L2L L2L Microarray Analysis Tool

Results for A01A.profile.u50

Results summary View all lists in L2L MDB View all genes in A01A.profile.u50
List Name Description Total
probes
Expected
matches
Actual
matches
Fold
Enrichment
Binomial
p-value
alk5_hmvec_2hr_up Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 347 0.86 9 10.49 2.95e-07
alk5_hmvec_4hr_up Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK5,, which activates the Smad2/3 pathway, in human microvessel endothelial cells (HMVEC). 347 0.86 9 10.49 2.95e-07
uvc_high_all_up Up-regulated at any timepoint following treatment of WS1 human skin fibroblasts with UVC at a high dose (50 J/m^2) (clusters b1-b4) 34 0.08 4 47.59 1.63e-06
alk1_hmvec_2hr_up Up-regulated 2 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 593 1.47 10 6.82 3.17e-06
alk1_hmvec_4hr_up Up-regulated 4 hr following constitutive activation of TGFbeta receptor ALK1, which activates the Smad1/5 pathway, in human microvessel endothelial cells (HMVEC). 593 1.47 10 6.82 3.17e-06
aged_mouse_neocortex_up Upregulated in the neocortex of aged adult mice (30-month) vs. young adult (5-month) 111 0.27 5 18.22 9.51e-06
hdaci_colon_tsabut_up Upregulated by both butyrate and TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 79 0.20 4 20.48 4.84e-05
insulin_adip_sens_dn Down-regulated by insulin in murine adipocytes, but response is blunted following induction of insulin-resistance with TNFalpha treatment 29 0.07 3 41.85 5.26e-05
irs1_ko_adip_up Up-regulated in brown preadipocytes from Irs1-knockout mice, which display severe defects in adipocyte differentiation, versus wild-type controls 159 0.39 5 12.72 5.35e-05
lvad_heartfailure_up Upregulated in the left ventricle myocardium of patients with heart failure following implantation of a left ventricular assist device 180 0.44 5 11.24 9.60e-05
nab_lung_up Up-regulated in human non-small cell lung carcinoma cell line H460 following 24-hour treatment with sodium butyrate 38 0.09 3 31.94 1.19e-04
tgfb_hmvec_4hr_dn Down-regulated 4 hr following treatment of human microvessel endothelial cells (HMVEC) with TGFbeta. 1321 3.27 12 3.67 1.51e-04
serum_fibroblast_core_dn Core group of genes consistently down-regulated following exposure to serum in a variety of human fibroblast cell lines (higher expression in quiescent cells, not cell-cycle dependent) 319 0.79 6 7.61 1.65e-04
p53_brca1_up Upregulated by expression of p53 in p53-null, brca1-null MEFs; most genes are further upregulated by simultaneous expression of BRCA1 49 0.12 3 24.77 2.56e-04
hdaci_colon_tsa_up Upregulated by TSA at any timepoint up to 48 hrs in SW260 colon carcinoma cells 122 0.30 4 13.26 2.60e-04
hdaci_colon_cluster1 Regulated by TSA, butyrate and/or curcumin in SW260 colon carcinoma cells (Cluster 1) 12 0.03 2 67.42 3.97e-04
hdaci_colon_tsa2hrs_up Upregulated by TSA at 2 hrs in SW260 colon carcinoma cells 61 0.15 3 19.90 4.88e-04
et743_blockstsa Normally induced by the HDACi TSA, but induction is blocked by Et-743 15 0.04 2 53.94 6.28e-04
fsh_rat_granulosa_up Up-regulated by FSH in immortalized rat granulosa cells (rFSH-17) 15 0.04 2 53.94 6.28e-04
et743_sarcoma_24hrs_up Up-regulated at 24 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines 16 0.04 2 50.57 7.17e-04
hypoxia_review Genes known to be induced by hypoxia 160 0.40 4 10.11 7.22e-04
heat_glioblastoma_up Up-regulated following 1 hr 43degC heat shock in human glioblastoma cells (U87MG). 78 0.19 3 15.56 1.00e-03
heatshock_hela_2hr_up Up-regulated at 2 hours following 1.5 hr 43degC heat shock of HeLa cells compared to untreated controls (> 1.5-fold, FDR < 0.05). 177 0.44 4 9.14 1.05e-03
hdaci_colon_tsa12hrs_up Upregulated by TSA at 12 hrs in SW260 colon carcinoma cells 21 0.05 2 38.53 1.24e-03
hdaci_colon_but2hrs_up Upregulated by butyrate at 2 hrs in SW260 colon carcinoma cells 87 0.22 3 13.95 1.37e-03
emt_dn Down-regulated during the TGFbeta-induced epithelial-to-mesenchymal transition (EMT) of Ras-transformed mouse mammary epithelial (EpH4) cells (EMT is representative of late-stage tumor progression and metastasis) 89 0.22 3 13.64 1.46e-03
dex_keratinocyte_1hr_dn Down-regulated in primary human keratinocytes at 1 hour following treatment with 0.1 microM dexamethasone 24 0.06 2 33.71 1.63e-03
hdaci_colon_but24hrs_up Upregulated by butyrate at 24 hrs in SW260 colon carcinoma cells 95 0.23 3 12.77 1.76e-03
preadip_vs_fibro_up Upregulated following 6hr differentiation of murine 3T3-L1 fibroblasts into preadipocytes; presumed direct transcriptional targets of differentiation cocktail of insulin, dexamethasone and isobutyl-methylxanthine 29 0.07 2 27.90 2.37e-03
pubertal_mammary_4-5wks_up Up-regulated > 1.5-fold in the developing mouse mammary gland between 4 and 5 weeks of age. 368 0.91 5 5.50 2.41e-03
hypoxia_normal_up Upregulated by hypoxia in normal, RPTEC renal cells (Fig. 3) 376 0.93 5 5.38 2.64e-03
stemcell_hematopoietic_up Enriched in mouse hematopoietic stem cells, compared to differentiated brain and bone marrow cells 2092 5.17 13 2.51 2.65e-03
fsh_human_granulosa_up Up-regulated by FSH in primary human granulosa cells (rFSH-17) 31 0.08 2 26.10 2.71e-03
hdaci_colon_but_up Upregulated by butyrate at any timepoint up to 48 hrs in SW260 colon carcinoma cells 233 0.58 4 6.94 2.85e-03
tgfb_mammary_up Up-regulated in normal mouse mammary gland cells following treatment with TGF-beta (top 124 genes). 118 0.29 3 10.28 3.26e-03
rb_creko_dn Down-regulated at 144 hours after disruption of Rb in adult mouse fibroblasts by Cre recombination, versus GFP controls. 250 0.62 4 6.47 3.66e-03
ros_mouse_aorta_dn Down-regulated in mouse aorta by chronic treatment with PPARgamma agonist rosiglitazone 127 0.31 3 9.56 4.01e-03
vegf_hmmec_12hrs_up Up-regulated at 12hrs follwing VEGF treatment of human myometrial microvascular endothelial cells 38 0.09 2 21.29 4.05e-03
elongina_ko_up Upregulated in MES cells from elongin-A knockout mice 263 0.65 4 6.15 4.38e-03
stress_arsenic_specific_up Genes up-regulated 4 hours following arsenic treatment that discriminate arsenic from other stress agents 266 0.66 4 6.08 4.56e-03
pubertal_mammary Differentially expressed (> 2-fold) in the developing mouse mammary gland at any time point between 3- and 7-weeks of age. 1260 3.11 9 2.89 4.77e-03
idx_tsa_up_cluster1 Strongly up-regulated at 2 hours during differentiation of 3T3-L1 fibroblasts into adipocytes with IDX (insulin, dexamethasone and isobutylxanthine), vs. fibroblasts treated with IDX + TSA to prevent differentiation (cluster 1) 44 0.11 2 18.39 5.40e-03
ageing_brain_up Age-upregulated in the human frontal cortex 446 1.10 5 4.54 5.41e-03
oxstress_breastca_up Upregulated by H2O2, Menadione and t-BH in breast cancer cells 45 0.11 2 17.98 5.64e-03
hdaci_colon_but16hrs_up Upregulated by butyrate at 16 hrs in SW260 colon carcinoma cells 47 0.12 2 17.21 6.14e-03
hdaci_colon_but12hrs_up Upregulated by butyrate at 12 hrs in SW260 colon carcinoma cells 54 0.13 2 14.98 8.03e-03
oldonly_fibro_up Upregulated in fibroblasts from old (but not Werner) individuals, compared to young 54 0.13 2 14.98 8.03e-03
hdaci_colon_but48hrs_dn Downregulated by butyrate at 48 hrs in SW260 colon carcinoma cells 165 0.41 3 7.36 8.25e-03
et743_sarcoma_6hrs_up Up-regulated at 6 hours following treatment with Et-743 in at least 8 of 11 sarcoma cell lines 56 0.14 2 14.45 8.61e-03
zmpste24_ko_up Fifty genes most strongly up-regulated in liver tissue from mice deficient in the lamin-protease Zmpste24/Face1, versus wild-type controls 57 0.14 2 14.19 8.91e-03

Raw data (tab-delimited .txt)