutamate, the anion of 2-aminopentanedioic acid, into, out of, within or between cells. 13 0.0321352647451426 0 0 1 C01D.profile.u50 lipid transporter activity GO:0005319 Enables the directed movement of lipids into, out of, within or between cells. 105 0.259554061403075 1 3.8527619047619 0.228852329425735 C01D.profile.u50 neurotransmitter transporter activity GO:0005326 Enables the directed movement of a neurotransmitter into, out of, within or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. 27 0.0667424729322193 0 0 1 C01D.profile.u50 neurotransmitter:sodium symporter activity GO:0005328 Catalysis of the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in). 25 0.0617985860483512 0 0 1 C01D.profile.u50 nucleoside transporter activity GO:0005337 Enables the directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), into, out of, within or between cells. 8 0.0197755475354724 0 0 1 C01D.profile.u50 nucleotide-sugar transporter activity GO:0005338 Enables the directed movement of nucleotide-sugars into, out of, within or between cells. A nucleotide-sugars is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. 13 0.0321352647451426 0 0 1 C01D.profile.u50 organic acid transporter activity GO:0005342 Enables the directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of, within or between cells. 103 0.254610174519207 0 0 1 C01D.profile.u50 organic acid:sodium symporter activity GO:0005343 Catalysis of the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in). 28 0.0692144163741534 0 0 1 C01D.profile.u50 oxygen transporter activity GO:0005344 Enables the directed movement of oxygen into, out of, within or between cells. 14 0.0346072081870767 0 0 1 C01D.profile.u50 sugar porter activity GO:0005351 Catalysis of the reaction: sugar(out) + H+(out) = sugar(in) + H+(in). 43 0.106293568003164 0 0 1 C01D.profile.u50 glucose transporter activity GO:0005355 Enables the directed movement of the hexose monosaccharide glucose into, out of, within or between cells. 18 0.0444949819548129 0 0 1 C01D.profile.u50 water transporter activity GO:0005372 Enables the directed movement of water (H2O) into, out of, within or between cells. 18 0.0444949819548129 0 0 1 C01D.profile.u50 copper ion transporter activity GO:0005375 Enables the directed movement of copper (Cu) ions into, out of, within or between cells. 10 0.0247194344193405 0 0 1 C01D.profile.u50 carrier activity GO:0005386 Catalysis of the transfer of a specific substance or related group of substances from one side of the membrane to the other. 397 0.981361546447817 0 0 1 C01D.profile.u50 calcium-transporting ATPase activity GO:0005388 Catalysis of the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). 26 0.0642705294902853 0 0 1 C01D.profile.u50 sodium:potassium-exchanging ATPase activity GO:0005391 Catalysis of the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in). 12 0.0296633213032086 0 0 1 C01D.profile.u50 cation:amino acid symporter activity GO:0005416 Catalysis of the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in). 10 0.0247194344193405 0 0 1 C01D.profile.u50 sodium:phosphate symporter activity GO:0005436 Catalysis of the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in). 7 0.0173036040935383 0 0 1 C01D.profile.u50 monovalent cation:proton antiporter activity GO:0005451 Catalysis of the reaction: monovalent cation(out) + H+(in) = monovalent cation(in) + H+(out). 8 0.0197755475354724 0 0 1 C01D.profile.u50 inorganic anion exchanger activity GO:0005452 13 0.0321352647451426 0 0 1 C01D.profile.u50 intracellular transporter activity GO:0005478 Enables the directed movement of substances within a cell. 54 0.133484945864439 1 7.49148148148148 0.125103951918425 C01D.profile.u50 SNAP receptor activity GO:0005484 Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. 19 0.0469669253967469 0 0 1 C01D.profile.u50 nucleocytoplasmic transporter activity GO:0005487 Enables the directed movement of substances between the nucleus and the cytoplasm of a cell. 14 0.0346072081870767 1 28.8957142857143 0.0340566132519083 C01D.profile.u50 binding GO:0005488 The selective, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. 13359 33.022692440797 32 0.969030616064076 0.594115627163672 C01D.profile.u50 steroid binding GO:0005496 Interacting selectively with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. 79 0.19528353191279 1 5.12075949367089 0.177597459646681 C01D.profile.u50 retinoid binding GO:0005501 Interacting selectively with retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity. 13 0.0321352647451426 0 0 1 C01D.profile.u50 fatty acid binding GO:0005504 Interacting selectively with fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. 28 0.0692144163741534 0 0 1 C01D.profile.u50 iron ion binding GO:0005506 Interacting selectively with iron (Fe) ions. 372 0.919562960399466 0 0 1 C01D.profile.u50 copper ion binding GO:0005507 Interacting selectively with copper (Cu) ions. 74 0.18292381470312 2 10.9335135135135 0.0146693077520376 C01D.profile.u50 calcium ion binding GO:0005509 Interacting selectively with calcium ions (Ca2+). 1112 2.74880110743066 2 0.727589928057554 0.760440314025114 C01D.profile.u50 protein binding GO:0005515 Interacting selectively with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). 8108 20.0425174272013 24 1.19745436605821 0.21511338409334 C01D.profile.u50 calmodulin binding GO:0005516 Interacting selectively with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. 227 0.561131161319029 0 0 1 C01D.profile.u50 collagen binding GO:0005518 Interacting selectively with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). 34 0.0840460770257577 0 0 1 C01D.profile.u50 insulin-like growth factor binding GO:0005520 Interacting selectively with an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it. 36 0.0889899639096258 0 0 1 C01D.profile.u50 tropomyosin binding GO:0005523 Interacting selectively with tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle. 19 0.0469669253967469 0 0 1 C01D.profile.u50 ATP binding GO:0005524 Interacting selectively with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. 1792 4.42972264794582 5 1.12873883928571 0.454608876923268 C01D.profile.u50 GTP binding GO:0005525 Interacting selectively with GTP, guanosine triphosphate. 449 1.10990260542839 0 0 1 C01D.profile.u50 macrolide binding GO:0005527 Interacting selectively with a macrolide, any of a large group of structurally related antibiotics produced by Streptomyces species. 12 0.0296633213032086 0 0 1 C01D.profile.u50 FK506 binding GO:0005528 Interacting selectively with the immunosuppressant FK506. 12 0.0296633213032086 0 0 1 C01D.profile.u50 sugar binding GO:0005529 Interacting selectively with any mono-, di- or trisaccharide carbohydrate. 190 0.469669253967469 0 0 1 C01D.profile.u50 mannose binding GO:0005537 Interacting selectively with mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans. 14 0.0346072081870767 0 0 1 C01D.profile.u50 glycosaminoglycan binding GO:0005539 Interacting selectively with any glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues. 171 0.422702328570722 0 0 1 C01D.profile.u50 hyaluronic acid binding GO:0005540 Interacting selectively with hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine. 33 0.0815741335838236 0 0 1 C01D.profile.u50 folic acid binding GO:0005542 Interacting selectively with folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. 14 0.0346072081870767 0 0 1 C01D.profile.u50 phospholipid binding GO:0005543 Interacting selectively with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester. 296 0.731695258812478 1 1.36668918918919 0.519342877724214 C01D.profile.u50 calcium-dependent phospholipid binding GO:0005544 Interacting selectively with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. 30 0.0741583032580215 0 0 1 C01D.profile.u50 phosphatidylinositol binding GO:0005545 Interacting selectively with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. 18 0.0444949819548129 0 0 1 C01D.profile.u50 phosphatidylinositol-3,4,5-triphosphate binding GO:0005547 Interacting selectively with phosphatidylinositol-3,4,5-triphosphate, the triphosphorylated derivative of phosphatidylinositol. 7 0.0173036040935383 0 0 1 C01D.profile.u50 phospholipid transporter activity GO:0005548 Enables the directed movement of phospholipids into, out of, within or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester. 36 0.0889899639096258 0 0 1 C01D.profile.u50 chemokine activity GO:0008009 The function of a family of chemotactic pro-inflammatory activation-inducible cytokines acting primarily upon hemopoietic cells in immunoregulatory processes; all chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. 56 0.138428832748307 0 0 1 C01D.profile.u50 beta-catenin binding GO:0008013 Interacting selectively with the beta subunit of the catenin complex. 10 0.0247194344193405 0 0 1 C01D.profile.u50 microtubule binding GO:0008017 Interacting selectively with microtubules, filaments composed of tubulin monomers. 73 0.180451871261186 1 5.54164383561644 0.165293633534382 C01D.profile.u50 G-protein coupled photoreceptor activity GO:0008020 A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light. 6 0.0148316606516043 0 0 1 C01D.profile.u50 protein C-terminus binding GO:0008022 Interacting selectively with a protein C-terminus, the end of any peptide chain at which the 1-carboxy function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. 88 0.217531022890196 0 0 1 C01D.profile.u50 ATP-dependent helicase activity GO:0008026 Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix. 137 0.338656251544965 1 2.95284671532847 0.287571349970517 C01D.profile.u50 monocarboxylic acid transporter activity GO:0008028 Enables the directed movement of monocarboxylic acids into, out of, within or between cells. A monocarboxylic acid is an organic acid with one COOH group. 28 0.0692144163741534 0 0 1 C01D.profile.u50 lipoprotein binding GO:0008034 Interacting selectively with any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids. 39 0.0964057942354279 1 10.3728205128205 0.0920129347469056 C01D.profile.u50 enzyme activator activity GO:0008047 Increases the activity of an enzyme. 397 0.981361546447817 1 1.01899244332494 0.625654639607621 C01D.profile.u50 glutamate receptor activity GO:0008066 Combining with glutamate to initiate a change in cell activity. 52 0.128541058980571 0 0 1 C01D.profile.u50 metabotropic glutamate, GABA-B-like receptor activity GO:0008067 A G-protein coupled receptor that is structurally/functionally related to the metabotropic glutamate receptor. 26 0.0642705294902853 0 0 1 C01D.profile.u50 translation termination factor activity GO:0008079 Functions in the termination of translation. 9 0.0222474909774064 0 0 1 C01D.profile.u50 N-acetyltransferase activity GO:0008080 Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. 64 0.158204380283779 1 6.3209375 0.146491893854714 C01D.profile.u50 phosphoric diester hydrolase activity GO:0008081 Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. 108 0.266969891728877 0 0 1 C01D.profile.u50 growth factor activity GO:0008083 The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. 247 0.61057003015771 0 0 1 C01D.profile.u50 cytoskeletal protein binding GO:0008092 Interacting selectively with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton). 618 1.52766104711524 2 1.30919093851133 0.451606044893653 C01D.profile.u50 cytoskeletal adaptor activity GO:0008093 The binding activity of a molecule that brings together a cytoskeletal molecule and one or more other molecules, permitting them to function in a coordinated way. 20 0.049438868838681 0 0 1 C01D.profile.u50 DNA-dependent ATPase activity GO:0008094 Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of double-stranded DNA; drives another reaction. 71 0.175507984377317 1 5.69774647887324 0.161151587657948 C01D.profile.u50 ubiquinol-cytochrome-c reductase activity GO:0008121 Catalysis of the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c. 10 0.0247194344193405 0 0 1 C01D.profile.u50 transcription factor binding GO:0008134 Interacting selectively with a transcription factor, any protein required to initiate or regulate transcription. 612 1.51282938646364 2 1.32202614379085 0.44667078748535 C01D.profile.u50 translation factor activity, nucleic acid binding GO:0008135 Functions during translation by binding nucleic acids during polypeptide synthesis at the ribosome. 118 0.291689326148218 0 0 1 C01D.profile.u50 NADH dehydrogenase (ubiquinone) activity GO:0008137 Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol. 39 0.0964057942354279 0 0 1 C01D.profile.u50 protein tyrosine/serine/threonine phosphatase activity GO:0008138 61 0.150788549957977 0 0 1 C01D.profile.u50 nuclear localization sequence binding GO:0008139 Interacting selectively with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus. 29 0.0716863598160874 0 0 1 C01D.profile.u50 drug binding GO:0008144 Interacting selectively with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. 35 0.0865180204676917 0 0 1 C01D.profile.u50 sulfotransferase activity GO:0008146 Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. 47 0.1161813417709 0 0 1 C01D.profile.u50 hedgehog receptor activity GO:0008158 Combining with the hedgehog protein to initiate a change in cell activity. 7 0.0173036040935383 0 0 1 C01D.profile.u50 positive transcription elongation factor activity GO:0008159 Any activity that increases the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation. 10 0.0247194344193405 0 0 1 C01D.profile.u50 methyltransferase activity GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule. 157 0.388095120383646 0 0 1 C01D.profile.u50 N-methyltransferase activity GO:0008170 Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule. 45 0.111237454887032 0 0 1 C01D.profile.u50 O-methyltransferase activity GO:0008171 Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule. 16 0.0395510950709448 0 0 1 C01D.profile.u50 S-methyltransferase activity GO:0008172 Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule. 6 0.0148316606516043 0 0 1 C01D.profile.u50 RNA methyltransferase activity GO:0008173 Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. 23 0.0568546991644831 0 0 1 C01D.profile.u50 tRNA methyltransferase activity GO:0008175 Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule. 10 0.0247194344193405 0 0 1 C01D.profile.u50 RNA-dependent ATPase activity GO:0008186 Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of RNA; drives another reaction. 39 0.0964057942354279 0 0 1 C01D.profile.u50 neuropeptide receptor activity GO:0008188 Combining with a neuropeptide to initiate a change in cell activity. 39 0.0964057942354279 0 0 1 C01D.profile.u50 metalloendopeptidase inhibitor activity GO:0008191 Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides and contain a chelated metal ion at their active sites which is essential to their catalytic activity. 20 0.049438868838681 0 0 1 C01D.profile.u50 UDP-glycosyltransferase activity GO:0008194 Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule. 119 0.294161269590152 0 0 1 C01D.profile.u50 ferric iron binding GO:0008199 Interacting selectively with ferric iron, Fe(III). 9 0.0222474909774064 0 0 1 C01D.profile.u50 ion channel inhibitor activity GO:0008200 13 0.0321352647451426 0 0 1 C01D.profile.u50 heparin binding GO:0008201 Interacting selectively with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha1-4-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. 131 0.32382459089336 0 0 1 C01D.profile.u50 amine receptor activity GO:0008227 Combining with a biogenic amine to initiate a change in cell activity. 56 0.138428832748307 0 0 1 C01D.profile.u50 peptidase activity GO:0008233 Catalysis of the hydrolysis of peptide bonds. 636 1.57215602907005 0 0 1 C01D.profile.u50 cysteine-type peptidase activity GO:0008234 Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides; a cysteine residue is at the active center. 180 0.444949819548129 0 0 1 C01D.profile.u50 metalloexopeptidase activity GO:0008235 Catalysis of the hydrolysis of terminal peptide linkages in oligopeptides or polypeptides. Enzymes of this class contain a chelated metal ion essential to their catalytic activity at their active sites. 63 0.155732436841845 0 0 1 C01D.profile.u50 serine-type peptidase activity GO:0008236 Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). 180 0.444949819548129 0 0 1 C01D.profile.u50 metallopeptidase activity GO:0008237 209 0.516636179364216 0 0 1 C01D.profile.u50 exopeptidase activity GO:0008238 Catalysis of the cleavage of the terminal or penultimate peptide bond of a peptide chain, releasing a single amino acid or dipeptide. Exopeptidases are classified as aminopeptidases, carboxypeptidases, dipeptidases, and omega peptidases. 104 0.257082117961141 0 0 1 C01D.profile.u50 dipeptidyl-peptidase activity GO:0008239 Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain. 12 0.0296633213032086 0 0 1 C01D.profile.u50 omega peptidase activity GO:0008242 Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of a-carboxyl to a-amino groups). 5 0.0123597172096702 0 0 1 C01D.profile.u50 nucleotidase activity GO:0008252 Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate. 5 0.0123597172096702 0 0 1 C01D.profile.u50 5'-nucleotidase activity GO:0008253 Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. 3 0.00741583032580215 0 0 1 C01D.profile.u50 zinc ion binding GO:0008270 Interacting selectively with zinc (Zn) ions. 2200 5.43827557225491 9 1.65493636363636 0.100216825413721 C01D.profile.u50 sulfate porter activity GO:0008271 10 0.0247194344193405 0 0 1 C01D.profile.u50 protein methyltransferase activity GO:0008276 Catalysis of the transfer of a methyl group (CH3-) to a protein. 43 0.106293568003164 0 0 1 C01D.profile.u50 lipid binding GO:0008289 Interacting selectively with a lipid. 539 1.33237751520245 3 2.25161410018553 0.150213772410169 C01D.profile.u50 DNA bending activity GO:0008301 The function of causing local conformational micropolymorphism of DNA in which the original B-DNA structure is only distorted but not extensively modified. 14 0.0346072081870767 0 0 1 C01D.profile.u50 structural constituent of muscle GO:0008307 The action of a molecule that contributes to the structural integrity of a muscle fiber. 70 0.173036040935383 0 0 1 C01D.profile.u50 voltage-gated ion-selective channel activity GO:0008308 8 0.0197755475354724 0 0 1 C01D.profile.u50 protein prenyltransferase activity GO:0008318 Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein. 11 0.0271913778612745 0 0 1 C01D.profile.u50 cation transporter activity GO:0008324 Enables the directed movement of atoms or small molecules with a positive charge into, out of, within or between cells. 627 1.54990853809265 0 0 1 C01D.profile.u50 pattern recognition receptor activity GO:0008329 Combining with a molecular pattern based on a repeating or polymeric structure, such as a polysaccharide or peptidoglycan, to initiate a change in cell activity. Such molecular patterns are sometimes associated with potential pathogens. 8 0.0197755475354724 0 0 1 C01D.profile.u50 bacterial binding GO:0008367 Interacting selectively with any part of a bacterial cell. 13 0.0321352647451426 0 0 1 C01D.profile.u50 sialyltransferase activity GO:0008373 Catalysis of the formation of sialylglycoconjugates via transfer of the sialic acid group from CMP to one of several glycoconjugate acceptors. 22 0.0543827557225491 0 0 1 C01D.profile.u50 O-acyltransferase activity GO:0008374 Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule. 30 0.0741583032580215 1 13.4846666666667 0.0715605491904371 C01D.profile.u50 acetylglucosaminyltransferase activity GO:0008375 Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to an oligosaccharide. 40 0.098877737677362 0 0 1 C01D.profile.u50 acetylgalactosaminyltransferase activity GO:0008376 Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide. 29 0.0716863598160874 0 0 1 C01D.profile.u50 galactosyltransferase activity GO:0008378 Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. 35 0.0865180204676917 0 0 1 C01D.profile.u50 steroid hydroxylase activity GO:0008395 Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2. 15 0.0370791516290107 0 0 1 C01D.profile.u50 3'-5' exonuclease activity GO:0008408 Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. 35 0.0865180204676917 0 0 1 C01D.profile.u50 acyltransferase activity GO:0008415 Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier. 192 0.474613140851337 2 4.21395833333333 0.0824129041283454 C01D.profile.u50 fucosyltransferase activity GO:0008417 Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. 27 0.0667424729322193 0 0 1 C01D.profile.u50 selenium binding GO:0008430 Interacting selectively with selenium (Se). 27 0.0667424729322193 0 0 1 C01D.profile.u50 inositol trisphosphate 3-kinase activity GO:0008440 Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate. 5 0.0123597172096702 0 0 1 C01D.profile.u50 phosphofructokinase activity GO:0008443 Catalysis of the transfer of a phosphate group, usually from ATP, to a fructose substrate molecule. 9 0.0222474909774064 0 0 1 C01D.profile.u50 transaminase activity GO:0008483 Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. 36 0.0889899639096258 0 0 1 C01D.profile.u50 sulfuric ester hydrolase activity GO:0008484 Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2. 32 0.0791021901418896 0 0 1 C01D.profile.u50 tetracycline transporter activity GO:0008493 Enables the directed movement of tetracycline into, out of, within or between cells. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles). 3 0.00741583032580215 0 0 1 C01D.profile.u50 translation activator activity GO:0008494 Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide. 8 0.0197755475354724 0 0 1 C01D.profile.u50 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity GO:0008499 Catalysis of the reaction: UDP-galactose + N-acetylglucosamine = galactose-beta-1,3-N-acetylglucosamine + UDP. 8 0.0197755475354724 0 0 1 C01D.profile.u50 benzodiazepine receptor activity GO:0008503 Combining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity. 6 0.0148316606516043 0 0 1 C01D.profile.u50 bile acid:sodium symporter activity GO:0008508 Catalysis of the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in). 3 0.00741583032580215 0 0 1 C01D.profile.u50 anion transporter activity GO:0008509 Enables the directed movement of atoms or small molecules with a negative charge into, out of, within or between cells. 165 0.407870667919118 2 4.90351515151515 0.0634754669504507 C01D.profile.u50 organic anion transporter activity GO:0008514 Enables the directed movement of organic anions into, out of, within or between cells. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. 16 0.0395510950709448 0 0 1 C01D.profile.u50 phosphatidylinositol transporter activity GO:0008526 Enables the directed movement of phosphatidylinositol into, out of, within or between cells. Phosphatidylinositol refers to any glycophospholipids with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. 8 0.0197755475354724 0 0 1 C01D.profile.u50 taste receptor activity GO:0008527 Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste. 10 0.0247194344193405 0 0 1 C01D.profile.u50 peptide receptor activity, G-protein coupled GO:0008528 142 0.351015968754635 0 0 1 C01D.profile.u50 astacin activity GO:0008533 Catalysis of the hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'. 10 0.0247194344193405 0 0 1 C01D.profile.u50 Ran GTPase binding GO:0008536 Interacting selectively with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly. 25 0.0617985860483512 0 0 1 C01D.profile.u50 hydrogen-exporting ATPase activity, phosphorylative mechanism GO:0008553 Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism. 8 0.0197755475354724 0 0 1 C01D.profile.u50 protein transporter activity GO:0008565 Enables the directed movement of proteins into, out of, within or between cells. 135 0.333712364661097 0 0 1 C01D.profile.u50 protein phosphatase type 2A regulator activity GO:0008601 Modulation of the activity of the enzyme protein phosphatase type 2A. 36 0.0889899639096258 0 0 1 C01D.profile.u50 cAMP-dependent protein kinase regulator activity GO:0008603 Modulation of the activity of the enzyme cAMP-dependent protein kinase. 17 0.0420230385128788 0 0 1 C01D.profile.u50 small protein conjugating enzyme activity GO:0008639 Catalysis of the covalent attachment of small proteins, such as ubiquitin or ubiquitin-like proteins, to lysine residues on a target protein. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase. 180 0.444949819548129 0 0 1 C01D.profile.u50 small protein activating enzyme activity GO:0008641 Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond. 2 0.0049438868838681 0 0 1 C01D.profile.u50 caspase activator activity GO:0008656 Increases the rate of proteolysis catalyzed by a caspase. 23 0.0568546991644831 0 0 1 C01D.profile.u50 D-alanyl-D-alanine endopeptidase activity GO:0008717 4 0.00988777376773619 0 0 1 C01D.profile.u50 S-adenosylmethionine-dependent methyltransferase activity GO:0008757 Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate. 79 0.19528353191279 0 0 1 C01D.profile.u50 glycerophosphodiester phosphodiesterase activity GO:0008889 Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate. 5 0.0123597172096702 0 0 1 C01D.profile.u50 signal peptidase activity GO:0009003 Catalysis of the cleavage of a signal peptide from a protein precursor. 7 0.0173036040935383 0 0 1 C01D.profile.u50 electron carrier activity GO:0009055 Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system. 188 0.464725367083601 0 0 1 C01D.profile.u50 photoreceptor activity GO:0009881 The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation. 7 0.0173036040935383 0 0 1 C01D.profile.u50 cyclase activity GO:0009975 Catalysis of a ring closure reaction. 33 0.0815741335838236 0 0 1 C01D.profile.u50 pseudouridine synthase activity GO:0009982 Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. 26 0.0642705294902853 0 0 1 C01D.profile.u50 FMN binding GO:0010181 Interacting selectively with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. 13 0.0321352647451426 0 0 1 C01D.profile.u50 heme-copper terminal oxidase activity GO:0015002 Catalysis of the four-electron reduction of dioxygen (O2) to water, coupled to generation of a proton electrochemical gradient across a membrane. 36 0.0889899639096258 0 0 1 C01D.profile.u50 glucuronosyltransferase activity GO:0015020 Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. 21 0.051910812280615 0 0 1 C01D.profile.u50 coreceptor activity GO:0015026 Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity. 27 0.0667424729322193 0 0 1 C01D.profile.u50 protein disulfide oxidoreductase activity GO:0015035 15 0.0370791516290107 0 0 1 C01D.profile.u50 disulfide oxidoreductase activity GO:0015036 21 0.051910812280615 0 0 1 C01D.profile.u50 ion transporter activity GO:0015075 Enables the directed movement of charged atoms or small charged molecules into, out of, within or between cells. 812 2.00721807485045 2 0.996403940886699 0.596280500163231 C01D.profile.u50 monovalent inorganic cation transporter activity GO:0015077 Enables the directed movement of inorganic cations with a valency of one into, out of, within or between cells. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage. 144 0.355959855638503 0 0 1 C01D.profile.u50 hydrogen ion transporter activity GO:0015078 Enables the directed movement of hydrogen ions into, out of, within or between cells. 127 0.313936817125624 0 0 1 C01D.profile.u50 di-, tri-valent inorganic cation transporter activity GO:0015082 Enables the directed movement of inorganic cations with a valency of two or three into, out of, within or between cells. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage. 69 0.170564097493449 0 0 1 C01D.profile.u50 calcium ion transporter activity GO:0015085 Enables the directed movement of calcium (Ca) ions into, out of, within or between cells. 39 0.0964057942354279 0 0 1 C01D.profile.u50 organic cation transporter activity GO:0015101 Enables the directed movement of organic cations into, out of, within or between cells. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage. 12 0.0296633213032086 0 0 1 C01D.profile.u50 inorganic anion transporter activity GO:0015103 Enables the directed movement of inorganic anions into, out of, within or between cells. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage. 41 0.101349681119296 0 0 1 C01D.profile.u50 bicarbonate transporter activity GO:0015106 Enables the directed movement of bicarbonate into, out of, within or between cells. Bicarbonate is the hydrogencarbonate ion, HCO3-. 15 0.0370791516290107 0 0 1 C01D.profile.u50 chloride transporter activity GO:0015108 Enables the directed movement of chloride ions into, out of, within or between cells. 18 0.0444949819548129 0 0 1 C01D.profile.u50 phosphate transporter activity GO:0015114 Enables the directed movement of phosphate (PO4 3-) ions into, out of, within or between cells. 15 0.0370791516290107 0 0 1 C01D.profile.u50 sulfate transporter activity GO:0015116 Enables the directed movement of sulfate ions (SO4 2-) into, out of, within or between cells. 10 0.0247194344193405 0 0 1 C01D.profile.u50 bile acid transporter activity GO:0015125 Enables the directed movement of bile acid into, out of, within or between cells. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. 6 0.0148316606516043 0 0 1 C01D.profile.u50 carbohydrate transporter activity GO:0015144 Enables the directed movement of carbohydrate into, out of, within or between cells. 48 0.118653285212834 0 0 1 C01D.profile.u50 monosaccharide transporter activity GO:0015145 Enables the directed movement of monosaccharide into, out of, within or between cells. 20 0.049438868838681 0 0 1 C01D.profile.u50 hexose transporter activity GO:0015149 Enables the directed movement of a hexose sugar, a monosaccharide with 6 carbon atoms, into, out of, within or between cells. 20 0.049438868838681 0 0 1 C01D.profile.u50 pyrimidine nucleotide sugar transporter activity GO:0015165 Enables the directed movement of pyrimidine nucleotide-sugars into, out of, within or between cells. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative. 10 0.0247194344193405 0 0 1 C01D.profile.u50 amino acid transporter activity GO:0015171 Enables the directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells. 67 0.165620210609581 0 0 1 C01D.profile.u50 acidic amino acid transporter activity GO:0015172 Enables the directed movement of acidic amino acids, amino acids with a pH below 7, into, out of, within or between cells. 14 0.0346072081870767 0 0 1 C01D.profile.u50 basic amino acid transporter activity GO:0015174 Enables the directed movement of basic amino acids, amino acids with a pH above 7, into, out of, within or between cells. 12 0.0296633213032086 0 0 1 C01D.profile.u50 neutral amino acid transporter activity GO:0015175 Enables the directed movement of neutral amino acids, amino acids with no net charge, into, out of, within or between cells. 23 0.0568546991644831 0 0 1 C01D.profile.u50 L-amino acid transporter activity GO:0015179 Enables the directed movement of L-amino acids into, out of, within or between cells. 40 0.098877737677362 0 0 1 C01D.profile.u50 peptide transporter activity GO:0015197 Enables the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of, within or between cells. 13 0.0321352647451426 0 0 1 C01D.profile.u50 oligopeptide transporter activity GO:0015198 Enables the directed movement of oligopeptides into, out of, within or between cells. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. 10 0.0247194344193405 0 0 1 C01D.profile.u50 polyamine transporter activity GO:0015203 Enables the directed movement of polyamines, organic compounds containing two or more amino groups, into, out of, within or between cells. 26 0.0642705294902853 0 0 1 C01D.profile.u50 drug transporter activity GO:0015238 Enables the directed movement of a drug into, out of, within or between cells. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. 16 0.0395510950709448 0 0 1 C01D.profile.u50 aminophospholipid transporter activity GO:0015247 Enables the directed movement of aminophospholipids into, out of, within or between cells. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group. 21 0.051910812280615 0 0 1 C01D.profile.u50 sterol transporter activity GO:0015248 Enables the directed movement of sterols into, out of, within or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. 9 0.0222474909774064 0 0 1 C01D.profile.u50 water channel activity GO:0015250 15 0.0370791516290107 0 0 1 C01D.profile.u50 channel or pore class transporter activity GO:0015267 Allows facilitated diffusion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without a carrier-mediated mechanism. They do not exhibit stereospecificity but may be specific for a particular molecular species or class of molecules. 458 1.13215009640579 2 1.76655021834061 0.312783461463921 C01D.profile.u50 alpha-type channel activity GO:0015268 Allows the movement of solutes by energy-independent process by passage through a transmembrane aqueous pore. Usually consist of alpha-helical membrane spanners, although beta-strands may be present and contribute to channel. 440 1.08765511445098 2 1.83881818181818 0.296487713647001 C01D.profile.u50 calcium-activated potassium channel activity GO:0015269 The transporter activity that allows the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient. 12 0.0296633213032086 0 0 1 C01D.profile.u50 dihydropyridine-sensitive calcium channel activity GO:0015270 13 0.0321352647451426 0 0 1 C01D.profile.u50 ligand-gated ion channel activity GO:0015276 143 0.353487912196569 1 2.82895104895105 0.298072765293967 C01D.profile.u50 kainate selective glutamate receptor activity GO:0015277 14 0.0346072081870767 0 0 1 C01D.profile.u50 calcium-release channel activity GO:0015278 14 0.0346072081870767 0 0 1 C01D.profile.u50 store-operated calcium channel activity GO:0015279 10 0.0247194344193405 0 0 1 C01D.profile.u50 amiloride-sensitive sodium channel activity GO:0015280 11 0.0271913778612745 0 0 1 C01D.profile.u50 connexon channel activity GO:0015285 15 0.0370791516290107 0 0 1 C01D.profile.u50 porin activity GO:0015288 Allows the energy independent passage of small (less than 1000 Da) solutes across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. 29 0.0716863598160874 0 0 1 C01D.profile.u50 electrochemical potential-driven transporter activity GO:0015290 Catalysis of the carrier-mediated transfer of one or more substances across a membrane. Transport occurs in three ways: uniport, a single species is transported by facilitated diffusion in a process not coupled to the utilization of a primary source of energy; antiport, two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy; and symport, two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. 240 0.593266426064172 0 0 1 C01D.profile.u50 porter activity GO:0015291 A transporter of solutes that utilizes a carrier-mediated process to catalyze uniport, symport or antiport between aqueous phases on either side of a lipid membrane. 238 0.588322539180304 0 0 1 C01D.profile.u50 symporter activity GO:0015293 Catalyze the transport of two or more molecular species across a membrane, transport being in the same direction. 133 0.328768477777228 0 0 1 C01D.profile.u50 solute:cation symporter activity GO:0015294 Catalysis of the reaction: solute(out) + cation(out) = solute(in) + cation(in). 64 0.158204380283779 0 0 1 C01D.profile.u50 anion:cation symporter activity GO:0015296 Catalysis of the reaction: anion(out) + cation(out) = anion(in) + cation(in). 45 0.111237454887032 0 0 1 C01D.profile.u50 antiporter activity GO:0015297 Catalysis of the exchange of one or more molecular species for another across a membrane. 52 0.128541058980571 0 0 1 C01D.profile.u50 solute:cation antiporter activity GO:0015298 Catalysis of the reaction: solute(out) + cation(in) = solute(in) + cation(out). 11 0.0271913778612745 0 0 1 C01D.profile.u50 solute:hydrogen antiporter activity GO:0015299 Catalysis of the reaction: solute(out) + H+(in) = solute(in) + H+(out). 11 0.0271913778612745 0 0 1 C01D.profile.u50 solute:solute antiporter activity GO:0015300 Catalysis of the reaction: solute A(out) + solute B(in) = solute A(in) + solute B(out). 21 0.051910812280615 0 0 1 C01D.profile.u50 anion:anion antiporter activity GO:0015301 Catalysis of the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out). 17 0.0420230385128788 0 0 1 C01D.profile.u50 drug:hydrogen antiporter activity GO:0015307 Catalysis of the reaction: H+(out) + drug(in) = H+(in) + drug(out). 2 0.0049438868838681 0 0 1 C01D.profile.u50 amino acid permease activity GO:0015359 Catalysis of the stereospecific transfer of amino acids, organic acids containing one or more amino substituents, across a biological membrane. 16 0.0395510950709448 0 0 1 C01D.profile.u50 calcium:cation antiporter activity GO:0015368 Catalysis of the reaction: Ca2+(in) + cation(out) = Ca2+(out) + cation(in). 11 0.0271913778612745 0 0 1 C01D.profile.u50 solute:sodium symporter activity GO:0015370 Catalysis of the reaction: solute(out) + Na+(out) = solute(in) + Na+(in). 59 0.145844663074109 0 0 1 C01D.profile.u50 cation:chloride symporter activity GO:0015377 Catalysis of the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in). 12 0.0296633213032086 0 0 1 C01D.profile.u50 anion exchanger activity GO:0015380 15 0.0370791516290107 0 0 1 C01D.profile.u50 sodium:hydrogen antiporter activity GO:0015385 Catalysis of the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). 8 0.0197755475354724 0 0 1 C01D.profile.u50 primary active transporter activity GO:0015399 Catalysis of transport of a solute against a concentration gradient using a primary energy source. Primary energy sources known to be coupled to transport are chemical, electrical and solar sources. 139 0.343600138428833 0 0 1 C01D.profile.u50 P-P-bond-hydrolysis-driven transporter activity GO:0015405 Catalysis of the transport of a solute, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. 139 0.343600138428833 0 0 1 C01D.profile.u50 protein translocase activity GO:0015450 14 0.0346072081870767 0 0 1 C01D.profile.u50 auxiliary transport protein activity GO:0015457 Facilitates transport across one or more biological membranes but do not themselves participate directly in transport. These proteins always function in conjunction with one or more established transport systems. They may provide a function connected with energy coupling to transport, play a structural role in complex formation, serve a biogenic or stability function or function in regulation. 57 0.140900776190241 0 0 1 C01D.profile.u50 potassium channel regulator activity GO:0015459 29 0.0716863598160874 0 0 1 C01D.profile.u50 acetylcholine receptor activity GO:0015464 Combining with acetylcholine to initiate a change in cell activity. 25 0.0617985860483512 0 0 1 C01D.profile.u50 cholesterol binding GO:0015485 Interacting selectively with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. 8 0.0197755475354724 0 0 1 C01D.profile.u50 cation:cation antiporter activity GO:0015491 Catalysis of the reaction: cation A(out) + cation B(in) = cation A(in) + cation B(out). 19 0.0469669253967469 0 0 1 C01D.profile.u50 tetracycline:hydrogen antiporter activity GO:0015520 Catalysis of the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out). 2 0.0049438868838681 0 0 1 C01D.profile.u50 tubulin binding GO:0015631 Interacting selectively with monomeric or multimeric forms of tubulin, including microtubules. 99 0.244722400751471 2 8.17252525252525 0.0253001940585488 C01D.profile.u50 fatty-acid ligase activity GO:0015645 Catalysis of the ligation of a long-chain carboxylic acid to an acceptor, coupled to the hydrolysis of ATP. 16 0.0395510950709448 0 0 1 C01D.profile.u50 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism GO:0015662 Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. 77 0.190339645028922 0 0 1 C01D.profile.u50 mannosidase activity GO:0015923 Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative. 22 0.0543827557225491 0 0 1 C01D.profile.u50 mannosyl-oligosaccharide mannosidase activity GO:0015924 Catalysis of the hydrolysis of the terminal alpha-D-mannose residues in oligo-mannose oligosaccharides. 17 0.0420230385128788 0 0 1 C01D.profile.u50 galactosidase activity GO:0015925 Catalysis of the hydrolysis of galactosyl compounds, substances containing a group derived from a cyclic form of galactose or a galactose derivative. 7 0.0173036040935383 0 0 1 C01D.profile.u50 glucosidase activity GO:0015926 Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative. 12 0.0296633213032086 0 0 1 C01D.profile.u50 hexosaminidase activity GO:0015929 Catalysis of the cleavage of hexosamine or N-acetylhexosamine residues (e.g. N-acetylglucosamine) residues from gangliosides or other glycoside oligosaccharides. 24 0.0593266426064172 0 0 1 C01D.profile.u50 nucleobase, nucleoside, nucleotide and nucleic acid transporter activity GO:0015932 Enables the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of, within or between cells. 16 0.0395510950709448 0 0 1 C01D.profile.u50 cyclosporin A binding GO:0016018 Interacting selectively with cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids. 14 0.0346072081870767 0 0 1 C01D.profile.u50 lipoxygenase activity GO:0016165 Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate. 11 0.0271913778612745 0 0 1 C01D.profile.u50 AMP binding GO:0016208 Interacting selectively with AMP, adenosine monophosphate. 19 0.0469669253967469 0 0 1 C01D.profile.u50 antioxidant activity GO:0016209 Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. 57 0.140900776190241 0 0 1 C01D.profile.u50 steroid dehydrogenase activity GO:0016229 20 0.049438868838681 0 0 1 C01D.profile.u50 channel regulator activity GO:0016247 53 0.131013002422505 0 0 1 C01D.profile.u50 channel inhibitor activity GO:0016248 13 0.0321352647451426 0 0 1 C01D.profile.u50 general RNA polymerase II transcription factor activity GO:0016251 Any function that supports basal (unregulated) transcription of genes by core RNA polymerase II. Five general transcription factors are necessary and sufficient for such basal transcription in yeast: TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBF). 38 0.0939338507934939 0 0 1 C01D.profile.u50 lysine N-methyltransferase activity GO:0016278 Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue. 21 0.051910812280615 0 0 1 C01D.profile.u50 protein-lysine N-methyltransferase activity GO:0016279 Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate. 21 0.051910812280615 0 0 1 C01D.profile.u50 alanine aminopeptidase activity GO:0016284 Catalysis of the release of an N-terminal amino acid, preferentially alanine, from an oligopeptide or polypeptide. 13 0.0321352647451426 0 0 1 C01D.profile.u50 CoA hydrolase activity GO:0016289 Catalysis of the reaction: X-CoA + H2O = X + CoA; X may be any group. 11 0.0271913778612745 0 0 1 C01D.profile.u50 palmitoyl-CoA hydrolase activity GO:0016290 Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate. 5 0.0123597172096702 0 0 1 C01D.profile.u50 acyl-CoA thioesterase activity GO:0016291 Catalysis of the reaction: acyl-CoA + H2O = corresponding fatty acid + CoA. 8 0.0197755475354724 0 0 1 C01D.profile.u50 lipase activity GO:0016298 Catalysis of the hydrolysis of a lipid or phospholipid. 96 0.237306570425669 0 0 1 C01D.profile.u50 regulator of G-protein signaling activity GO:0016299 Inhibits signal transduction the GTPase activity of G-protein alpha subunits, thereby driving them into their inactive GDP-bound form. 9 0.0222474909774064 0 0 1 C01D.profile.u50 kinase activity GO:0016301 Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 1123 2.77599248529194 4 1.44092609082814 0.302664336381521 C01D.profile.u50 1-phosphatidylinositol-3-kinase activity GO:0016303 Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate. 16 0.0395510950709448 0 0 1 C01D.profile.u50 phosphatidylinositol phosphate kinase activity GO:0016307 Catalysis of the phosphorylation of phosphatidylinositol phosphate to produce phosphatidylinositol bisphosphate. 10 0.0247194344193405 0 0 1 C01D.profile.u50 1-phosphatidylinositol-4-phosphate 5-kinase activity GO:0016308 Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. 7 0.0173036040935383 0 0 1 C01D.profile.u50 CoA-ligase activity GO:0016405 Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA. 7 0.0173036040935383 0 0 1 C01D.profile.u50 carnitine O-acyltransferase activity GO:0016406 Catalysis of the transfer of an acyl group to an oxygen atom on the carnitine molecule. 9 0.0222474909774064 0 0 1 C01D.profile.u50 acetyltransferase activity GO:0016407 Catalysis of the transfer of an acetyl group to an acceptor molecule. 81 0.200227418796658 1 4.99432098765432 0.181658299484868 C01D.profile.u50 C-acyltransferase activity GO:0016408 Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule. 23 0.0568546991644831 0 0 1 C01D.profile.u50 palmitoyltransferase activity GO:0016409 Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule. 20 0.049438868838681 0 0 1 C01D.profile.u50 N-acyltransferase activity GO:0016410 Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule. 76 0.187867701586988 1 5.3228947368421 0.171468385497323 C01D.profile.u50 acylglycerol O-acyltransferase activity GO:0016411 Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule. 13 0.0321352647451426 1 31.1184615384615 0.0316629388039029 C01D.profile.u50 S-acyltransferase activity GO:0016417 Catalysis of the transfer of an acyl group to a sulfur atom on the acceptor molecule. 9 0.0222474909774064 0 0 1 C01D.profile.u50 CoA carboxylase activity GO:0016421 12 0.0296633213032086 0 0 1 C01D.profile.u50 tRNA-pseudouridine synthase activity GO:0016439 Catalysis of the reaction: tRNA uridine = tRNA pseudouridine. Conversion of uridine in a tRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. 25 0.0617985860483512 0 0 1 C01D.profile.u50 RNA polymerase II transcription mediator activity GO:0016455 Functions to mediate the interaction of transcriptional activators with the RNA polymerase II-general RNA polymerase II transcription factor complex. 12 0.0296633213032086 0 0 1 C01D.profile.u50 pyrophosphatase activity GO:0016462 Catalysis of the hydrolysis of a pyrophosphate bond between two phosphoric groups, leaving one phosphate on each of the two fragments. 816 2.01710584861818 1 0.495759803921569 0.867291866953237 C01D.profile.u50 oxidoreductase activity GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. 874 2.16047856825036 3 1.38858123569794 0.366724252587804 C01D.profile.u50 C-C chemokine receptor activity GO:0016493 Combining with a C-C chemokine to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif. 18 0.0444949819548129 0 0 1 C01D.profile.u50 C-X-C chemokine receptor activity GO:0016494 Combining with a C-X-C chemokine to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif. 15 0.0370791516290107 0 0 1 C01D.profile.u50 protein-hormone receptor activity GO:0016500 Combining with a protein hormone to initiate a change in cell activity. 22 0.0543827557225491 0 0 1 C01D.profile.u50 nucleotide receptor activity GO:0016502 Combining with a nucleotide to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule. 22 0.0543827557225491 0 0 1 C01D.profile.u50 pheromone receptor activity GO:0016503 Combining with a pheromone to initiate a change in cell activity. 1 0.00247194344193405 0 0 1 C01D.profile.u50 protease activator activity GO:0016504 Increases the activity of a protease, any enzyme catalyzes the hydrolysis peptide bonds. 27 0.0667424729322193 0 0 1 C01D.profile.u50 apoptotic protease activator activity GO:0016505 26 0.0642705294902853 0 0 1 C01D.profile.u50 latrotoxin receptor activity GO:0016524 Combining with alpha-latrotoxin, a potent presynaptic neurotoxin, to initiate a change in cell activity. 13 0.0321352647451426 0 0 1 C01D.profile.u50 cyclin-dependent protein kinase regulator activity GO:0016538 Modulates the activity of a cyclin-dependent protein kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins. 7 0.0173036040935383 0 0 1 C01D.profile.u50 transcriptional activator activity GO:0016563 Any transcription regulator activity required for initiation or upregulation of transcription. 471 1.16428536115094 2 1.71779193205945 0.324501500124165 C01D.profile.u50 transcriptional repressor activity GO:0016564 Any transcription regulator activity that prevents or downregulates transcription. 329 0.813269392396302 0 0 1 C01D.profile.u50 specific transcriptional repressor activity GO:0016566 Any activity that stops or downregulates transcription of specific genes or sets of genes. 21 0.051910812280615 0 0 1 C01D.profile.u50 amino acid binding GO:0016597 Interacting selectively with an amino acid, organic acids containing one or more amino substituents. 18 0.0444949819548129 1 22.4744444444444 0.0435722868502822 C01D.profile.u50 oxidoreductase activity, acting on CH-OH group of donors GO:0016614 Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 133 0.328768477777228 1 3.04165413533835 0.280483267512633 C01D.profile.u50 malate dehydrogenase activity GO:0016615 Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. 12 0.0296633213032086 0 0 1 C01D.profile.u50 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. 123 0.304049043357888 1 3.28894308943089 0.262452996931924 C01D.profile.u50 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0016620 Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. 39 0.0964057942354279 0 0 1 C01D.profile.u50 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor GO:0016624 Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. 10 0.0247194344193405 0 0 1 C01D.profile.u50 oxidoreductase activity, acting on the CH-CH group of donors GO:0016627 Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 64 0.158204380283779 1 6.3209375 0.146491893854714 C01D.profile.u50 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor GO:0016628 Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP. 21 0.051910812280615 0 0 1 C01D.profile.u50 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor GO:0016634 Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces oxygen. 13 0.0321352647451426 0 0 1 C01D.profile.u50 oxidoreductase activity, acting on the CH-NH2 group of donors GO:0016638 Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 23 0.0568546991644831 0 0 1 C01D.profile.u50 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor GO:0016641 Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule. 18 0.0444949819548129 0 0 1 C01D.profile.u50 oxidoreductase activity, acting on the CH-NH group of donors GO:0016645 Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 38 0.0939338507934939 0 0 1 C01D.profile.u50 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor GO:0016646 Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP. 22 0.0543827557225491 0 0 1 C01D.profile.u50 oxidoreductase activity, acting on NADH or NADPH GO:0016651 Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 77 0.190339645028922 0 0 1 C01D.profile.u50 oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor GO:0016653 Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a heme protein. 14 0.0346072081870767 0 0 1 C01D.profile.u50 oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor GO:0016655 Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. 45 0.111237454887032 0 0 1 C01D.profile.u50 oxidoreductase activity, acting on sulfur group of donors GO:0016667 Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 14 0.0346072081870767 0 0 1 C01D.profile.u50 oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor GO:0016668 Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP. 7 0.0173036040935383 0 0 1 C01D.profile.u50 oxidoreductase activity, acting on heme group of donors GO:0016675 Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 36 0.0889899639096258 0 0 1 C01D.profile.u50 oxidoreductase activity, acting on heme group of donors, oxygen as acceptor GO:0016676 Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces oxygen. 36 0.0889899639096258 0 0 1 C01D.profile.u50 oxidoreductase activity, acting on diphenols and related substances as donors GO:0016679 Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 10 0.0247194344193405 0 0 1 C01D.profile.u50 oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor GO:0016681 Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces a cytochrome. 10 0.0247194344193405 0 0 1 C01D.profile.u50 oxidoreductase activity, acting on peroxide as acceptor GO:0016684 Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor. 39 0.0964057942354279 0 0 1 C01D.profile.u50 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen GO:0016701 Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor. 63 0.155732436841845 0 0 1 C01D.profile.u50 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0016702 Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. 63 0.155732436841845 0 0 1 C01D.profile.u50 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. 163 0.40292678103525 1 2.48184049079755 0.331972280041138 C01D.profile.u50 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors GO:0016706 Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. 36 0.0889899639096258 0 0 1 C01D.profile.u50 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen GO:0016709 Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. 35 0.0865180204676917 0 0 1 C01D.profile.u50 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. 55 0.135956889306373 0 0 1 C01D.profile.u50 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen GO:0016714 Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor. 5 0.0123597172096702 0 0 1 C01D.profile.u50 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water GO:0016717 Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water. 13 0.0321352647451426 0 0 1 C01D.profile.u50 oxidoreductase activity, oxidizing metal ions GO:0016722 Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered. 11 0.0271913778612745 0 0 1 C01D.profile.u50 oxidoreductase activity, acting on CH2 groups GO:0016725 Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 7 0.0173036040935383 0 0 1 C01D.profile.u50 transferase activity GO:0016740 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. 2063 5.09961932070994 7 1.37265147842947 0.252357234313222 C01D.profile.u50 transferase activity, transferring one-carbon groups GO:0016741 Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor). 161 0.397982894151382 0 0 1 C01D.profile.u50 hydroxymethyl-, formyl- and related transferase activity GO:0016742 9 0.0222474909774064 0 0 1 C01D.profile.u50 transferase activity, transferring acyl groups GO:0016746 Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). 207 0.511692292480348 2 3.90859903381642 0.0935845987741858 C01D.profile.u50 transferase activity, transferring groups other than amino-acyl groups GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). 194 0.479557027735205 2 4.17051546391753 0.0838774302307108 C01D.profile.u50 transferase activity, transferring amino-acyl groups GO:0016755 Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor). 19 0.0469669253967469 0 0 1 C01D.profile.u50 transferase activity, transferring glycosyl groups GO:0016757 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). 270 0.667424729322193 0 0 1 C01D.profile.u50 transferase activity, transferring hexosyl groups GO:0016758 Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). 188 0.464725367083601 0 0 1 C01D.profile.u50 transferase activity, transferring pentosyl groups GO:0016763 Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). 55 0.135956889306373 0 0 1 C01D.profile.u50 transferase activity, transferring alkyl or aryl (other than methyl) groups GO:0016765 Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). 50 0.123597172096702 0 0 1 C01D.profile.u50 transferase activity, transferring nitrogenous groups GO:0016769 Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). 46 0.113709398328966 0 0 1 C01D.profile.u50 transferase activity, transferring phosphorus-containing groups GO:0016772 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). 1266 3.12948039748851 4 1.27816745655608 0.381786418295003 C01D.profile.u50 phosphotransferase activity, alcohol group as acceptor GO:0016773 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). 993 2.45463983784051 4 1.62956696878147 0.232629883872499 C01D.profile.u50 phosphotransferase activity, nitrogenous group as acceptor GO:0016775 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a nitrogenous group (acceptor). 17 0.0420230385128788 0 0 1 C01D.profile.u50 phosphotransferase activity, phosphate group as acceptor GO:0016776 Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor). 44 0.108765511445098 0 0 1 C01D.profile.u50 diphosphotransferase activity GO:0016778 Catalysis of the transfer of a diphosphate group from one compound (donor) to a another (acceptor). 7 0.0173036040935383 0 0 1 C01D.profile.u50 nucleotidyltransferase activity GO:0016779 Catalysis of the transfer of a nucleotidyl group to a reactant. 129 0.318880704009492 0 0 1 C01D.profile.u50 phosphotransferase activity, for other substituted phosphate groups GO:0016780 Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). 16 0.0395510950709448 0 0 1 C01D.profile.u50 transferase activity, transferring sulfur-containing groups GO:0016782 Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor). 53 0.131013002422505 0 0 1 C01D.profile.u50 hydrolase activity GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3. 2507 6.19716220892866 3 0.484092540885521 0.946474365096934 C01D.profile.u50 hydrolase activity, acting on ester bonds GO:0016788 Catalysis of the hydrolysis of any ester bond. 774 1.91328422405695 1 0.52266149870801 0.85275433454693 C01D.profile.u50 thiolester hydrolase activity GO:0016790 Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A. 91 0.224946853215998 0 0 1 C01D.profile.u50 phosphoric monoester hydrolase activity GO:0016791 Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate. 328 0.810797448954368 1 1.23335365853659 0.555942502562463 C01D.profile.u50 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters GO:0016796 Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters. 25 0.0617985860483512 0 0 1 C01D.profile.u50 hydrolase activity, acting on glycosyl bonds GO:0016798 Catalysis of the hydrolysis of any glycosyl bond. 133 0.328768477777228 0 0 1 C01D.profile.u50 hydrolase activity, hydrolyzing N-glycosyl compounds GO:0016799 22 0.0543827557225491 0 0 1 C01D.profile.u50 hydrolase activity, acting on ether bonds GO:0016801 Catalysis of the hydrolysis of any ether or thioether bond, -O- or -S- respectively. 12 0.0296633213032086 0 0 1 C01D.profile.u50 dipeptidase activity GO:0016805 Catalysis of the hydrolysis of a dipeptide. 12 0.0296633213032086 0 0 1 C01D.profile.u50 dipeptidyl-peptidase and tripeptidyl-peptidase activity GO:0016806 Catalysis of the hydrolysis of N-terminal di- or tripeptides from a polypeptide chain. 12 0.0296633213032086 0 0 1 C01D.profile.u50 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016810 Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. 120 0.296633213032086 1 3.37116666666667 0.256956320975039 C01D.profile.u50 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0016811 Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. 58 0.143372719632175 1 6.9748275862069 0.133722702603265 C01D.profile.u50 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides GO:0016812 Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide. 7 0.0173036040935383 0 0 1 C01D.profile.u50 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines GO:0016813 Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2. 19 0.0469669253967469 0 0 1 C01D.profile.u50 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines GO:0016814 Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2. 30 0.0741583032580215 0 0 1 C01D.profile.u50 hydrolase activity, acting on acid anhydrides GO:0016817 Catalysis of the hydrolysis of any acid anhydride. 820 2.02699362238592 1 0.493341463414634 0.868599197481348 C01D.profile.u50 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GO:0016818 Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. 818 2.02204973550205 1 0.494547677261614 0.867947150037962 C01D.profile.u50 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0016820 Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane. 180 0.444949819548129 0 0 1 C01D.profile.u50 lyase activity GO:0016829 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. 190 0.469669253967469 0 0 1 C01D.profile.u50 carbon-carbon lyase activity GO:0016830 Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. 50 0.123597172096702 0 0 1 C01D.profile.u50 carboxy-lyase activity GO:0016831 Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. 38 0.0939338507934939 0 0 1 C01D.profile.u50 carbon-oxygen lyase activity GO:0016835 Catalysis of the breakage of a carbon-oxygen bond. 69 0.170564097493449 0 0 1 C01D.profile.u50 hydro-lyase activity GO:0016836 Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. 60 0.148316606516043 0 0 1 C01D.profile.u50 carbon-nitrogen lyase activity GO:0016840 Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99). 11 0.0271913778612745 0 0 1 C01D.profile.u50 carbon-sulfur lyase activity GO:0016846 Catalysis of the elimination of H2S or substituted H2S. 12 0.0296633213032086 0 0 1 C01D.profile.u50 1-aminocyclopropane-1-carboxylate synthase activity GO:0016847 Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine. 5 0.0123597172096702 0 0 1 C01D.profile.u50 phosphorus-oxygen lyase activity GO:0016849 31 0.0766302466999555 0 0 1 C01D.profile.u50 isomerase activity GO:0016853 Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. 189 0.467197310525535 1 2.14042328042328 0.373605996032068 C01D.profile.u50 racemase and epimerase activity GO:0016854 Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule. 14 0.0346072081870767 0 0 1 C01D.profile.u50 racemase and epimerase activity, acting on carbohydrates and derivatives GO:0016857 Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. 6 0.0148316606516043 0 0 1 C01D.profile.u50 cis-trans isomerase activity GO:0016859 Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or trans to one another when they lie respectively on the same or on opposite sides of a reference plane identifiable as common among stereoisomers. 58 0.143372719632175 0 0 1 C01D.profile.u50 intramolecular oxidoreductase activity GO:0016860 Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears. 56 0.138428832748307 1 7.22392857142857 0.12942399295915 C01D.profile.u50 intramolecular oxidoreductase activity, interconverting aldoses and ketoses GO:0016861 8 0.0197755475354724 0 0 1 C01D.profile.u50 intramolecular oxidoreductase activity, interconverting keto- and enol-groups GO:0016862 18 0.0444949819548129 1 22.4744444444444 0.0435722868502822 C01D.profile.u50 intramolecular oxidoreductase activity, transposing C=C bonds GO:0016863 18 0.0444949819548129 0 0 1 C01D.profile.u50 intramolecular oxidoreductase activity, transposing S-S bonds GO:0016864 17 0.0420230385128788 1 23.7964705882353 0.0412021928988779 C01D.profile.u50 intramolecular transferase activity GO:0016866 Catalysis of the transfer of a functional group from one position to another within a single molecule. 38 0.0939338507934939 0 0 1 C01D.profile.u50 intramolecular transferase activity, phosphotransferases GO:0016868 Catalysis of the transfer of a phosphate group from one position to another within a single molecule. 7 0.0173036040935383 0 0 1 C01D.profile.u50 ligase activity GO:0016874 Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. 425 1.05057596282197 1 0.951858823529412 0.65071832437651 C01D.profile.u50 ligase activity, forming carbon-oxygen bonds GO:0016875 Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. 54 0.133484945864439 0 0 1 C01D.profile.u50 ligase activity, forming aminoacyl-tRNA and related compounds GO:0016876 Catalysis of the ligation of two substances via a carbon-oxygen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate, to form aminoacyl-tRNA or a related compound. 54 0.133484945864439 0 0 1 C01D.profile.u50 ligase activity, forming carbon-sulfur bonds GO:0016877 Catalysis of the ligation of two substances via a carbon-sulfur bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. 23 0.0568546991644831 0 0 1 C01D.profile.u50 acid-thiol ligase activity GO:0016878 Catalysis of the ligation of an acid and a thiol via a carbon-sulfur bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. 8 0.0197755475354724 0 0 1 C01D.profile.u50 ligase activity, forming carbon-nitrogen bonds GO:0016879 Catalysis of the ligation of two substances via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. 266 0.657536955554457 1 1.52082706766917 0.482295671670703 C01D.profile.u50 acid-amino acid ligase activity GO:0016881 Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. 222 0.548771444109359 1 1.82225225225225 0.422733259034578 C01D.profile.u50 carbon-nitrogen ligase activity, with glutamine as amido-N-donor GO:0016884 Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction. 9 0.0222474909774064 0 0 1 C01D.profile.u50 ligase activity, forming carbon-carbon bonds GO:0016885 Catalysis of the ligation of two substances via a carbon-carbon bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. 13 0.0321352647451426 0 0 1 C01D.profile.u50 ligase activity, forming phosphoric ester bonds GO:0016886 Catalysis of the ligation of two substances via a phosphoric ester bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate. 10 0.0247194344193405 0 0 1 C01D.profile.u50 ATPase activity GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction. 431 1.06540762347357 1 0.93860788863109 0.655866842674364 C01D.profile.u50 endoribonuclease activity, producing 5'-phosphomonoesters GO:0016891 Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. 30 0.0741583032580215 0 0 1 C01D.profile.u50 endoribonuclease activity, producing 3'-phosphomonoesters GO:0016892 Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters. 15 0.0370791516290107 0 0 1 C01D.profile.u50 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters GO:0016893 Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters. 31 0.0766302466999555 0 0 1 C01D.profile.u50 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters GO:0016894 Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters. 18 0.0444949819548129 0 0 1 C01D.profile.u50 exodeoxyribonuclease activity, producing 5'-phosphomonoesters GO:0016895 Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters. 12 0.0296633213032086 0 0 1 C01D.profile.u50 exoribonuclease activity, producing 5'-phosphomonoesters GO:0016896 Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters. 15 0.0370791516290107 0 0 1 C01D.profile.u50 oxidoreductase activity, acting on the aldehyde or oxo group of donors GO:0016903 Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. 51 0.126069115538636 0 0 1 C01D.profile.u50 SAP kinase activity GO:0016909 Catalysis of the phosphorylation of proteins. A family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. Strongly activated by stress signals such as heat or osmotic shock, DNA-damaging agents, inhibitors of protein synthesis and pro-inflammatory cytokines. 14 0.0346072081870767 0 0 1 C01D.profile.u50 GABA receptor activity GO:0016917 Combining with gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to initiate a change in cell activity. 27 0.0667424729322193 1 14.982962962963 0.0646412195945478 C01D.profile.u50 retinal binding GO:0016918 Interacting selectively with retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina. 8 0.0197755475354724 0 0 1 C01D.profile.u50 transcription initiation factor activity GO:0016986 10 0.0247194344193405 0 0 1 C01D.profile.u50 alpha-sialidase activity GO:0016997 Catalysis of the hydrolysis of alpha-glycosidic linkages in oligo- or poly(sialic) acids. 5 0.0123597172096702 0 0 1 C01D.profile.u50 activin receptor activity GO:0017002 Combining with activin, one of two gonadal glycoproteins related to transforming growth factor beta, to initiate a change in cell activity. 10 0.0247194344193405 0 0 1 C01D.profile.u50 Ras GTPase binding GO:0017016 Interacting selectively with any member of the Ras superfamily of monomeric GTPases. 89 0.22000296633213 0 0 1 C01D.profile.u50 MAP kinase phosphatase activity GO:0017017 Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; activity is dependent on the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK). 14 0.0346072081870767 0 0 1 C01D.profile.u50 myosin binding GO:0017022 Interacting selectively with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments. 30 0.0741583032580215 0 0 1 C01D.profile.u50 ceramidase activity GO:0017040 Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine. 9 0.0222474909774064 0 0 1 C01D.profile.u50 Rho GTPase binding GO:0017048 Interacting selectively with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton. 29 0.0716863598160874 0 0 1 C01D.profile.u50 snRNA binding GO:0017069 Interacting selectively with a small nuclear RNA (snRNA). 7 0.0173036040935383 0 0 1 C01D.profile.u50 purine nucleotide binding GO:0017076 Interacting selectively with purine nucleotides, any compound consisting of a purine nucleoside esterified with (ortho)phosphate. 2328 5.75468433282247 7 1.21640034364261 0.354312364333088 C01D.profile.u50 nucleoside-diphosphatase activity GO:0017110 Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleotide + phosphate. 9 0.0222474909774064 0 0 1 C01D.profile.u50 nucleoside-triphosphatase activity GO:0017111 Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate. 787 1.9454194888021 1 0.514027954256671 0.857416565041311 C01D.profile.u50 SH3 domain binding GO:0017124 Interacting selectively with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. 21 0.051910812280615 0 0 1 C01D.profile.u50 Rab GTPase binding GO:0017137 Interacting selectively with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases. 23 0.0568546991644831 0 0 1 C01D.profile.u50 sodium:dicarboxylate symporter activity GO:0017153 Catalysis of the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). 15 0.0370791516290107 0 0 1 C01D.profile.u50 semaphorin receptor activity GO:0017154 13 0.0321352647451426 0 0 1 C01D.profile.u50 CDP-alcohol phosphatidyltransferase activity GO:0017169 Catalysis of the reaction: CDP + alcohol = CMP + phosphatidyl alcohol. 9 0.0222474909774064 0 0 1 C01D.profile.u50 serine hydrolase activity GO:0017171 Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). 182 0.449893706431997 0 0 1 C01D.profile.u50 histone-lysine N-methyltransferase activity GO:0018024 Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives. 21 0.051910812280615 0 0 1 C01D.profile.u50 guanyl nucleotide binding GO:0019001 Interacting selectively with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate. 460 1.13709398328966 0 0 1 C01D.profile.u50 GMP binding GO:0019002 Interacting selectively with GMP, guanosine monophosphate. 11 0.0271913778612745 0 0 1 C01D.profile.u50 DNA N-glycosylase activity GO:0019104 Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. 19 0.0469669253967469 0 0 1 C01D.profile.u50 transmembrane receptor protein phosphatase activity GO:0019198 The catalysis of phosphate removal from a phosphotyrosine using aspartic acid as a nucleophile in a metal-dependent manner. 32 0.0791021901418896 0 0 1 C01D.profile.u50 transmembrane receptor protein kinase activity GO:0019199 163 0.40292678103525 1 2.48184049079755 0.331972280041138 C01D.profile.u50 carbohydrate kinase activity GO:0019200 Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule. 34 0.0840460770257577 0 0 1 C01D.profile.u50 nucleotide kinase activity GO:0019201 Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate. 33 0.0815741335838236 0 0 1 C01D.profile.u50 carbohydrate phosphatase activity GO:0019203 Catalysis of the reaction: carbohydrate phosphate + H2O = carbohydrate + phosphate. 8 0.0197755475354724 0 0 1 C01D.profile.u50 nucleobase, nucleoside, nucleotide kinase activity GO:0019205 Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate. 54 0.133484945864439 0 0 1 C01D.profile.u50 nucleoside kinase activity GO:0019206 Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate. 20 0.049438868838681 0 0 1 C01D.profile.u50 kinase regulator activity GO:0019207 Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 123 0.304049043357888 0 0 1 C01D.profile.u50 phosphatase regulator activity GO:0019208 Modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. 77 0.190339645028922 0 0 1 C01D.profile.u50 kinase activator activity GO:0019209 Increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 19 0.0469669253967469 0 0 1 C01D.profile.u50 kinase inhibitor activity GO:0019210 Stops, prevents or reduces the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. 65 0.160676323725713 0 0 1 C01D.profile.u50 phosphatase inhibitor activity GO:0019212 Stops, prevents or reduces the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. 37 0.0914619073515598 0 0 1 C01D.profile.u50 deacetylase activity GO:0019213 Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule. 18 0.0444949819548129 0 0 1 C01D.profile.u50 deaminase activity GO:0019239 Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3). 26 0.0642705294902853 0 0 1 C01D.profile.u50 small conjugating protein-specific protease activity GO:0019783 Catalysis of the hydrolysis of various forms of polymeric ubiquitin or ubiquitin-like sequences (e.g. APG8, ISG15, NEDD8, SUMO). Will remove ubiquitin-like sequences from larger leaving groups. 80 0.197755475354724 0 0 1 C01D.profile.u50 small conjugating protein ligase activity GO:0019787 Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. 201 0.496860631828744 0 0 1 C01D.profile.u50 procollagen-proline dioxygenase activity GO:0019798 Catalysis of the transfer of a hydroxyl group from 2-oxoglutarate to a prolyl residue in a collagen molecule. 7 0.0173036040935383 0 0 1 C01D.profile.u50 oxygen binding GO:0019825 Interacting selectively with oxygen (O2). 56 0.138428832748307 0 0 1 C01D.profile.u50 cation-transporting ATPase activity GO:0019829 Catalysis of the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in). 86 0.212587136006328 0 0 1 C01D.profile.u50 growth factor binding GO:0019838 Interacting selectively with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate. 114 0.281801552380482 0 0 1 C01D.profile.u50 isoprenoid binding GO:0019840 Interacting selectively with any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. 13 0.0321352647451426 0 0 1 C01D.profile.u50 retinol binding GO:0019841 Interacting selectively with retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation. 6 0.0148316606516043 0 0 1 C01D.profile.u50 vitamin binding GO:0019842 Interacting selectively with a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. 94 0.232362683541801 0 0 1 C01D.profile.u50 rRNA binding GO:0019843 Interacting selectively with ribosomal RNA. 22 0.0543827557225491 0 0 1 C01D.profile.u50 IgG binding GO:0019864 Interacting selectively with an immunoglobulin of an IgG isotype. 8 0.0197755475354724 0 0 1 C01D.profile.u50 immunoglobulin binding GO:0019865 Interacting selectively with an immunoglobulin. 23 0.0568546991644831 0 0 1 C01D.profile.u50 protein kinase regulator activity GO:0019887 Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein. 103 0.254610174519207 0 0 1 C01D.profile.u50 protein phosphatase regulator activity GO:0019888 Modulation of the activity of a protein phosphatase enzyme. 72 0.177979927819252 0 0 1 C01D.profile.u50 kinesin binding GO:0019894 Interacting selectively and stoichiometrically with kinesin, a cytoplasmic protein responsible for moving vesicles and organelles towards the distal end of microtubules. 16 0.0395510950709448 0 0 1 C01D.profile.u50 enzyme binding GO:0019899 Interacting selectively with any enzyme. 411 1.01596875463489 0 0 1 C01D.profile.u50 kinase binding GO:0019900 Interacting selectively with a kinase, any enzyme that catalyzes the transfer of a phosphate group. 149 0.368319572848173 0 0 1 C01D.profile.u50 protein kinase binding GO:0019901 Interacting selectively with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. 130 0.321352647451426 0 0 1 C01D.profile.u50 phosphatase binding GO:0019902 Interacting selectively with any phosphatase. 32 0.0791021901418896 0 0 1 C01D.profile.u50 protein phosphatase binding GO:0019903 Interacting selectively with any protein phosphatase. 20 0.049438868838681 0 0 1 C01D.profile.u50 protein domain specific binding GO:0019904 Interacting selectively with a specific domain of a protein. 133 0.328768477777228 1 3.04165413533835 0.280483267512633 C01D.profile.u50 syntaxin binding GO:0019905 Interacting selectively with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse. 14 0.0346072081870767 0 0 1 C01D.profile.u50 cytokine binding GO:0019955 Interacting selectively with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. 110 0.271913778612745 1 3.67763636363636 0.238336491885323 C01D.profile.u50 chemokine binding GO:0019956 Interacting selectively with a chemokine, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions. 35 0.0865180204676917 0 0 1 C01D.profile.u50 C-C chemokine binding GO:0019957 Interacting selectively with a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif. 18 0.0444949819548129 0 0 1 C01D.profile.u50 C-X-C chemokine binding GO:0019958 Interacting selectively with a C-X-C chemokine; C-X-C chemokines have a single amino acid between the first two cysteines of the characteristic four cysteine motif. 16 0.0395510950709448 0 0 1 C01D.profile.u50 interleukin binding GO:0019965 Interacting selectively with an interleukin. 50 0.123597172096702 0 0 1 C01D.profile.u50 interleukin-1 binding GO:0019966 Interacting selectively with interleukin-1. 13 0.0321352647451426 0 0 1 C01D.profile.u50 diacylglycerol binding GO:0019992 Interacting selectively with diacylglycerol, a diester of glycerol and two fatty acids. 83 0.205171305680526 1 4.87397590361446 0.185699087804022 C01D.profile.u50 heme binding GO:0020037 Interacting selectively with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. 145 0.358431799080437 0 0 1 C01D.profile.u50 extracellular matrix structural constituent conferring compression resistance GO:0030021 A constituent of the extracellular matrix that enables the matrix to resist compressive forces; often a proteoglycan. 7 0.0173036040935383 0 0 1 C01D.profile.u50 manganese ion binding GO:0030145 Interacting selectively with manganese (Mn) ions. 166 0.410342611361052 0 0 1 C01D.profile.u50 molybdenum ion binding GO:0030151 Interacting selectively with molybdenum (Mo) ions. 9 0.0222474909774064 0 0 1 C01D.profile.u50 receptor signaling complex scaffold activity GO:0030159 Functions to provide a physical suport for the assembly of a multiprotein receptor signaling complex. 40 0.098877737677362 0 0 1 C01D.profile.u50 PDZ domain binding GO:0030165 Interacting selectively with a PDZ domain of a protein, a domain found in diverse signaling proteins. 24 0.0593266426064172 1 16.8558333333333 0.0576703226918033 C01D.profile.u50 low-density lipoprotein binding GO:0030169 Interacting selectively with low-density lipoprotein, one of the classes of lipoproteins found in blood plasma in many animals (data normally relate to humans). 20 0.049438868838681 1 20.227 0.0482949130209605 C01D.profile.u50 pyridoxal phosphate binding GO:0030170 Interacting selectively with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. 20 0.049438868838681 0 0 1 C01D.profile.u50 chaperone regulator activity GO:0030188 Modulates the activity of a molecular chaperone. 7 0.0173036040935383 1 57.7914285714286 0.0171758108653961 C01D.profile.u50 lipoprotein receptor activity GO:0030228 Combining with a lipoprotein to initiate a change in cell activity. A lipoprotein is any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids; the lipid may be triacylglycerol, cholesterol, or phospholipid, or a combination of these. 16 0.0395510950709448 1 25.28375 0.0388262256909156 C01D.profile.u50 enzyme regulator activity GO:0030234 Modulates the activity of an enzyme. 1023 2.52879814109853 2 0.79088954056696 0.7189428441888 C01D.profile.u50 carbohydrate binding GO:0030246 Interacting selectively with any carbohydrate. 357 0.882483808770455 0 0 1 C01D.profile.u50 polysaccharide binding GO:0030247 Interacting selectively with any polysaccharide. 174 0.430118158896524 0 0 1 C01D.profile.u50 guanylate cyclase regulator activity GO:0030249 Modulates the activity of guanylate cyclase. 7 0.0173036040935383 0 0 1 C01D.profile.u50 guanylate cyclase activator activity GO:0030250 Increases the activity of guanylate cyclase. 6 0.0148316606516043 0 0 1 C01D.profile.u50 LIM domain binding GO:0030274 Interacting selectively with a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions. 8 0.0197755475354724 0 0 1 C01D.profile.u50 clathrin binding GO:0030276 Interacting selectively with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles. 11 0.0271913778612745 0 0 1 C01D.profile.u50 structural constituent of epidermis GO:0030280 The action of a molecule that contributes to the structural integrity of an epidermal cutaneous structure. 9 0.0222474909774064 0 0 1 C01D.profile.u50 protein kinase activator activity GO:0030295 Increases the activity of a protein kinase, an enzyme which phosphorylates a protein. 14 0.0346072081870767 0 0 1 C01D.profile.u50 estrogen receptor binding GO:0030331 Interacting selectively with an estrogen receptor. 6 0.0148316606516043 0 0 1 C01D.profile.u50 fibroblast growth factor receptor antagonist activity GO:0030353 Interacts with the fibroblast growth factor receptor to reduce the action of another ligand, the agonist. 10 0.0247194344193405 0 0 1 C01D.profile.u50 ligand-dependent nuclear receptor transcription coactivator activity GO:0030374 21 0.051910812280615 0 0 1 C01D.profile.u50 protease inhibitor activity GO:0030414 Stops, prevents or reduces the activity of a protease, any enzyme catalyzes the hydrolysis peptide bonds. 157 0.388095120383646 0 0 1 C01D.profile.u50 thiol-disulfide exchange intermediate activity GO:0030508 Functions as an exchange intermediate in thiol-disulfide exchange reactions. 8 0.0197755475354724 0 0 1 C01D.profile.u50 snoRNA binding GO:0030515 Interacting selectively with small nucleolar RNA. 8 0.0197755475354724 0 0 1 C01D.profile.u50 transcription regulator activity GO:0030528 Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. 1862 4.6027586888812 7 1.52082706766917 0.182106910606375 C01D.profile.u50 receptor regulator activity GO:0030545 The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is changed. 22 0.0543827557225491 0 0 1 C01D.profile.u50 receptor inhibitor activity GO:0030547 The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is decreased. 15 0.0370791516290107 0 0 1 C01D.profile.u50 cyclic nucleotide binding GO:0030551 Interacting selectively with a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. 28 0.0692144163741534 0 0 1 C01D.profile.u50 cAMP binding GO:0030552 Interacting selectively with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate). 17 0.0420230385128788 0 0 1 C01D.profile.u50 cGMP binding GO:0030553 Interacting selectively with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate). 11 0.0271913778612745 0 0 1 C01D.profile.u50 adenyl nucleotide binding GO:0030554 Interacting selectively with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate. 1902 4.70163642655856 7 1.48884332281809 0.195398724382094 C01D.profile.u50 neurotransmitter receptor activity GO:0030594 Combining with a neurotransmitter to initiate a change in cell activity. 105 0.259554061403075 1 3.8527619047619 0.228852329425735 C01D.profile.u50 protein binding, bridging GO:0030674 Interacting selectively with two or more protein molecules, or a protein and another macromolecule or complex, simultaneously, thereby physically linking the bound proteins or complexes to each other. 127 0.313936817125624 0 0 1 C01D.profile.u50 caspase activity GO:0030693 Catalysis of the hydrolysis of a peptide bond on the carboxyl side of an aspartate residue. 40 0.098877737677362 0 0 1 C01D.profile.u50 GTPase regulator activity GO:0030695 Modulates the rate of GTP hydrolysis by a GTPase. 482 1.19147673901221 2 1.67858921161826 0.334375638199422 C01D.profile.u50 GTP-dependent protein binding GO:0030742 Interacting selectively with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of GTP. 11 0.0271913778612745 0 0 1 C01D.profile.u50 potassium ion binding GO:0030955 Interacting selectively with potassium (K+) ions. 127 0.313936817125624 0 0 1 C01D.profile.u50 mismatched DNA binding GO:0030983 Interacting selectively with double-stranded DNA containing one or more mismatches. 26 0.0642705294902853 0 0 1 C01D.profile.u50 heat shock protein binding GO:0031072 Interacting selectvely with a heat shock protein, any protein synthesized or activated in response to heat shock. 66 0.163148267167647 1 6.12939393939394 0.15070632602094 C01D.profile.u50 phosphopantetheine binding GO:0031177 Interacting selectizely with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate). 4 0.00988777376773619 0 0 1 C01D.profile.u50 RNA splicing factor activity, transesterification mechanism GO:0031202 An activity which binds RNA and functions to assist splicing of substrate RNA(s) by facilitating the formation and stabilization of a catalytic conformation in which the splice junctions of the RNA(s) to be spliced are positioned for a transesterification reaction that occurs between two sites within the RNA(s) to be spliced. 38 0.0939338507934939 0 0 1 C01D.profile.u50 small GTPase binding GO:0031267 Interacting selectively with a small monomeric GTPase. 102 0.252138231077273 0 0 1 C01D.profile.u50 sodium ion binding GO:0031402 Interacting selectively with sodium ions (Na+). 102 0.252138231077273 0 0 1 C01D.profile.u50 chloride ion binding GO:0031404 Interacting selectively with chloride ions (Cl-). 80 0.197755475354724 2 10.1135 0.0169957869124358 C01D.profile.u50 lipoic acid binding GO:0031405 Interacting selectively with lipoic acid, 1,2-dithiolane-3-pentanoic acid. 8 0.0197755475354724 0 0 1 C01D.profile.u50 carboxylic acid binding GO:0031406 Interacting selectively with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). 12 0.0296633213032086 0 0 1 C01D.profile.u50 L-ascorbic acid binding GO:0031418 Interacting selectivzely with L-ascorbic acid, a six-carbon carbohydrate-like compound found in fruit and vegetables. It has vitamin C activity in humans and guinea pigs. 19 0.0469669253967469 0 0 1 C01D.profile.u50 alkali metal ion binding GO:0031420 Interacting selectively with any alkali metal ion; alkali metals are those elements in group Ia of the periodic table, with the exception of hydrogen. 213 0.526523953131952 0 0 1 C01D.profile.u50 peptidyl-proline dioxygenase activity GO:0031543 Catalysis of the transfer of a hydroxyl group from 2-oxoglutarate to a prolyl residue in a protein. 7 0.0173036040935383 0 0 1 C01D.profile.u50 small conjugating protein binding GO:0032182 Interacting selectively and non-covalently with a small conjugating protein such as ubiquitin or a ubiquitin-like protein. 28 0.0692144163741534 0 0 1 C01D.profile.u50 MHC class I receptor activity GO:0032393 Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules. 32 0.0791021901418896 0 0 1 C01D.profile.u50 MHC class II receptor activity GO:0032395 Combining with an MHC class II protein complex to initiate a change in cellular activity. 30 0.0741583032580215 0 0 1 C01D.profile.u50 protein complex binding GO:0032403 Interacting selectively with any protein complex (a complex of two or more proteins that may include other nonprotein molecules). 147 0.363375685964305 0 0 1 C01D.profile.u50 mismatch repair complex binding GO:0032404 Interacting selectively with a mismatch repair complex. 11 0.0271913778612745 0 0 1 C01D.profile.u50 MutLalpha complex binding GO:0032405 Interacting selectively with the mismatch repair complex MutLalpha. 9 0.0222474909774064 0 0 1 C01D.profile.u50 demethylase activity GO:0032451 Catalysis of the removal of a methyl group from a substrate. 7 0.0173036040935383 0 0 1 C01D.profile.u50 tumor necrosis factor receptor superfamily binding GO:0032813 Interacting selectively with any member of the tumor necrosis factor receptor superfamily. 32 0.0791021901418896 0 0 1 C01D.profile.u50 sterol binding GO:0032934 Interacting selectively with a sterol, any steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol. 18 0.0444949819548129 0 0 1 C01D.profile.u50 protein complex scaffold GO:0032947 Functions to provide a physical suport for the assembly of a multiprotein receptor signaling complex. 40 0.098877737677362 0 0 1 C01D.profile.u50 phosphoinositide 3-kinase activity GO:0035004 Catalysis of the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring to generate the 3-phosphoinositides: phosphatidylinositol-3-phosphate [PI(3)P], phosphatidylinositol-3,4-bisphosphate [PI(3,4)P2] and phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3]. 16 0.0395510950709448 0 0 1 C01D.profile.u50 phosphoinositide 3-kinase regulator activity GO:0035014 Modulates the activity of any of the phosphoinositide 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. 8 0.0197755475354724 0 0 1 C01D.profile.u50 histone acetyltransferase binding GO:0035035 Interacting selectively with the enzyme histone acetyltransferase. 13 0.0321352647451426 0 0 1 C01D.profile.u50 phosphoinositide binding GO:0035091 Interacting selectively with any inositol-containing glycerophospholipid. 222 0.548771444109359 1 1.82225225225225 0.422733259034578 C01D.profile.u50 dopamine binding GO:0035240 Interacting selectively with dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine. 9 0.0222474909774064 0 0 1 C01D.profile.u50 UDP-galactosyltransferase activity GO:0035250 Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule. 27 0.0667424729322193 0 0 1 C01D.profile.u50 UDP-glucosyltransferase activity GO:0035251 Catalysis of the transfer of a glucosyl group from UDP-glucose to an acceptor molecule. 12 0.0296633213032086 0 0 1 C01D.profile.u50 nuclear hormone receptor binding GO:0035257 Interacting selectively with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell. 70 0.173036040935383 1 5.77914285714286 0.159072863337331 C01D.profile.u50 steroid hormone receptor binding GO:0035258 Interacting selectively with a steroid hormone receptor. 48 0.118653285212834 0 0 1 C01D.profile.u50 neurexin binding GO:0042043 Interacting selectively with neurexins, synaptic cell surface proteins related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals. 4 0.00988777376773619 0 0 1 C01D.profile.u50 histone methyltransferase activity GO:0042054 Catalysis of the transfer of a methyl group (CH3-) to a histone. 29 0.0716863598160874 0 0 1 C01D.profile.u50 chemoattractant activity GO:0042056 Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal. 4 0.00988777376773619 0 0 1 C01D.profile.u50 telomeric DNA binding GO:0042162 Interacting selectively with telomere-associated DNA, usually characterized by highly repetitive sequences. 13 0.0321352647451426 0 0 1 C01D.profile.u50 neurotransmitter binding GO:0042165 Interacting selectively with a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. 110 0.271913778612745 1 3.67763636363636 0.238336491885323 C01D.profile.u50 acetylcholine binding GO:0042166 Interacting selectively with acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. 27 0.0667424729322193 0 0 1 C01D.profile.u50 SH2 domain binding GO:0042169 Interacting selectively with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class. 29 0.0716863598160874 0 0 1 C01D.profile.u50 peptide binding GO:0042277 Interacting selectively with peptides, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds. 254 0.627873634251248 0 0 1 C01D.profile.u50 MHC protein binding GO:0042287 Interacting selectively with major histocompatibility complex molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. 31 0.0766302466999555 1 13.0496774193548 0.0738555990020986 C01D.profile.u50 MHC class I protein binding GO:0042288 Interacting selectively with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. 16 0.0395510950709448 0 0 1 C01D.profile.u50 chemokine receptor binding GO:0042379 Interacting selectively with any chemokine receptor. 56 0.138428832748307 0 0 1 C01D.profile.u50 histone binding GO:0042393 Interacting selectively with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity. 19 0.0469669253967469 0 0 1 C01D.profile.u50 hormone binding GO:0042562 Interacting selectively with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone. 26 0.0642705294902853 0 0 1 C01D.profile.u50 lipid phosphatase activity GO:0042577 Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate. 28 0.0692144163741534 0 0 1 C01D.profile.u50 phosphoric ester hydrolase activity GO:0042578 Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. 428 1.05799179314777 1 0.94518691588785 0.653302140433057 C01D.profile.u50 peptide antigen binding GO:0042605 Interacting selectively with an antigen peptide, a fragment of a foreign protein derived by proteolysis within the cell. 29 0.0716863598160874 0 0 1 C01D.profile.u50 ATPase activity, coupled GO:0042623 Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive some other reaction, for example ion transport across a membrane. 377 0.931922677609136 1 1.07305039787798 0.606658233192124 C01D.profile.u50 ATPase activity, coupled to transmembrane movement of ions GO:0042625 Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. 125 0.308992930241756 0 0 1 C01D.profile.u50 ATPase activity, coupled to transmembrane movement of substances GO:0042626 Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the transport of a substance across a membrane. 178 0.440005932664261 0 0 1 C01D.profile.u50 elastase activity GO:0042708 Catalysis of the hydrolysis of elastin. 8 0.0197755475354724 0 0 1 C01D.profile.u50 identical protein binding GO:0042802 Interacting selectively with an identical protein or proteins. 463 1.14450981361546 5 4.36868250539957 0.00631303366660989 C01D.profile.u50 protein homodimerization activity GO:0042803 Interacting selectively with an identical protein to form a homodimer. 223 0.551243387551293 1 1.81408071748879 0.424160229769154 C01D.profile.u50 vitamin D receptor binding GO:0042809 Interacting selectively with the vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes. 6 0.0148316606516043 0 0 1 C01D.profile.u50 Wnt receptor activity GO:0042813 Combining with a member of the Wnt-family of signaling molecules to initiate a change in cell activity. 11 0.0271913778612745 0 0 1 C01D.profile.u50 histone deacetylase binding GO:0042826 Interacting selectively with the enzyme histone deacetylase. 13 0.0321352647451426 0 0 1 C01D.profile.u50 peptidoglycan binding GO:0042834 Interacting selectively, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls. 9 0.0222474909774064 0 0 1 C01D.profile.u50 antibiotic transporter activity GO:0042895 The directed movement of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms, into, out of, within or between cells. 3 0.00741583032580215 0 0 1 C01D.profile.u50 neuropeptide binding GO:0042923 Interacting selectively and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators). 39 0.0964057942354279 0 0 1 C01D.profile.u50 gamma-tubulin binding GO:0043015 Interacting selectively with the microtubule constituent protein gamma-tubulin. 9 0.0222474909774064 1 44.9488888888889 0.0220287769316943 C01D.profile.u50 ribonucleoprotein binding GO:0043021 Interacting selectively with any complex of RNA and protein. 17 0.0420230385128788 0 0 1 C01D.profile.u50 ribosome binding GO:0043022 Interacting selectively with any part of a ribosome. 9 0.0222474909774064 0 0 1 C01D.profile.u50 caspase inhibitor activity GO:0043027 Stops, prevents or reduces the activity of a caspase, any of a group of cysteine proteases involved in apoptosis. 8 0.0197755475354724 0 0 1 C01D.profile.u50 caspase regulator activity GO:0043028 Modulates the activity of a caspase, any of a group of cysteine proteases involved in apoptosis. 32 0.0791021901418896 0 0 1 C01D.profile.u50 tumor necrosis factor binding GO:0043120 Interacting selectively with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages. 12 0.0296633213032086 0 0 1 C01D.profile.u50 ubiquitin binding GO:0043130 Interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation. 22 0.0543827557225491 0 0 1 C01D.profile.u50 ion binding GO:0043167 Interacting selectively with ions, charged atoms or groups of atoms. 4408 10.8963266920453 16 1.46838475499093 0.0869161770721065 C01D.profile.u50 anion binding GO:0043168 Interacting selectively with anions, charged atoms or groups of atoms with a net negative charge. 80 0.197755475354724 2 10.1135 0.0169957869124358 C01D.profile.u50 cation binding GO:0043169 Interacting selectively with cations, charged atoms or groups of atoms with a net positive charge. 3965 9.8012557472685 11 1.1223051702396 0.392081080132213 C01D.profile.u50 amine binding GO:0043176 Interacting selectively with any organic compound that is weakly basic in character and contains an amino or a substituted amino group. 48 0.118653285212834 1 8.42791666666667 0.11201477926423 C01D.profile.u50 ATPase activity, coupled to movement of substances GO:0043492 Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive the transport of a substance. 180 0.444949819548129 0 0 1 C01D.profile.u50 ADP binding GO:0043531 Interacting selectively with ADP, adenosine 5'-diphosphate. 17 0.0420230385128788 1 23.7964705882353 0.0412021928988779 C01D.profile.u50 insulin receptor substrate binding GO:0043560 Interacting selectively with any of the insulin receptor substrate (IRS) proteins, adaptor proteins that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex. 12 0.0296633213032086 0 0 1 C01D.profile.u50 sequence-specific DNA binding GO:0043565 Interacting selectively with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. 613 1.51530132990557 3 1.97980424143556 0.19485223013042 C01D.profile.u50 structure-specific DNA binding GO:0043566 Interacting selectively with DNA of a specific structure or configuration e.g. triplex DNA binding or bent DNA binding. 142 0.351015968754635 0 0 1 C01D.profile.u50 purinergic nucleotide receptor activity, G-protein coupled GO:0045028 22 0.0543827557225491 0 0 1 C01D.profile.u50 bioactive lipid receptor activity GO:0045125 12 0.0296633213032086 0 0 1 C01D.profile.u50 translation regulator activity GO:0045182 Any substance involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome. 132 0.326296534335294 0 0 1 C01D.profile.u50 cadherin binding GO:0045296 Interacting selectively with cadherin, a type I membrane protein involved in cell adhesion. 13 0.0321352647451426 0 0 1 C01D.profile.u50 protein phosphorylated amino acid binding GO:0045309 Interacting selectively with a phosphorylated amino acid residue within a protein. 9 0.0222474909774064 0 0 1 C01D.profile.u50 inositol trisphosphate phosphatase activity GO:0046030 Catalysis of the removal of one of the three phosphate groups of an inositol trisphosphate. 9 0.0222474909774064 0 0 1 C01D.profile.u50 SMAD binding GO:0046332 Interacting selectively with a SMAD signaling protein. 20 0.049438868838681 0 0 1 C01D.profile.u50 glucosyltransferase activity GO:0046527 Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. 13 0.0321352647451426 0 0 1 C01D.profile.u50 cadmium ion binding GO:0046870 Interacting selectively with cadmium (Cd) ions. 9 0.0222474909774064 2 89.8977777777778 0.000217454615158993 C01D.profile.u50 metal ion binding GO:0046872 Interacting selectively with any metal ion. 4298 10.6244129134325 14 1.31771986970684 0.184924699765673 C01D.profile.u50 metal ion transporter activity GO:0046873 Enables the directed movement of metal ions into, out of, within or between cells. 93 0.229890740099867 0 0 1 C01D.profile.u50 ephrin receptor binding GO:0046875 Interacting selectively with an ephrin receptor. 11 0.0271913778612745 1 36.7763636363636 0.0268577801367799 C01D.profile.u50 tetrapyrrole binding GO:0046906 Interacting selectively with a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position. 145 0.358431799080437 0 0 1 C01D.profile.u50 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer GO:0046912 Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer. 11 0.0271913778612745 0 0 1 C01D.profile.u50 transition metal ion binding GO:0046914 Interacting selectively with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. 2770 6.84728333415732 9 1.31438989169675 0.251044319188508 C01D.profile.u50 transition metal ion transporter activity GO:0046915 Enables the directed movement of transition metal ions into, out of, within or between cells. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. 28 0.0692144163741534 0 0 1 C01D.profile.u50 alpha(1,3)-fucosyltransferase activity GO:0046920 Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha(1,3)-linkage. 13 0.0321352647451426 0 0 1 C01D.profile.u50 hydrogen ion transporting ATP synthase activity, rotational mechanism GO:0046933 Catalysis of the reaction: ADP + phosphate = ATP + H2O, coupled with transport of H+ down a concentration gradient, by a rotational mechanism. 52 0.128541058980571 0 0 1 C01D.profile.u50 carboxylic acid transporter activity GO:0046943 Enables the directed movement of carboxylic acids into, out of, within or between cells. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). 103 0.254610174519207 0 0 1 C01D.profile.u50 hydrogen ion transporting ATPase activity, rotational mechanism GO:0046961 Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. 55 0.135956889306373 0 0 1 C01D.profile.u50 thyroid hormone receptor binding GO:0046966 Interacting selectively with a thyroid hormone receptor. 23 0.0568546991644831 1 17.5886956521739 0.0553351646472273 C01D.profile.u50 protein heterodimerization activity GO:0046982 Interacting selectively with a nonidentical protein to form a heterodimer. 159 0.393039007267514 2 5.0885534591195 0.0594956143371362 C01D.profile.u50 protein dimerization activity GO:0046983 The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. 447 1.10495871854452 3 2.71503355704698 0.100360137861073 C01D.profile.u50 protein N-terminus binding GO:0047485 Interacting selectively with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue. 20 0.049438868838681 0 0 1 C01D.profile.u50 3',5'-cyclic-GMP phosphodiesterase activity GO:0047555 Catalysis of the reaction: guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate. 6 0.0148316606516043 0 0 1 C01D.profile.u50 receptor antagonist activity GO:0048019 Interacts with receptors to reduce the action of another ligand, the agonist. 15 0.0370791516290107 0 0 1 C01D.profile.u50 monosaccharide binding GO:0048029 Interacting selectively with any monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. 20 0.049438868838681 0 0 1 C01D.profile.u50 cofactor binding GO:0048037 Interacting selectively with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate. 219 0.541355613783557 2 3.69442922374429 0.10281531907591 C01D.profile.u50 activin binding GO:0048185 Interacting selectively with activin. 12 0.0296633213032086 0 0 1 C01D.profile.u50 calcium-dependent protein binding GO:0048306 Interacting selectively with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium. 9 0.0222474909774064 0 0 1 C01D.profile.u50 beta-tubulin binding GO:0048487 Interacting selectively with the microtubule constituent protein beta-tubulin. 8 0.0197755475354724 0 0 1 C01D.profile.u50 GPI anchor binding GO:0048503 Interacting selectively with any glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes. 146 0.360903742522371 0 0 1 C01D.profile.u50 beta-1,3-galactosyltransferase activity GO:0048531 Catalysis of the transfer of a galactose residue from a donor molecule to an oligosaccharide, forming a beta-1,3-linkage. 9 0.0222474909774064 0 0 1 C01D.profile.u50 NADH dehydrogenase (quinone) activity GO:0050136 Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol. 39 0.0964057942354279 0 0 1 C01D.profile.u50 unspecific monooxygenase activity GO:0050381 Catalysis of the reaction: RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O. 44 0.108765511445098 0 0 1 C01D.profile.u50 FAD binding GO:0050660 Interacting selectively with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. 81 0.200227418796658 1 4.99432098765432 0.181658299484868 C01D.profile.u50 NADP binding GO:0050661 Interacting selectively with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP, or the reduced form, NADPH. 29 0.0716863598160874 0 0 1 C01D.profile.u50 coenzyme binding GO:0050662 Interacting selectively with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed. 191 0.472141197409403 2 4.23602094240838 0.0816836428768688 C01D.profile.u50 androgen receptor binding GO:0050681 Interacting selectively with an androgen receptor. 42 0.10382162456123 0 0 1 C01D.profile.u50 low-density lipoprotein receptor binding GO:0050750 Interacting selectively with a low density lipoprotein receptor. 16 0.0395510950709448 0 0 1 C01D.profile.u50 GABA receptor binding GO:0050811 Interacting selectively with the gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor. 10 0.0247194344193405 0 0 1 C01D.profile.u50 cell adhesion molecule binding GO:0050839 Interacting selectively with a cell adhesion molecule. 14 0.0346072081870767 0 0 1 C01D.profile.u50 cobalt ion binding GO:0050897 Interacting selectively with a cobalt (Co) ion. 15 0.0370791516290107 0 0 1 C01D.profile.u50 actin filament binding GO:0051015 Interacting selectively with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. 63 0.155732436841845 0 0 1 C01D.profile.u50 protein kinase A binding GO:0051018 Interacting selectively with protein kinase A. 14 0.0346072081870767 0 0 1 C01D.profile.u50 GTPase binding GO:0051020 Interacting selectively with a GTPase, any enzyme that catalyzes the hydrolysis of GTP. 113 0.279329608938548 0 0 1 C01D.profile.u50 NF-kappaB binding GO:0051059 Interacting selectively with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters. 13 0.0321352647451426 0 0 1 C01D.profile.u50 unfolded protein binding GO:0051082 Interacting selectively with an unfolded protein. 148 0.365847629406239 1 2.73337837837838 0.306705602016152 C01D.profile.u50 chaperone binding GO:0051087 Interacting selectively with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. 17 0.0420230385128788 0 0 1 C01D.profile.u50 sugar transporter activity GO:0051119 Enables the directed movement of a sugar into, out of, within or between cells. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides. 46 0.113709398328966 0 0 1 C01D.profile.u50 vitamin transporter activity GO:0051183 Enables the directed movement of vitamins into, out of, within or between cells. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. 12 0.0296633213032086 0 0 1 C01D.profile.u50 cofactor transporter activity GO:0051184 Enables the directed movement of a cofactor into, out of, within or between cells. A cofactor is a substance that is required for the activity of an enzyme or other protein. 18 0.0444949819548129 0 0 1 C01D.profile.u50 dioxygenase activity GO:0051213 Catalysis of the incorporation of both atoms of oxygen from one molecule of O2 into the (reduced) substrate. 63 0.155732436841845 0 0 1 C01D.profile.u50 phosphoprotein binding GO:0051219 Interacting selectively with a phosphorylated protein. 15 0.0370791516290107 0 0 1 C01D.profile.u50 NAD binding GO:0051287 Interacting selectively with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD, or the reduced form, NADH. 47 0.1161813417709 0 0 1 C01D.profile.u50 hormone receptor binding GO:0051427 Interacting selectively with a receptor for hormones. 71 0.175507984377317 1 5.69774647887324 0.161151587657948 C01D.profile.u50 iron-sulfur cluster binding GO:0051536 Interacting selectively with an iron-sulfur cluster, a combination of iron and sulfur atoms. 41 0.101349681119296 0 0 1 C01D.profile.u50 2 iron, 2 sulfur cluster binding GO:0051537 Interacting selectively with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. 13 0.0321352647451426 0 0 1 C01D.profile.u50 4 iron, 4 sulfur cluster binding GO:0051539 Interacting selectively with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. 21 0.051910812280615 0 0 1 C01D.profile.u50 metal cluster binding GO:0051540 Interacting selectively with a cluster of atoms including both metal ions and nonmetal atoms, usually sulfur and oxygen. Examples include iron-sulfur clusters and nickel-iron-sulfur clusters. 41 0.101349681119296 0 0 1 C01D.profile.u50 inositol trisphosphate kinase activity GO:0051766 Catalysis of the reaction: inositol trisphosphate + ATP = inositol tetrakisphosphate + ADP. 5 0.0123597172096702 0 0 1 C01D.profile.u50 peroxiredoxin activity GO:0051920 Catalysis of the reaction: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. 10 0.0247194344193405 0 0 1 C01D.profile.u50 molecular transducer activity GO:0060089 The molecular function that accepts an input of one form and creates an output of a different form. 2506 6.19469026548673 6 0.968571428571428 0.58529320483864 C01D.profile.u50 molecular adaptor activity GO:0060090 The binding activity of a molecule that brings together two or more molecules, permitting those molecules to function in a coordinated way. 101 0.249666287635339 0 0 1 C01D.profile.u50